Guidelines of care for the management of cutaneous squamous cell carcinoma

Alam, Murad; Armstrong, April W.; Baum, Christian L.; Bordeaux, Jeremy S.; Brown, Marc D.; Busam, Klaus J.; Eisen, Daniel B.; Iyengar, Vivek; Lober, Clifford W.; Margolis, David J.; Messina, Jane L.; Miller, Alexander; Miller, Stanley J.; Mostow, Eliot N.; Mowad, Christen; Nehal, Kishwer S.; Schmitt-Burr, Kristi; Sekulić, Aleksandar; Storrs, Paul A.; Teng, Joyce; Yu, Siegrid S.; Huang, Conway C.; Boyer, Kevin; Begolka, Wendy Smith; Bichakjian, Christopher K.; Kim, John Y.S.; Kozlow, Jeffrey H.; Mittal, Bharat B.; Moyer, Jeffrey S.; Olenecki, Thomas; Rodgers, Philip T.

doi:10.1016/j.jaad.2017.10.007

Cited by 366 publications

(306 citation statements)

References 127 publications

(134 reference statements)

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“…A parallel American Academy of Dermatology (AAD) guideline on cSCC has also been developed. 1 MeSH (Medical Subject Headings) terms used in various combinations in the literature search included carcinoma, basal cell carcinoma, squamous cell A total of 1120 articles were systematically reviewed for possible inclusion; 188 were retained on the basis of relevancy and the highest level of available evidence for the outlined clinical questions. Evidence tables were generated for these 188 studies and utilized by the work group in developing recommendations.…”

Section: Methodsmentioning

confidence: 99%

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

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326

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Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed. ( J Am Acad Dermatol

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Section: Methodsmentioning

confidence: 99%

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

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326

219

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“…Both BCC and cSCC can be successfully treated by a variety of modalities and guidelines for their management have been recently published (13,(115)(116)(117). Treatment selection is often guided by patient features, such as comorbidities and preferences, tumor features, that stratify keratinocyte carcinomas into low-risk and high-risk tumors ( Table 1; Fig.…”

Section: Treatmentmentioning

confidence: 99%

Keratinocyte Carcinomas: Current Concepts and Future Research Priorities

Nagarajan

Asgari

Green

et al. 2019

Clinical Cancer Research

105

123

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Cutaneous squamous cell carcinoma (cSCC) and basal cell carcinoma (BCC) are keratinocyte carcinomas, the most frequently diagnosed cancers in fair-skinned populations. Ultraviolet radiation (UVR) is the main driving carcinogen for these tumors, but immunosuppression, pigmentary factors, and aging are also risk factors. Scientific discoveries have improved the understanding of the role of human papillomaviruses (HPV) in cSCC as well as the skin microbiome and a compromised immune system in the development of both cSCC and BCC. Genomic analyses have uncovered genetic risk variants, high-risk susceptibility genes, and somatic events that underlie common pathways important in keratinocyte carcinoma tumorigenesis and tumor characteristics that have enabled development of prediction models for early identification of high-risk individuals. Advances in chemoprevention in high-risk individuals and progress in targeted and immune-based treatment approaches have the potential to decrease the morbidity and mortality associated with these tumors. As the incidence and prevalence of keratinocyte carcinoma continue to increase, strategies for prevention, including effective sun-protective behavior, educational interventions, and reduction of tanning bed access and usage, are essential. Gaps in our knowledge requiring additional research to reduce the high morbidity and costs associated with keratinocyte carcinoma include better understanding of factors leading to more aggressive tumors, the roles of microbiome and HPV infection, prediction of response to therapies including immune checkpoint blockade, and how to tailor both prevention and treatment to individual risk factors and needs.

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“…Treatment of regional nodal metastases typically includes lymph node dissection combined with radiotherapy [9], as performed in the presented case. The role of sentinel node biopsy in cutaneous SCC is to date unclear and is not routinely performed [12]. As shown in this case, fine-needle biopsy is not always reliant in revealing SCC metastasis, and excision of complete lymph nodes is, as a consequence, often necessary.…”

Section: Discussionmentioning

confidence: 97%

Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report

Wernheden

Trøstrup²,

Pilt³

2020

Case Rep Dermatol

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Cutaneous spindle cell squamous cell carcinoma (SpSCC) is a rare and often aggressive subtype of squamous cell carcinoma (SCC), which usually appears in sun-exposed areas, in areas that have received prior ionizing radiation, or in immunosuppressed individuals. SpSCCs are histologically characterized by keratinocytes infiltrating the dermis as single cells with elongated nuclei rather than as cohesive nests or islands and, in contrast to conventional SCC, are lacking features of keratinization. Immunohistochemical studies are useful to distinguish SpSCC from other spindle cell neoplasms, such as spindle cell/desmoplastic melanoma, cutaneous leiomyosarcoma, and atypical fibroxanthoma. We present a rare case of a patient with SpSCC in the gluteal region with regional lymph node metastasis. The patient was treated with wide excision of the tumor, inguinal lymph node dissection, and adjuvant radiotherapy. Cutaneous SpSCC is clinically similar to conventional SCC but can demonstrate more aggressive behavior. This case is rare since it was localized in the gluteal region of an otherwise healthy man.

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Guidelines of care for the management of cutaneous squamous cell carcinoma

Cited by 366 publications

References 127 publications

Guidelines of care for the management of basal cell carcinoma

Guidelines of care for the management of basal cell carcinoma

Keratinocyte Carcinomas: Current Concepts and Future Research Priorities

Unusual Presentation of Cutaneous Spindle Cell Squamous Cell Carcinoma: A Case Report

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