Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury

Zou, Ye-Ting; Zhou, Jing; Zhu, Jin-Hao; Wu, Cheng‐Ying; Shen, Hong; Zhang, Wei; Zhou, Shanshan; Xu, Jin–Di; Mao, Qian; Zhang, Yeqing; Long, Fang; Li, Songlin

doi:10.1128/spectrum.00759-22

Cited by 32 publications

(18 citation statements)

References 54 publications

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“…Bioinformatic analysis as sequence alignment, operational taxonomic units (OTUs) picking, clustering, analysis of the beta diversity, and correlation analysis were performed on the Majorbio I-Sanger Cloud Platform (). 40…”

Section: Methodsmentioning

confidence: 99%

Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice

Xie

et al. 2023

Food Funct.

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Section: Methodsmentioning

confidence: 99%

Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice

Xie

et al. 2023

Food Funct.

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“…A traditional Chinese formula, Zengye decoction, attenuates AKI associated with severe acute pancreatitis in rats by modulating gut microbiota. 102 Moreover, fecal microbiota transplant from donor mice treated with the Chinese medicine formula Qiong-Yu-Gao attenuated cisplatin-induced AKI in recipient mice, 103 suggesting that FMT may be an alternative treatment option for AKI. FMT may reduce the accumulation of uremic toxins in subjects with AKI, 104 as the microbial cocktail isolated from feces reduced urea and creatinine concentrations in a mice model of AKI.…”

Section: Treatmentmentioning

confidence: 99%

Gut Microbiota and Neonatal Acute Kidney Injury

Yang,

He,

Dong

2024

Am J Perinatol

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Neonatal acute kidney injury has a complex pathogenesis and the gut microbiota is receiving increasing attention. Gut-kidney axis establishes a bidirectional link between gut microbiota and acute kidney injury. Promoting the study of gut microbiota and neonatal acute kidney injury will contribute to early detection and treatment of this disease. A series of promising biomarkers have emerged in recent years to predict neonatal acute kidney injury earlier than serum creatinine and urine output. However, comprehensive reports on these biomarkers are relatively scarce. In addition, the gut microbiota and biomarkers associated with neonatal acute kidney injury deserve further exploration. Herein, this review summarizes the relationship between gut microbiota and neonatal acute kidney injury biomarkers to deepen our understanding of the role of the gut-kidney axis in neonatal acute kidney injury and provide potential treatment options for neonatal acute kidney injury.

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“…A multicenter randomized controlled clinical trial showed that Chuan Huang Fang formula combined with reduced glutathione can be used to treat AKI (1-2 grades) in CKD patients (2-4 stages) [188]. In addition, Zou et al [189] showed that intestinal flora mediates the protective effect of Qiong-Yu-Gao, a TCM formula, on cisplatin induced AKI by increasing the production of SCFA, thereby inhibiting the expression and activity of histone deacetylase, and reducing the accumulation of uremic toxins. However, it is noted that some TCMs, such as aristolochic acids and alkaloids, are deleterious to the kidney [190].…”

Section: Traditional Chinese Medicine (Tcm)mentioning

confidence: 99%

The Molecular Mechanism and Therapeutic Strategy of Cardiorenal Syndrome Type 3

Liu¹,

Xu²,

Shao³

et al. 2023

Rev. Cardiovasc. Med.

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Cardiorenal syndrome type 3 (CRS3) is defined as acute kidney injury (AKI)-induced acute cardiac dysfunction, characterized by high morbidity and mortality. CRS3 often occurs in elderly patients with AKI who need intensive care. Approximately 70% of AKI patients develop into CRS3. CRS3 may also progress towards chronic kidney disease (CKD) and chronic cardiovascular disease (CVD). However, there is currently no effective treatment. Although the major intermediate factors that can mediate cardiac dysfunction remain elusive, recent studies have summarized the AKI biomarkers, identified direct mechanisms, including mitochondrial dysfunction, inflammation, oxidative stress, apoptosis and activation of the sympathetic nervous system (SNS) and renin-angiotensin-aldosterone system (RAAS), inflammasome, as well as indirect mechanisms such as fluid overload, electrolyte imbalances, acidemia and uremic toxins, which are involved in the pathophysiological changes of CRS3. This study reviews the main pathological characteristics, underlying molecular mechanisms, and potential therapeutic strategies of CRS3. Mitochondrial dysfunction and inflammatory factors have been identified as the key initiators and abnormal links between the impaired heart and kidney, which contribute to the formation of a vicious circle, ultimately accelerating the progression of CRS3. Therefore, targeting mitochondrial dysfunction, antioxidants, Klotho, melatonin, gene therapy, stem cells, exosomes, nanodrugs, intestinal microbiota and Traditional Chinese Medicine may serve as promising therapeutic approaches against CRS3.

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Gut Microbiota Mediates the Protective Effects of Traditional Chinese Medicine Formula Qiong-Yu-Gao against Cisplatin-Induced Acute Kidney Injury

Abstract: Cisplatin-induced acute kidney injury is the main limiting factor restricting cisplatin’s clinical application. Accumulating evidence indicated the important role of gut microbiota in pathogenesis of acute kidney injury.

Cited by 32 publications

References 54 publications

Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice

Structure-specific antitumor effects and potential gut microbiota-involved mechanisms of ginseng polysaccharides on B16F10 melanoma-bearing mice

Gut Microbiota and Neonatal Acute Kidney Injury

The Molecular Mechanism and Therapeutic Strategy of Cardiorenal Syndrome Type 3

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