Gut microbiome interactions with graphene based nanomaterials: Challenges and opportunities

Bantun, Farkad; Singh, R. P.; Alkhanani, Mustfa; Almalki, Atiah H.; Alshammary, Freah; Khan, Saif; Haque, Shafiul; Srivastava, Manish

doi:10.1016/j.scitotenv.2022.154789

Cited by 16 publications

(10 citation statements)

References 95 publications

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“…Thus, growth inhibition is associated with GO accumulation within the intestine, which may cause several toxicological mechanisms contributing to the observed effects. GO is known to exert antimicrobial activities [ 70 ], which are able to impair the gut microbiome of organisms [ 71 ]. In chironomids, the gut microbiota is known to protect the host from contaminants, while its impairment was associated with larval growth impairment in organisms exposed to contaminants [ 72 , 73 , 74 ].…”

Section: Resultsmentioning

confidence: 99%

Exposure of Midge Larvae (Chironomus riparius) to Graphene Oxide Leads to Development Alterations

Evariste

Lagier

Chary

et al. 2022

Toxics

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Despite the fast-growing use and production of graphene-based nanomaterials (GBMs), data concerning their effects on freshwater benthic macroinvertebrates are scarce. This study aims to investigate the effects of graphene oxide (GO) on the midge Chironomus riparius. Mortality, growth inhibition, development delay and teratogenicity, assessed using mentum deformity analysis, were investigated after a 7-day static exposure of the first instar larvae under controlled conditions. The collected data indicated that the survival rate was not impacted by GO, whereas chronic toxicity following a dose-dependent response occurred. Larval growth was affected, leading to a significant reduction in larval length (from 4.4 to 10.1%) in individuals reaching the fourth instar at any of the tested concentrations (from 0.1 to 100 mg/L). However, exposure to GO is not associated with an increased occurrence of mouthpart deformities or seriousness in larvae. These results highlight the suitability of monitoring the larval development of C. riparius as a sensitive marker of GO toxicity. The potential ecological consequences of larval size decrease need to be considered for a complete characterization of the GO-related environmental risk.

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Section: Resultsmentioning

confidence: 99%

Exposure of Midge Larvae (Chironomus riparius) to Graphene Oxide Leads to Development Alterations

Evariste

Lagier

Chary

et al. 2022

Toxics

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“…Therefore, there is a possibility that intentional or unintentional exposure of graphene nanoparticles might inuence the host health. 17,18 In vitro model studies…”

Section: The Influence Of Graphene-based Nanomaterials On the Gut Mic...mentioning

confidence: 99%

“…143,144 This could potentially lead to cell cytotoxicity and a shi in the gut microbiota composition. 17 Research suggests that oxidative stress biomarkers could be elevated aer exposure to graphene and its derivatives. This includes levels of oxidative stress, lipid peroxidation, superoxide dismutase, catalase, reactive oxygen species and 8hydroxydeoxyguanosine.…”

Section: Possible Mechanism Of Graphenebased Nanomaterials' Influence...mentioning

confidence: 99%

“…15 Several in vivo and in vitro studies examined the impact of the exposure to graphenebased nanomaterials and their potential health risk (reviewed in ref. [16][17][18][19]. Due to the oral exposure of the graphene-based nanoparticles, which also results from inhaled nanomaterials being absorbed aer mucous membrane clearance, not only is the host gastrointestinal tract (GI) exposed to potential nanotoxicity, but the alteration in the microbial composition in the gut is also considered.…”

Section: Introductionmentioning

confidence: 99%

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The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

Wojciechowska,

Costabile,

Kujawska

2023

Nanoscale Adv.

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“…It is also necessary to consider capacity of CNMs to affect the composition and function of the microbiome (have an antimicrobial effect against certain types of bacteria and affect microbial diversity), which further influences the activity of the immune system and can be used, for example, in the treatment of inflammatory bowel diseases [ 163 , 164 ]. However, such modulation could also lead to disbalanced overpopulation of specific bacterial strain.…”

Section: Modulationmentioning

confidence: 99%

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

Švadláková

Holmannová

Koláčková

et al. 2022

IJMS

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In the field of science, technology and medicine, carbon-based nanomaterials and nanoparticles (CNMs) are becoming attractive nanomaterials that are increasingly used. However, it is important to acknowledge the risk of nanotoxicity that comes with the widespread use of CNMs. CNMs can enter the body via inhalation, ingestion, intravenously or by any other route, spread through the bloodstream and penetrate tissues where (in both compartments) they interact with components of the immune system. Like invading pathogens, CNMs can be recognized by large numbers of receptors that are present on the surface of innate immune cells, notably monocytes and macrophages. Depending on the physicochemical properties of CNMs, i.e., shape, size, or adsorbed contamination, phagocytes try to engulf and process CNMs, which might induce pro/anti-inflammatory response or lead to modulation and disruption of basic immune activity. This review focuses on existing data on the immunotoxic potential of CNMs, particularly in professional phagocytes, as they play a central role in processing and eliminating foreign particles. The results of immunotoxic studies are also described in the context of the entry routes, impacts of contamination and means of possible elimination. Mechanisms of proinflammatory effect depending on endocytosis and intracellular distribution of CNMs are highlighted as well.

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Gut microbiome interactions with graphene based nanomaterials: Challenges and opportunities

Cited by 16 publications

References 95 publications

Exposure of Midge Larvae (Chironomus riparius) to Graphene Oxide Leads to Development Alterations

Exposure of Midge Larvae (Chironomus riparius) to Graphene Oxide Leads to Development Alterations

The gut microbiome meets nanomaterials: exposure and interplay with graphene nanoparticles

Immunotoxicity of Carbon-Based Nanomaterials, Starring Phagocytes

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