H<sub>2</sub>O<sub>2</sub>-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Wang, Yang; Liang, Xufeng; An, Jian; Pu, Jia; Meng, Yujia; Bai, Yiqiao; Yu, Wenqiang; Gao, Yunhan; Chen, Tingting; Yao, Yong

doi:10.1039/d4cc01485e

Chem. Commun.

2024

DOI: 10.1039/d4cc01485e

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H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Yang Wang,

Xufeng Liang,

Jian An

et al.

Abstract: A novel H2O2-responsive carbon monoxide nanogenerator was designed by effectively encapsulating manganese carbonyl prodrug into porphyrinic covalent organic polymers for realizing the combined CO gas and photodynamic therapy under near...

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Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy

Li,

Zhao,

Liu

et al. 2024

ACS Appl. Nano Mater.

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The special pathological microenvironment of infected wounds (pathology of weakly acidic, hypoxic, and overexpressed H 2 O 2 ) provides fertile soil for the development of disease. Tailoring treatment based on the specific characteristics of the infectious microenvironment (IME) has emerged as a novel direction in the development of antimicrobial therapies. Here, a polyoxovanadate (POV)-based covalent organic polymer (POV-Fc-COP) with inherent photothermal activity was facilely prepared via the copolymerization of 1,1′-bi(3-dimethylamino-1-oxo-2-enylferrocene) (BDOEF) with tris-NH 2 -modified POV (tris-V 6 O 9 ), in which the nanovanadium oxide (V 2 O 3 and V 2 O 5 ) core and polymer shell were generated directly during the Michael addition−elimination reaction. The unique structure and composition impart pH-responsive peroxidase-like (POD-like) and catalase-like (CAT-like) activities, concurrently, to the POV-Fc-COP. Specifically, the acid-activated mimicking-POD activity could consume H 2 O 2 in the microenvironment, producing toxic •OH to combat bacteria and biofilms. The vanadium oxide consumes the excessive acid, resulting in an increase in pH. Meanwhile, the CATlike activity could transform excess H 2 O 2 expression into O 2 to relieve hypoxia induced by the damage of blood vessels in the wounds and facilitate wound healing. Additionally, the synergistic amplified therapeutic effect triggered by the application of laser irradiation facilitates the rapid eradication of bacteria and biofilm, minimizing the detrimental impacts of bacterial proliferation on the IME, thereby accelerating the restoration of the IME return to a normal state. Therefore, POV-Fc-COP with a dual-enzyme functionality could not only utilize but also regulate the IME, significantly expediting the healing of bacteria-infected wounds. This study demonstrates a simple method for the preparation of an intelligent platform for programmed antibacterial and antibiofilm formation, thus promoting healing while utilizing and improving the IME.

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Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy

Li,

Zhao,

Liu

et al. 2024

ACS Appl. Nano Mater.

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GalNAc-modified FeS nanoparticles for specific chemodynamic and gas therapy against orthotopic hepatocellular carcinoma

Li,

Song,

Yin

et al. 2024

Chem. Commun.

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Manganese carbonyl-encapsulated Fe-MOFs as a H₂O₂-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy

Wang,

An,

Zhang

et al. 2025

New J. Chem.

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H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Abstract: A novel H2O2-responsive carbon monoxide nanogenerator was designed by effectively encapsulating manganese carbonyl prodrug into porphyrinic covalent organic polymers for realizing the combined CO gas and photodynamic therapy under near...

Cited by 3 publications

References 40 publications

Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy

Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy

GalNAc-modified FeS nanoparticles for specific chemodynamic and gas therapy against orthotopic hepatocellular carcinoma

Manganese carbonyl-encapsulated Fe-MOFs as a H₂O₂-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy

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About

H2O2-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Abstract: A novel H2O2-responsive carbon monoxide nanogenerator was designed by effectively encapsulating manganese carbonyl prodrug into porphyrinic covalent organic polymers for realizing the combined CO gas and photodynamic therapy under near...

Cited by 3 publications

References 40 publications

Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy

Multifunctional Polyoxovanadate-Based Covalent Organic Polymer for Bacteria-Infected Wound Therapy

GalNAc-modified FeS nanoparticles for specific chemodynamic and gas therapy against orthotopic hepatocellular carcinoma

Manganese carbonyl-encapsulated Fe-MOFs as a H2O2-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy

Contact Info

Product

Resources

About

H₂O₂-triggered CO release based on porphyrinic covalent organic polymers for photodynamic/gas synergistic therapy

Manganese carbonyl-encapsulated Fe-MOFs as a H₂O₂-responsive CO gas nanogenerator for synergistic gas/chemodynamic therapy