2020
DOI: 10.21203/rs.2.21492/v2
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Gut microbiota regulates autism-like behavior by mediating vitamin B6 metabolism in EphB6-deficient mice

Abstract: Background Autism spectrum disorder (ASD) is a developmental disorder with limited effective pharmacological treatments for the core autistic symptoms so far. Increasing evidences, especially the clinical studies in ASD patients, suggest a functional link between gut microbiota and development of ASD. However, the mechanisms linking gut microbiota and brain dysfunctions (gut-brain axis) in ASD are still not well-established. With genetic mutations and down-regulated expression in patients with ASD, EPHB6 , whi… Show more

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