Guidelines on the diagnosis and treatment for acute promyelocytic leukemia: Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular Guidelines Project: Associação Médica Brasileira - 2013

Pagnano, Kátia Bórgia Barbosa; Rego, Eduardo Magalhães; Rohr, S.; Chauffaille, Maria de Lourdes Lopes Ferrari; Jácomo, Rafael H.; Bittencourt, Rosane; Firmato, Ana Beatriz; Fagundes, Evandro M.; Melo, Raul Antonio Moraes; Bernardo, Wanderley Marques

doi:10.5581/1516-8484.20140018

Cited by 20 publications

(17 citation statements)

References 91 publications

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“…Arsenic trioxide acts by binding to the PML fusion protein and results in its degradation, thus Common side effects include prolongation of the QT interval, arrhythmias, rash, and hepatotoxicity. 11 Coagulopathy requires urgent treatment with commencement of all-trans retinoic acid and blood product support. Blood product replacement is based on coagulation laboratory tests.…”

Section: Discussionmentioning

confidence: 99%

Bruising and abnormal leucocytes on a blood film—a haematological emergency

Chavda

Lindsay

Willis

et al. 2017

BMJ

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Section: Discussionmentioning

confidence: 99%

Bruising and abnormal leucocytes on a blood film—a haematological emergency

Chavda

Lindsay

Willis

et al. 2017

BMJ

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“…In our study all national coordinating centres were university hospitals or centres specialized in diagnosis and treatment of haematological diseases (tertiary care centres). However, patients were frequently initially admitted to emergency rooms, and thus the aforementioned measures had already been started at the secondary care level (before admission to the haematology ward or specialized centre) (Pagnano et al , ). Moreover, BM aspirates were evaluated for the presence of the PML/RARA rearrangement using the anti‐PML immunofluorescence test and reverse‐transcription polymerase chain reaction (RT‐PCR), which were performed in the National Reference Laboratory (the anti‐PML immunofluorescence test was also performed locally and could be performed in secondary care centres).…”

Section: Ic‐apl Initiativementioning

confidence: 99%

Treating acute promyelocytic leukaemia in Latin America: lessons from the International Consortium on Acute Leukaemia experience

et al. 2017

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SummaryThe Latin Americas and Caribbean are regions where social exclusion and inequality persist as the main obstacles to human development and improvement of health conditions, despite economic growth and social development. These countries need to establish international collaborations with the goal of improving health conditions. In this scenario Acute Promyelocytic Leukaemia (APL), a disease with a high cure rate in developed countries and high prevalence in young patients, offers an ideal opportunity to implement measures with educational and cooperative scope. We discuss the experience of Latin America and the Caribbean through a common network, the International Consortium on Acute Promyelocytic Leukaemia (IC-APL).

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“…In 98% of APL patients, a balanced translocation between chromosomes 15 and 17 [t(15;17) (q22;q21)] was found, which leads to the formation and fusion of promelocytic leukemia protein (PML) and retinoic acid receptor alpha (RARα) [30,31]. A variety of chromosomal aberrations have been identified in APL including t(11;17)(q23;q21), t(5;17)(q35;q12-21), t(11;17)(q13;q21), and der (17), in which the RARα gene is fused to the PLZF, NPM, NuMA, and STAT5b genes, respectively [32]. The differentiation of leukemic cells and complete remission of APL may occur after treatment with ATRA (all-trans retinoic acid).…”

Section: Myeloid Leukemiamentioning

confidence: 99%