Gut microbiota depletion affects nutritional and behavioral responses to activity-based anorexia model in a sex-dependent manner

Tirelle, P.; Bretón, J.; Kauffmann, Alexandre; Bahlouli, W.; L’Huillier, C.; Salameh, É.; Amamou, A.; Jarbeau, M.; Guérin, Charlène; Goichon, A.; Rego, Jean–Claude do; Déchelotte, Pierre; Ribet, David; Coëffier, Moı̈se

doi:10.1016/j.clnu.2021.04.014

Cited by 14 publications

(13 citation statements)

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“…In addition, these effects were reduced but not eliminated with milder antibiotic regimens where, unlike with the four-drug regimen, the mice still gained weight. Furthermore, while some previous work has used whole-mouse NMR spectroscopy to determine body composition [ 27 , 28 ], our data suggest that even when lean and fat mass is similar by this method, that this can mask considerable variability in the distribution of lean and fat mass. Taken together, our results suggest that multiple antibiotic interventions, along with evaluation of food and water consumption, should be considered to ensure robustness of findings from studies that experimentally modulate the microbiome.…”

Section: Discussionmentioning

confidence: 53%

“…It also identifies two regimens, cefoperazone and enrofloxacin/ampicillin, which have less of an aversive effect than the commonly-used four drug regimen, although even these do not eliminate the effect. Additionally, some studies have suggested that oral antibiotic gavage may have even less of an aversive effect [ 9 , 27 , 28 ], although quantitative measures of food and water consumption and tissue-specific evaluation of these treatments are limited, requiring additional study.…”

Section: Discussionmentioning

confidence: 99%

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Antibiotics cause metabolic changes in mice primarily through microbiome modulation rather than behavioral changes

et al. 2022

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Background The microbiome is an important and increasingly-studied mediator of organismal metabolism, although how the microbiome affects metabolism remains incompletely understood. Many investigators use antibiotics to experimentally perturb the microbiome. However, antibiotics have poorly understood yet profound off-target effects on behavior and diet, including food and water aversion, that can confound experiments and limit their applicability. We thus sought to determine the relative influence of microbiome modulation and off-target antibiotic effects on the behavior and metabolic activity of mice. Results Mice treated with oral antibiotics via drinking water exhibited significant weight loss in fat, liver, and muscle tissue. These mice also exhibited a reduction in water and food consumption, with marked variability across antibiotic regimens. While administration of bitter-tasting but antimicrobially-inert compounds caused a similar reduction in water consumption, this did not cause tissue weight loss or reduced food consumption. Mice administered intraperitoneal antibiotics (bypassing the gastrointestinal tract) exhibited reduced tissue weights and oral intake, comparable to the effects of oral antibiotics. Antibiotic-treated germ-free mice did not have reduced tissue weights, providing further evidence that direct microbiome modulation (rather than behavioral effects) mediates these metabolic changes. Conclusions While oral antibiotics cause profound effects on food and water consumption, antibiotic effects on organismal metabolism are primarily mediated by microbiome modulation. We demonstrate that tissue-specific weight loss following antibiotic administration is due primarily to microbiome effects rather than food and water aversion, and identify antibiotic regimens that effectively modulate gut microbiota while minimizing off-target behavioral effects.

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Antibiotics cause metabolic changes in mice primarily through microbiome modulation rather than behavioral changes

et al. 2022

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“…Several researches have reported the changes in gut microbiota caused by the ABA model. 41,42 This evidence underscores the critical function of the diverse metabolites of the gut microbiota in the regulation of host physiological health. In our metabolomic analysis, we observed a reduced abundance of PUFAs in the cecal contents of the ABA mice.…”

Section: Discussionmentioning

confidence: 92%

Streptococcus salivarius subsp. thermophilus CCFM1312 enhanced mice resilience to activity-based anorexia

Zhu,

Lan,

Qian

et al. 2024

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“…For both, patients with AN [28] and the ABA model [29,30], a gut microbiota dysbiosis has been reported. Interestingly, we recently showed that gut microbiota depletion limited body weight loss in ABA mice and altered mood disorders in a sex-dependent manner [31]. Thus, microbiotaegutebrain axis seems to contribute to the pathophysiology of AN, and an increased intestinal permeability is one piece of the puzzle.…”

Section: Discussionmentioning

confidence: 99%

Intestinal permeability and appetite regulating peptides-reactive immunoglobulins in severely malnourished women with anorexia nervosa

et al. 2022

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Gut microbiota depletion affects nutritional and behavioral responses to activity-based anorexia model in a sex-dependent manner

Cited by 14 publications

References 50 publications

Antibiotics cause metabolic changes in mice primarily through microbiome modulation rather than behavioral changes

Antibiotics cause metabolic changes in mice primarily through microbiome modulation rather than behavioral changes

Streptococcus salivarius subsp. thermophilus CCFM1312 enhanced mice resilience to activity-based anorexia

Intestinal permeability and appetite regulating peptides-reactive immunoglobulins in severely malnourished women with anorexia nervosa

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