H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer

Sun, Yihan; Chen, Endong; Li, Yuefeng; Ye, Danrong; Cai, Yefeng; Wang, Qingxuan; Li, Quan; Zhang, Xiaohua

doi:10.1186/s12935-019-0830-1

Cited by 24 publications

(19 citation statements)

References 39 publications

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“…We believe that SNORD63 and SNORD96A play crucial role in the tumorigenesis and development of ccRCC, but the underlying molecular mechanisms needs further studies to illuminate. As described above, snoRNAs are stably expressed and measurable in body fluids, empowering them the potential as biomarkers in various cancer types, such as NSCLC [16][17][18][19][20], CRC [21][22][23][24], breast cancer [25][26][27] and prostate cancer [28][29][30]. In current study, we demonstrated that SNORD63 and SNORD96A acted as the non-invasive diagnostic biomarkers for ccRCC even for early stage ccRCC.…”

Section: Discussionsupporting

confidence: 52%

“…As described above, snoRNAs are stably expressed and measurable in body fluids, empowering them the potential as biomarkers in various cancer types, such as NSCLC [ 16 – 20 ], CRC [ 21 – 24 ], breast cancer [ 25 – 27 ] and prostate cancer [ 28 – 30 ]. In current study, we demonstrated that SNORD63 and SNORD96A acted as the non-invasive diagnostic biomarkers for ccRCC even for early stage ccRCC.…”

Section: Discussionmentioning

confidence: 99%

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SNORD63 and SNORD96A as the non-invasive diagnostic biomarkers for clear cell renal cell carcinoma

et al. 2021

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Background Increasing evidence has demonstrated that snoRNAs play crucial roles in tumorigenesis of various cancer types. However, researches on snoRNAs in ccRCC were very little. This study mainly aimed to validate the differential expression and the potential diagnostic value of SNORD63 and SNORD96A in ccRCC. Methods SnoRNAs expression was downloaded from the SNORic and TCGA database including 516 patients with ccRCC and 71 control cases. SNORD63 and SNORD96A expression were further detected in 54 tumor and adjacent FFPE ccRCC tissues, 55 plasma and 75 urinary sediment of ccRCC patients. Then, differential expression and diagnostic value of SNORD63 and SNORD96A were further calculated. Results SNORD63 and SNORD96A expression were significantly increased in ccRCC tissues compared with normal tissues from the TCGA database (both, P < 0.0001). In addition, we found that SNORD63 and SNORD96A localized in plasma and US stably after treating with RNase A. Meanwhile, SNORD63 and SNORD96A in FFPE and US were elevated in ccRCC patients (all, P < 0.0001). However, plasma SNORD63 expression had no significance while SNORD96A significantly increased in plasma of ccRCC patients. Notably, the AUC of SNORD63 in US was 0.7055, by comparison the AUC of plasma SNORD63 was only 0.5161. However, the AUC of plasma SNORD96A was up to 0.8909, by comparison the AUC of SNORD96A in US was 0.6788. Interestingly, the AUC of plasma SNORD96A in early stage ccRCC was highly up to 0.9359. Conclusions Our findings revealed that SNORD63 in US and SNORD96A in plasma could act as the promising non-invasive diagnostic biomarkers for ccRCC patients.

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Section: Discussionsupporting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

SNORD63 and SNORD96A as the non-invasive diagnostic biomarkers for clear cell renal cell carcinoma

et al. 2021

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“…A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS, [56][57][58] and H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer. 59 Our present results are consistent with these reports and provide novel evidence for an active role of CircMEG3 liver CSCs.…”

Section: Discussionsupporting

confidence: 93%

CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

Jiang

Xing

Chen

et al. 2021

Molecular Therapy - Nucleic Acids

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Circular RNA (CircRNA) is a newly identified special class of non-coding RNA (ncRNA) that plays an important regulatory role in the progression of certain diseases. Herein, our results indicate that CircMEG3 is downregulated expression and negatively correlated with the expression of telomerase-related gene Cbf5 in human liver cancer. Moreover, CircMEG3 inhibits the growth of human liver cancer stem cells in vivo and in vitro. CircMEG3 inhibits the expression of m6A methyltransferase METTL3 dependent on HULC. Moreover, CircMEG3 inhibits the expression of Cbf5, a component of telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst RNA pseudouracil modification) through METTL3 dependent on HULC. Thereby, CircMEG3 inhibits telomerase activity and shortens telomere lifespan dependent on HULC and Cbf5 in human liver cancer stem cell. Strikingly, increased Cbf5 abrogates the ability of CircMEG3 to inhibit malignant differentiation of human liver cancer stem cells. In summary, these observations provide important basic information for finding effective liver cancer therapeutic targets.

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“…Indeed, our work suggests that H/ACA snoRNAs have higher propensity for upregulation in HGSC and are as such more likely to function as positive regulators of cancer cell proliferation and survival. This is consistent with earlier results linking the upregulation of SNORA7B with breast cancer (46) and SNORA42 in lung cancer (47). The link between the upregulation of H/ACA snoRNAs and poor prognosis was also observed in the case of non-small cell lung cancer, where expression of the H/ACA snoRNA binding protein Nop10 was found to drive tumorigenesis (48).…”

Section: Discussionsupporting

confidence: 91%

High-grade Ovarian Cancer Associated H/ACA snoRNAs Promote Cancer Cell Proliferation and Survival

Faucher-Giguère

Roy

Deschamps-Francoeur

et al. 2021

Preprint

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Small nucleolar RNAs (snoRNAs) are an omnipresent class of non-coding RNAs involved in the modification and processing of ribosomal RNA (rRNA). As snoRNAs are required for ribosome production, the increase of which is a hallmark of cancer development, their expression would be expected to increase in proliferating cancer cells. However, the nature and extent of snoRNAs contribution to the biology of cancer cells remain largely unexplored. In this study, we examined the abundance patterns of snoRNA in high-grade serous ovarian carcinomas (HGSC) and serous borderline tumours (SBT) and identified a subset of snoRNA associated with increased invasiveness. This subgroup of snoRNA accurately discriminates between SBT and HGSC underlining their potential as biomarkers of tumour aggressiveness. Remarkably, knockdown of HGSC-associated H/ACA snoRNAs, but not their host genes, inhibits cell proliferation and induces apoptosis of model ovarian cancer cell lines. Wound healing and cell migration assays confirmed the requirement of these HGSC-associated snoRNA for cell invasion and increased tumour aggressiveness. Together our data indicate that H/ACA snoRNAs promote tumour aggressiveness through the induction of cell proliferation and resistance to apoptosis.

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H/ACA box small nucleolar RNA 7B acts as an oncogene and a potential prognostic biomarker in breast cancer

Cited by 24 publications

References 39 publications

SNORD63 and SNORD96A as the non-invasive diagnostic biomarkers for clear cell renal cell carcinoma

SNORD63 and SNORD96A as the non-invasive diagnostic biomarkers for clear cell renal cell carcinoma

CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells

High-grade Ovarian Cancer Associated H/ACA snoRNAs Promote Cancer Cell Proliferation and Survival

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