Gynura procumbens aqueous extract alleviates nonalcoholic steatohepatitis through CFLAR-JNK pathway in vivo and in vitro

Ya-yun, Liu; You, Jiaojiao; Xu, Wei; Zhai, Tian‐Tian; Du, Chunyuan; Chen, Yong; Han, Fengmei

doi:10.1016/j.chmed.2019.09.005

Cited by 4 publications

(22 citation statements)

References 47 publications

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“…Merr Brightmark Sdn. Bhd, Semenyih, Malaysia + No No Liu Y. et al (2019) Gynura procumbens (Lour.) Merr Shanxi Jintai Biol, China − No Yes—LC-MS/MS Chandradevan et al (2020) Gynura procumbens Net house located in the Malaysia Agricultural, Research and development institute (MARDI) + No Yes— 1 H NMR spectroscopy Wu et al (2013) Gynura bicolor (Roxb.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 17 selected studies ( Siriwatanametanon et al, 2010 ; Kim et al, 2011 ; Akowuah et al, 2012 ; Wu et al, 2013 ; Seow et al, 2014 ; Shwter et al, 2014 ; Chao et al, 2015 ; Wong et al, 2015 ; Yu et al, 2016 ; Yin et al, 2017 ; Yuandani et al, 2017 ; Rahman et al, 2018 ; Sukadeetad et al, 2018 ; Huang et al, 2019 ; Nazri et al, 2019 ; Ning et al, 2019 ; Chandradevan et al, 2020 ) provided the full information about the botanical material and authenticated the Gynura species by depositing voucher specimens. Six selected studies ( Iskander et al, 2002 ; Xu et al, 2015 ; Ma et al, 2017 ; Dong et al, 2019 ; Liu M. et al, 2019 ; Liu Y. et al, 2019 ) reported the information of the Gynura species source but did not provide voucher specimens. Four selected studies ( Siriwatanametanon and Heinrich, 2011 ; Rerknimitr et al, 2016 ; Pai et al, 2019 ; Yang et al, 2019 ) were inadequate on material information as the Gynura species source was not reported and voucher specimens were missing.…”

Section: Resultsmentioning

confidence: 99%

“…Spectroscopic techniques, including UV, IR, and nuclear magnetic resonance (NMR), allow the quantitation of single or multiple compounds that share similarities in their UV absorbance, thus providing a more holistic view of herbal medicines in contrast to the quantitation of a single compound ( Upton et al, 2019 ). Chemical analysis of Gynura species were reported in studies conducted by Kim et al (2011) , Siriwatanametanon and Heinrich (2011) , Wu et al (2013) , Yu et al (2016) , Yuandani et al (2017) , Rahman et al (2018) , Sukadeetad et al (2018) , Dong et al (2019) , Huang et al (2019) , Liu M. et al (2019) , Liu Y. et al (2019) , Nazri et al (2019) , and Chandradevan et al (2020) using methods such as HP-TLC, HPLC, gas chromatography-mass spectrometer, electrospray ionization-mass spectrometry, electrospray ionization time-of-flight mass spectrometry, liquid chromatography with tandem mass spectrometry, ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry, 1 H N 13 C NMR, and 2D-NMR.…”

Section: Resultsmentioning

confidence: 99%

“…Of the 27 selected studies, there are seven species of genus Gynura , which are G. procumbens , G. bicolor , G segetum , G. divaricata , G. formosana , G. nepalensis , and G. pseudochina. Among these Gynura species, 11 out of 27 selected studies focused on G. procumbens ( Iskander et al, 2002 ; Kim et al, 2011 ; Akowuah et al, 2012 ; Shwter et al, 2014 ; Wong et al, 2015 ; Huang et al, 2019 ; Liu M. et al, 2019 ; Liu Y. et al, 2019 ; Nazri et al, 2019 ; Ning et al, 2019 ; Chandradevan et al, 2020 ), five studies on G. bicolor ( Wu et al, 2013 ; Chao et al, 2015 ; Yin et al, 2017 ; Pai et al, 2019 ; Yang et al, 2019 ), four studies on G. pseudochina ( Siriwatanametanon et al, 2010 ; Siriwatanametanon and Heinrich, 2011 ; Rerknimitr et al, 2016 ; Sukadeetad et al, 2018 ), two studies on G. segetum ( Seow et al, 2014 ; Yuandani et al, 2017 ), two studies on G. nepalensis ( Yu et al, 2016 ; Rahman et al, 2018 ), two studies on G. divaricata ( Xu et al, 2015 ; Dong et al, 2019 ), and one study on G. formosana ( Ma et al, 2017 ) .…”

