GW26-e0758 Relationship between Vascular Overload Index and Cardiovascular Structure and Function in Hypertensives

Cai, Xiaoqi; Zhang, Lingyu; Huang, Xiaodong; Shen, Yihua; Xie, Liangdi

doi:10.1016/j.jacc.2015.06.761

Cited by 2 publications

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“…In this study, the correlation between LDH and FMD differed in subgroups based on gender. It was in accordance with our former study, indicating a positive relationship between LDH and intima media thickness of carotid artery only preserved in the male patients with HTN 24 . The diverse results between the gender might be explained by the positive influence of estrogen for female on endothelial function.…”

Section: Discussionsupporting

confidence: 93%

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Lactate dehydrogenase is associated with flow-mediated dilation in hypertensive patients

Cai

Wang

Xie

2023

Sci Rep

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The level of lactate dehydrogenase (LDH) has been proved to be positively associated with albuminuria, which represents glomerular endothelial damage in hypertension (HTN). In this study, the relationship between LDH and endothelial function evaluated by flow-mediated dilation (FMD) was investigated in hypertensives. 1507 subjects (aged 61.2 ± 12.5 years) were enrolled. All hypertensives (n = 1216) were subdivided into 3 groups: LDH1 (lowest tertile of LDH, n = 399), LDH2 (mediate tertile of LDH, n = 409) and LDH3 (highest tertile of LDH, n = 408). Meanwhile, 291 normotensives served as controls. FMD of right anterior tibial artery was assessed by high-resolution color Doppler ultrasound. The level of LDH in hypertensives was significantly higher than normotensives (p < 0.001). Whereas, FMD was obviously more blunted in hypertensives (p < 0.001). There was an increasing trend of FMD < 8% from control, LDH1, LDH2 to LDH3 group (χ2 = 36.751, p < 0.001). Stepwise multiple liner regression analysis demonstrated an independent correlation between LDH and FMD in hypertensives (β = − 0.145, p < 0.05). After stratified analysis, the relevance persisted in the male, young and middle-aged, hypertensives with grade 2 HTN, duration of HTN < 3 years, metabolic syndrome and those without statin therapy. In conclusion, the level of LDH was inversely correlated with FMD among hypertensives. Those hypertensives with increased LDH need to be scanned for target organ damage, such as microalbuminuria and endothelial dysfunction, and more frequent following up are also recommended.

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Section: Discussionsupporting

confidence: 93%

“…In the past decades, we have dedicated to the study of FMD. Several articles 12 , 14 , 24 , 25 , 41 – 43 have been published using anterior tibial artery as target vessel, demonstrating the methodological approach was stable and reproducible.…”

Section: Discussionmentioning

confidence: 99%

Lactate dehydrogenase is associated with flow-mediated dilation in hypertensive patients

Cai

Wang

Xie

2023

Sci Rep

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“…There were two observers in our study, performing for all these measurements, blinding for design of experiment and all information's of subjects, and a statistic specialist analyzing for the data independently. The interobserver and intraobserver coefficient of variation of FMD was 6.92% and 1.90% separately [21,22].…”

Section: Assessment Of Endothelial Functionmentioning

confidence: 99%

Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome

Huang¹,

Cai²,

Zheng³

et al. 2016

J Clin Exp Cardiolog

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Aim: To investigate the association between uric acid (UA) and endothelial function in Chinese hypertensive patients with Metabolic Syndrome (MS).Methods: 615 hypertensive patients were enrolled, all hypertensives were divided into two groups: hypertensives with MS (MS group, n=239) and hypertensives without MS (NMS group, n=376). 87 age-and sex-matched normotensives served as controls (NC group). Flow-mediated (endothelium-dependent) dilatations (FMD), nitroglycerin-induced (endothelium-independent) dilatation (EID) in the brachial artery were assessed by highresolution ultrasonography. UA was detected by urease indophenol. .58)%, p<0.001) among groups. After stratification of gender, lower FMD was only seen in male hypertensives with MS accompanied by hyperuricemia <60 years old ((9.98 ± 5.78)% vs (7.12 ± 4.49)%, p<0.05); Pearson correlation analysis showed that the FMD was negatively correlated with UA (r=-0.314, p<0.01); Finally, logistic regression analysis showed that a 50 µmol/L increase in UA levels carried a 41.1% higher risk for endothelial dysfunction in this cohort. Conclusions: A higher UA level is related to poorer endothelial function in hypertensives with MS. Increased UA can be used as an alternative indicator for monitoring endothelial function and preventing vascular damage in male hypertensives with MS aged less than 60 years old.Keywords: Uric acid; Endothelial dysfunction; Hypertension; Metabolic syndrome InstructionRecently, several studies have indicated that uric acid (UA), the circulating end-metabolite of purine nucleotides of mankind, is associated with subsequent cardiovascular diseases [1,2]. However, it remains controversial whether UA is a relevant and independent risk factor for cardiovascular disease and the mechanisms by which UA results in target organ injury are still unknown. Increasing data suggest that UA is associated with endothelial dysfunction [3,4], which is characteristic of patients with essential hypertension [5]. It is well recognized that endothelial dysfunction is an early stage in atherogenesis and associates with poor cerebro-cardiovascular outcomes [6]. It has been shown that UA disturbs endothelial function by disrupting nitric oxide (NO) synthesis, inhibiting NO bioavailability and activating the renin-angiotensin system.Metabolic syndrome (MS) is believed to be a clustering of abnormalities of several cardiovascular risk factors in an individual including abdominal obesity, hypertension, and dyslipidemia, including low HDL-C, high LDL-C and hyperglycemia. MS is often associated with elevated UA levels [7] and endothelial dysfunction [8,9]. The prevalence of MS has been increasing in recent years in China. A recent epidemiological study showed that the prevalence of MS among Chinese men and women aged 35 to 64 years old was 9.8% and 17.8%, respectively [10]. As is known to all, MS is quite common in patients with primary hypertension and carries much higher risk of cardiovascular events. It was reported that nearly 90% of Chinese hypertensives were ...

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GW26-e0758 Relationship between Vascular Overload Index and Cardiovascular Structure and Function in Hypertensives

Cited by 2 publications

References 0 publications

Lactate dehydrogenase is associated with flow-mediated dilation in hypertensive patients

Lactate dehydrogenase is associated with flow-mediated dilation in hypertensive patients

Relationship between Uric Acid and Endothelial Function in Hypertensive Patients with Metabolic Syndrome

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