Guillain-Barré syndrome

Hughes, Richard; Cornblath, David R.

doi:10.1016/s0140-6736(05)67665-9

Cited by 1,450 publications

(1,305 citation statements)

References 158 publications

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“…1c, d) showed enhancement in the medullary cone, in the roots of cauda equina in dorsal, and in ventral nerve roots; T2 images revealed increased signal intensity in the spinal ganglia bilaterally at all levels of the lumbar spine with intense contrast enhancement. These features have been described in prior cases of GBS [5] and attributed to demyelination, ischemia, inflammation, and breakdown of the bloodnerve barrier, as occurs in autoimmune polyneuropathy [4,5]. In conclusion, imaging studies can assist in the differential diagnosis of complications in patients with Zika.…”

mentioning

confidence: 66%

“…We would like to present the magnetic resonance imaging (MRI) neural axis findings in a 51-year-old female patient who developed neurological symptoms compatible with acute demyelinating polyneuropathy, characteristic of GBS [4]. She presented in our emergency department with symptoms suggestive of Zika including difficulty walking, non-purulent conjunctivitis, rash, myalgia, and arthralgia for 12 days.…”

mentioning

confidence: 99%

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Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection

2016

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confidence: 66%

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confidence: 99%

Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection

2016

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“…The man developed acute urinary retention, weakness, limbs numbness, and difficulty in walking within 10 days after the vaccine inoculation. Positive anti-GM2 antibodies, which are frequently found in GBS associated with cytomegalovirus infection [43] were detected. Furthermore, Terryberry et al [44] examined the cerebrospinal fluid (CSF) protein level (normal range 125-150 mg/L) that is always elevated (>400 mg/L) in GBS patients for the presence of antibodies against 18 myelin autoantigens.…”

Section: Influenza Vaccine and Guillain-barre Syndromementioning

confidence: 98%

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

et al. 2017

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Autoimmune diseases, including multiple sclerosis and type 1 diabetes mellitus, affect about 5% of the worldwide population. In the last decade, reports have accumulated on various autoimmune disorders, such as idiopathic thrombocytopenia purpura, myopericarditis, primary ovarian failure, and systemic lupus erythematosus (SLE), following vaccination. In this review, we discuss the possible underlying mechanisms of autoimmune reactions following vaccinations and review cases of autoimmune diseases that have been correlated with vaccination. Molecular mimicry and bystander activation are reported as possible mechanisms by which vaccines can cause autoimmune reactions. The individuals who might be susceptible to develop these reactions could be especially not only those with previous post-vaccination phenomena and those with allergies but also in individuals who are prone to develop autoimmune diseases, such as those with a family history of autoimmunity or with known autoantibodies, and the genetic predisposed individuals.Further research is encouraged into the direct associations between vaccines and autoimmune conditions, and the biological mechanisms behind them.

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“…The incidence of AIDP/GBS is roughly 12 to 19 per million of the population per year, and males are more commonly affected than females [87]. The diagnosis of AIDP/GBS depends on the appropriate clinical presentation with ascending weakness and the finding of areflexia.…”

Section: Guillain-barré Syndromementioning

confidence: 99%

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

Geldern¹,

McPharlin

Becker

2012

Neurotherapeutics

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This chapter will review the spectrum of immunemediated diseases that affect the nervous system and may result in an admission to the neurological intensive care unit. Immunomodulatory strategies to treat acute exacerbations of neurological diseases caused by aberrant immune responses are discussed, but strategies for long-term immunosuppression are not presented. The recommendations for therapeutic intervention are based on a synthesis of the literature, and include recommendations by the Cochrane Collaborative, the American Academy of Neurology, and other key organizations. References from recent publications are provided for the disorders and therapies in which randomized clinical trials and large evidenced-based reviews do not exist. The chapter concludes with a brief review of the mechanisms of action, dosing, and side effects of commonly used immunosuppressive strategies in the neurocritical care unit.

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Guillain-Barré syndrome

Cited by 1,450 publications

References 158 publications

Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection

Magnetic resonance imaging findings in Guillain-Barré syndrome caused by Zika virus infection

Vaccination and autoimmune diseases: is prevention of adverse health effects on the horizon?

Immune Mediated Diseases and Immune Modulation in the Neurocritical Care Unit

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