Section: Resultsmentioning

confidence: 99%

“…Five studies used the aqueous extract of G. procumbens and G. bicolor to determine their antioxidant or anti-inflammatory activities in human endothelial cells ( Chao et al, 2015 ), murine adrenal gland pheochromocytoma ( Yang et al, 2019 ), murine hepatocytes ( Liu Y. et al, 2019 ), diabetic mice ( Pai et al, 2019 ), and liver-injured mice ( Yin et al, 2017 ; Liu Y. et al, 2019 ). The ethyl acetate extract of G. formosana was studied for its antioxidant and anti-inflammatory activities in granuloma model rats ( Ma et al, 2017 ).…”

Section: Resultsmentioning

confidence: 99%

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Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

et al. 2020

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Background:Gynura species have been used traditionally to treat various ailments, such as fever, pain, and to control blood glucose level. This systematic review critically discusses studies regarding Gynura species that exhibited antioxidant and anti-inflammatory effects, thus providing perspectives and instructions for future research of the plants as a potential source of new dietary supplements or medicinal agents.Methods: A literature search from internet databases of PubMed, Scopus, Science Direct, e-theses Online Service, and ProQuest was carried out using a combination of keywords such as “Gynura,” “antioxidant,” “anti-inflammatory,” or other related words. Research articles were included in this study if they were experimental (in vitro and in vivo) or clinical studies on the antioxidant or anti-inflammatory effects of Gynura species and if they were articles published in English.Results: Altogether, 27 studies on antioxidant and anti-inflammatory effects of Gynura species were selected. The antioxidant effects of Gynura species were manifested by inhibition of reactive oxygen species production and lipid peroxidation, modulation of glutathione-related parameters, and enzymatic antioxidant production or activities. The anti-inflammatory effects of Gynura species were through the modulation of inflammatory cytokine production, inhibition of prostaglandin E2 and nitric oxide production, cellular inflammatory-related parameters, and inflammation in animal models. The potential anti-inflammatory signaling pathways modulated by Gynura species are glycogen synthase kinase-3, nuclear factor erythroid 2-related factor 2, PPARγ, MAPK, NF-κB, and PI3K/Akt. However, most reports on antioxidant and anti-inflammatory effects of the plants were on crude extracts, and the chemical constituents contributing to bioactivities were not clearly understood. There is a variation in quality of studies in terms of design, conduct, and interpretation, and in-depth studies on the underlying mechanisms involved in antioxidant and anti-inflammatory effects of the plants are in demand. Moreover, there is limited clinical study on antioxidant and anti-inflammatory effects of Gynura species.Conclusion: This review highlighted antioxidant and anti-inflammatory effects of genus Gynura and supported their traditional uses to treat oxidative stress and inflammatory-related diseases. This review is expected to catalyze further studies on genus Gynura. However, extensive preclinical data need to be generated from toxicity and pharmacokinetic studies before clinical studies can be pursued for their development into clinical medicines to treat oxidative stress and inflammatory conditions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

et al. 2020

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Traditional uses, phytochemistry, pharmacology and toxicology of the genus Gynura (Compositae): A comprehensive review

Meng

et al. 2021

Journal of Ethnopharmacology

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Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens

Haque

Kamal

Tahsin

et al. 2021

CTMC

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: Gynura procumbens (Lour.) Merr. is a well-known plant used in the folkloric medicine in tropical Asian countries. The plant is prevalently employed by traditional healers in the treatment of diabetes, cancer, hypertension, inflammation, fever and skin disorders. Several scientific studies reported that, Gynura procumbens possesses considerable therapeutic value for the development of emerging treatment options. The diverse pharmacological effects of this plant are attributed to its vast phytoconstituent content. Different chemical classes including alkaloids, flavonoids, phenolics, steroids, proteins and polysaccharides have been isolated from this plant. In this review, we tried to explore the different aspects of Gynura procumbens as an established medicinal plant. The data gathered here give an indication that the plant Gynura procumbens is a good natural source of chemical compounds with different types of pharmacological actions and these chemical compounds can be used as model for the development of de novo therapeutic agents.

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Gynura procumbens aqueous extract alleviates nonalcoholic steatohepatitis through CFLAR-JNK pathway in vivo and in vitro

Cited by 4 publications

References 47 publications

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

Antioxidant and Anti-Inflammatory Effects of Genus Gynura: A Systematic Review

Traditional uses, phytochemistry, pharmacology and toxicology of the genus Gynura (Compositae): A comprehensive review

Current Knowledge Regarding Pharmacological Profile and Chemical Constituents of Gynura procumbens

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