Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity

Moreno-Navarrete, José María; Sérino, Matteo; Blasco-Baqué, Vincent; Azalbert, Vincent; Barton, Richard H.; Cardellini, Marina; Latorre, Jèssica; Ortega, Francisco; Sabater-Masdeu, Mònica; Burcelin, Rémy; Dumas, Marc; Ricart, Wifredo; Federici, Massimo; Fernández‐Real, José Manuel

doi:10.1002/mnfr.201700721

Cited by 82 publications

(79 citation statements)

References 45 publications

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“…In a study with NAFLD patients, acetate was found increased in circulatory level and fecal level, analyzed by NMR. This increase was correlated with the reduction of the abundance of several bacterial species as Ruminococcus, Coprococcus, and F. prausnitzii [58]. HFD-induced obesity and IR in rats is associated with increased plasma concentration of acetate metabolized by the gut microbiota measured with GS-MS [33].…”

Section: Acetatementioning

confidence: 83%

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

et al. 2020

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The metabolic syndrome is a multifactorial disease developed due to accumulation and chronification of several risk factors associated with disrupted metabolism. The early detection of the biomarkers by NMR spectroscopy could be helpful to prevent multifactorial diseases. The exposure of each risk factor can be detected by traditional molecular markers but the current biomarkers have not been enough precise to detect the primary stages of disease. Thus, there is a need to obtain novel molecular markers of pre-disease stages. A promising source of new molecular markers are metabolomics standing out the research of biomarkers in NMR approaches. An increasing number of nutritionists integrate metabolomics into their study design, making nutrimetabolomics one of the most promising avenues for improving personalized nutrition. This review highlight the major five risk factors associated with metabolic syndrome and related diseases including carbohydrate dysfunction, dyslipidemia, oxidative stress, inflammation, and gut microbiota dysbiosis. Together, it is proposed a profile of metabolites of each risk factor obtained from NMR approaches to target them using personalized nutrition, which will improve the quality of life for these patients.

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Section: Acetatementioning

confidence: 83%

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

et al. 2020

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“…Composition of intestinal microbiota is linked to adipose tissue browning and insulin action in morbidly obese individuals, possibly via circulating acetate [167]. In grade III obese, the firmicutes RA strain was negatively correlated with serum glycated hemoglobin (HbA1C) and serum triglycerides concentrations and was positively associated with brown adipocyte markers such as the PR domain containing 16 (PRDM16), uncoupling protein 1 (UCP1), and type II iodothyronine deiodinase in subcutaneous adipose tissue.…”

Section: Acetatementioning

confidence: 99%

Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease

Weschenfelder¹,

Quadros²,

Santos³

et al. 2020

Metabolites

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Adipose tissue is a complex structure responsible for fat storage and releasing polypeptides (adipokines) and metabolites, with systemic actions including body weight balance, appetite regulation, glucose homeostasis, and blood pressure control. Signals sent from different tissues are generated and integrated in adipose tissue; thus, there is a close connection between this endocrine organ and different organs and systems such as the gut and the cardiovascular system. It is known that functional foods, especially different nuts, may be related to a net of molecular mechanisms contributing to cardiometabolic health. Despite being energy-dense foods, nut consumption has been associated with no weight gain, weight loss, and lower risk of becoming overweight or obese. Several studies have reported beneficial effects after nut consumption on glucose control, appetite suppression, metabolites related to adipose tissue and gut microbiota, and on adipokines due to their fatty acid profile, vegetable proteins, l-arginine, dietary fibers, vitamins, minerals, and phytosterols. The aim of this review is to briefly describe possible mechanisms implicated in weight homeostasis related to different nuts, as well as studies that have evaluated the effects of nut consumption on adipokines and metabolites related to adipose tissue and gut microbiota in animal models, healthy individuals, and primary and secondary cardiovascular prevention.

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“…As previously described, cross-sectional studies showed negative associations between acetate and fasting insulin in obese women [9]. Similarly, in morbidly obese subjects, a negative association with HOMA-IR and a positive association with insulin sensitivity were observed [10]. Furthermore, acute distal colonic acetate infusions increased fat oxidation and improved metabolic profile in overweight/obese men [6,7].…”

Section: Discussionmentioning

confidence: 68%

“…Recently, a study reported that acetate produced in the distal colon contributes significantly to systemic acetate concentrations in men [8]. In line with this, cross-sectional analyses in patients with obesity have shown positive associations between high circulating acetate and insulin sensitivity indices [9,10]. In women, plasma acetate correlated negatively with fasting and postprandial insulin concentrations [9].…”

Section: Introductionmentioning

confidence: 77%

“…In women, plasma acetate correlated negatively with fasting and postprandial insulin concentrations [9]. In morbidly obese subjects, acetate correlated negatively with Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) [10]. Notably, a resistant starch supplementation (30 g/d for 4 weeks) in healthy subjects increased acetate uptake in muscle and adipose tissue and improved insulin sensitivity (as measured by hyperinsulinemic-euglycemic clamp) [11].…”

Section: Introductionmentioning

confidence: 99%

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The Relationship between Circulating Acetate and Human Insulin Resistance before and after Weight Loss in the DiOGenes Study

et al. 2020

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Microbially-produced acetate has been reported to beneficially affect metabolic health through effects on satiety, energy expenditure, insulin sensitivity, and substrate utilization. Here, we investigate the association between sex-specific concentrations of acetate and insulin sensitivity/resistance indices (Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), circulating insulin and Matsuda Index) in the Diet, Obesity and Genes (DiOGenes) Dietary study at baseline and after a low-calorie diet (LCD, 800 kcal/d). In this analysis, 692 subjects (Body Mass Index >27 kg/m2) were included, who underwent an LCD for 8 weeks. Linear mixed models were performed, which were adjusted for mean acetate concentration, center (random factor), age, weight loss, and fat-free mass (FFM). At baseline, no associations between plasma acetate and insulin sensitivity/resistance indices were found. We found a slight positive association between changes in acetate and changes in HOMA-IR (stdβ 0.130, p = 0.033) in women, but not in men (stdβ −0.072, p = 0.310) independently of age, weight loss and FFM. We were not able to confirm previously reported associations between acetate and insulin sensitivity in this large European cohort. The mechanisms behind the sex-specific relationship between LCD-induced changes in acetate and insulin sensitivity require further study.

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Gut Microbiota Interacts with Markers of Adipose Tissue Browning, Insulin Action and Plasma Acetate in Morbid Obesity

Abstract: Gut microbiota composition is linked to adipose tissue browning and insulin action in morbidly obese subjects, possibly through circulating acetate.

Cited by 82 publications

References 45 publications

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

Detection of Early Disease Risk Factors Associated with Metabolic Syndrome: A New Era with the NMR Metabolomics Assessment

Adipokines and Adipose Tissue-Related Metabolites, Nuts and Cardiovascular Disease

The Relationship between Circulating Acetate and Human Insulin Resistance before and after Weight Loss in the DiOGenes Study

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