Gum tragacanth stabilized green gold nanoparticles as cargos for Naringin loading: A morphological investigation through AFM

Rao, Komal; Imran, Muhammad; Jabri, Tooba; Ali, İrshad; Perveen, Shahida; Shafiullah,; Ahmed, Shakil; Shah, Muhammad Raza

doi:10.1016/j.carbpol.2017.06.071

Cited by 76 publications

(33 citation statements)

References 36 publications

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“…It uses inexpensive and safe methods for synthesis of metal NPs, thus eliminating the use of toxic materials. Using inactivated plants gums, tissues or other parts as reducing/stabilizing agents for metal NPs has been best alternative to synthetic toxic reducing molecules [13]. GA is a water-soluble polysaccharide produced by Acacia Seyal and Senegal.…”

Section: Introductionmentioning

confidence: 99%

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Rao

Aziz

Roome

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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Nanomedicines anticipate drug delivery to inflamed tissues in rheumatoid arthritis (RA) with greater efficacy and lesser side effects. This study investigates the anti-arthritic potentials of Hesperidin (HP) loaded in gum acacia (GA) stabilized green silver nanoparticles (AgNPs). Synthesized GA-AgNPs were characterized through UV-vis spectrophotometer, zetasizer and atomic force microscope (AFM). The HP and its loaded NPs were tested for RA in Complete Freund's adjuvant (CFA) induced arthritis model. GA-AgNPs were found in nano-range size with negative charge, spherical shape and loaded increased HP amount. HP loaded GA-AgNPs showed minimal arthritic score exhibiting mild to moderate tissue swelling, reduced degenerative changes along with mild articular changes. Histopathological analysis revealed comparatively lesser influx of inflammatory cells and diminished granulamatous inflammation in ankle joints tissues in the presence of HP loaded GA-AgNPs. RT-PCR revealed that HP loaded GA-AgNPs significantly reduced the TLRs mRNA expression. Results validate GA stabilized green AgNPs as stable nano-cargos for targeted delivery of HP for restoring the progression of RA.

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Section: Introductionmentioning

confidence: 99%

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Rao

Aziz

Roome

et al. 2018

Artificial Cells, Nanomedicine, and Biotechnology

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“…For instance, in comparison with Dex, Naringin is capable of repressing adipogenesis while solely promoting the osteogenic commitment of human bone marrow–derived mesenchymal stem cells (hBM‐MSCs) . Also, Dex systemic administration is characterized by a plethora of deleterious side effects, while Naringin is recognized to possess a wide range of antioxidant, anti‐inflammatory, anticancer, and antimicrobial activities . Recent studies also highlight Naringin's ability to enhance the secretion of BMP‐2 in osteoprogenitor cells (e.g., murine fetal primary osteoblasts) and can exert a synergistic osteogenic effect with this osteoinductive protein .…”

Section: Introductionmentioning

confidence: 99%

Bioinstructive Naringin‐Loaded Micelles for Guiding Stem Cell Osteodifferentiation

Lavrador

Gaspar

Mano

2018

Adv Healthcare Materials

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Naringin is a naturally occurring flavanone with recognized neuroprotective, cardioprotective, anti-inflammatory, and antiosteoporotic properties. Herein, the delivery of Naringin-loaded methoxy-poly(ethylene glycol)-maleimide-thiol-poly(l-lactide) (mPEGMSPLA) diblock polymeric micelles to human adipose-derived stem cells (hASCs) with the aim to augment its pro-osteogenic effect in these cells is reported for the first time. The synthesis of the diblock copolymer is performed via Michael-type addition reaction between hydrophilic methoxy-poly(ethylene glycol)-maleimide (mPEGMAL) and hydrophobic thiol-poly(l-lactide) (PLASH) and confirmed by H NMR and attenuated total reflectance Fourier transformed infrared (ATR-FTIR) spectroscopy. The resulting mPEGMSPLA copolymer self-assembles into monodispersed polymeric micelles (≈84.4 ± 2 nm) and presents a high Naringin encapsulation efficiency (87.8 ± 4%), with a sustained release profile at physiological pH. Alongside, in vitro data reveal that upon internalization into hASC 2D cultures, Naringin nanomicellar formulations attain a higher pro-osteogenic effect than that of free drug. Notably, these bioactive carriers also induce superior osteopontin expression and increase matrix mineralization in these cells over free drug administration. Overall, such findings support for the first time the use of polymeric nanomicelles for Naringin delivery into hASCs as a valid approach for modulating stem cell osteogenic differentiation.

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“…The use of nature-derived biopolymers such as chitosan has received attention for the fabrication and stabilization of metal nanoparticles owing to biological and environmental safety and costeffectiveness [37]. Metal nanoparticles that have been reduced/stabilized with biopolymers demonstrate higher stability against pH and electrolytes changes in comparison to their counterparts stabilized with synthetic or other small molecules [38]. In the current study, chitosan was employed as the reducing as well as a stabilizing agent for the synthesis of AgNPs.…”

Section: Synthesis Of Chi-agnpsmentioning

confidence: 99%

Chitosan Stabilized Silver Nanoparticles for the Electrochemical Detection of Lipopolysaccharide: A Facile Biosensing Approach for Gram-Negative Bacteria

et al. 2020

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Negatively charged lipopolysaccharide (LPS), a major endotoxin and component of the outer membrane of several Gram-negative bacteria, provides a useful biomarker for the indirect detection of these pathogens. For instance, Escherichia coli (E. coli) is a pathogenic bacterium that causes infections in almost all age groups, and has been implicated in food and water contamination. Current diagnostic and detection methods tend to be labor-intensive or expensive, necessitating the need for an easy, sensitive, rapid, and low-cost method. We report on the synthesis and use of positively charged chitosan stabilized silver nanoparticles (Chi-AgNPs) as a sensitive electrochemical nanobiosensor for the detection of LPS. Chi-AgNPs were synthesized through a facile, single step protocol, and characterized for size, charge, and morphology. Glassy carbon electrodes modified with Chi-AgNPs resulted in an enhancement of signal in the presence of both LPS and E. coli. Detection was accomplished over a large concentration range (several orders of magnitude) of 0.001–100 ng/mL and 10–107 CFU/mL. The biosensors can reliably detect LPS and E. coli at very low concentrations. Chi-AgNPs have potential as low cost, sensitive nanobiosensors for Gram-negative bacteria due to strong electrostatic interaction with LPS present in their outer membranes.

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Gum tragacanth stabilized green gold nanoparticles as cargos for Naringin loading: A morphological investigation through AFM

Cited by 76 publications

References 36 publications

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Gum acacia stabilized silver nanoparticles based nano-cargo for enhanced anti-arthritic potentials of hesperidin in adjuvant induced arthritic rats

Bioinstructive Naringin‐Loaded Micelles for Guiding Stem Cell Osteodifferentiation

Chitosan Stabilized Silver Nanoparticles for the Electrochemical Detection of Lipopolysaccharide: A Facile Biosensing Approach for Gram-Negative Bacteria

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