GW25-e2125 Gender Difference of Effects for ‘Empty-Nest’ on the Cognition and Its Risk Factors in Healthy China Population above 60 Years Old

Abstract

followed for the incidence of AH and MI. Cox proportional regression model was used for assessment of relative risk (HR) of AH, MI. Results: Low levels of ICC and SNI was revealed in 57.1% and 77.7% of women, respectively. MI was developed in 2.7% of women, AH -in 51%. HR of MI over 16 years of study were in 4.9-fold (95% CI 1.108-21.762; P<0.05) and 2.9-fold (95% CI 1.040-8.208; P<0.05) higher for low ICC and SNI, respectively compared those with higher levels of SS. HR of AH over 5 years was 2.01 (95% CI 1.025-3.938; P<0.05) for low ICC whereas no statistical differences were for low SNI. AH risk in women with low ICC and low SNI within 10 years after the baseline was 1.93 (95% CI 1.138-3.261; P<0.05) and 1.88 (95% CI 1.090-3.255; P<0.05), respectively; over 16 years HR was 1.42 (95% CI 1.138-3.261; P<0.05) and 1.58 (95% CI 1.110-2.274; P<0.01), respectively. There was a tendency of increasing AH and MI incidence rate in married women with low indices ICC, SNI compared to those with higher levels of social support. Those women with higher and vocational education with low SS more likely to have a higher MI rate. Rates of AH were significantly higher in easy physical worker with low SS compared to engineers with low SNI (c 2 ¼4.37 df¼1 P<0.05). There was found a tendency of an increase of AH and MI development in category "executives" and "first-line managers". Conclusions: The prevalence of low SS in women aged 25-64 in Russia is high. Over 16 years of study women with low ICC and SNI have significantly higher risk of MI and AH, especially in married ones occupied in manual class and managers. GW25-e3364MTHFR C677T gene mutation affect the level of plasma homocysteine but do not related to early renal damage in hypertensive patients Objectives: To investigate the possibility that the C677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene may be an independent risk factor for