H2O2/Ca2+/Zn2+ Complex Can Be Considered a “Collaborative Sensor” of the Mitochondrial Capacity?

Filippo, Ester Sara Di; Checcaglini, F; Fanò-Illic, Giorgio; Fulle, Stefania

doi:10.3390/antiox11020342

Cited by 7 publications

(4 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In particular, Zn 2+ -associated signalling pathways are involved in the development of diabetic cardiomyopathy and other heart diseases [6,7]. In that regard, the close coordination of [Ca 2+ ] i and [Zn 2+ ] i homeostasis in mitochondrion balances the redox status and oxidative stress status of cardiomyocytes and provides a cardioprotective effect [8].…”

Section: Introductionmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

View full text Add to dashboard Cite

Zinc plays an important role in cardiomyocytes, where in exists in bound and histochemically reactive labile Zn2+ forms. Although Zn2+ concentration is under tight control through several Zn2+-transporters, its concentration and intracellular distribution may vary during normal cardiac function and pathological conditions, when the protein levels and efficacy of Zn2+ transporters can lead to zinc re-distribution among organelles in cardiomyocytes. Such dysregulation of cellular Zn2+ homeostasis leads to mitochondrial and ER stresses, and interrupts normal ER/mitochondria cross-talk and mitophagy, which subsequently, result in increased ROS production and dysregulated metabolic function. Besides cardiac structural and functional defects, insufficient Zn2+ supply was associated with heart development abnormalities, induction and progression of cardiovascular diseases, resulting in accelerated cardiac ageing. In the present review, we summarize the recently identified connections between cellular and mitochondrial Zn2+ homeostasis, ER stress and mitophagy in heart development, excitation–contraction coupling, heart failure and ischemia/reperfusion injury. Additionally, we discuss the role of Zn2+ in accelerated heart ageing and ageing-associated rise of mitochondrial ROS and cardiomyocyte dysfunction.

show abstract

Section: Introductionmentioning

confidence: 99%

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

View full text Add to dashboard Cite

show abstract

“…It has previously been shown that the age-dependent increase in oxidative damage in muscle of healthy subjects may reflect either increased free radical production or insufficient activity of scavenger/repair systems. 57 Histological and molecular data on skeletal muscle from Long-COVID patients are currently very limited. They are mainly based on case reports and are insufficient to define an established hypothesis.…”

Section: Oxidative Stress In Skeletal Muscle Of Long-covid Patientsmentioning

confidence: 99%

Effect of physical activity on long COVID fatigue: an unsolved enigma

Coscia,

Di Filippo,

Gigliotti

et al. 2023

Eur J Transl Myol

Self Cite

View full text Add to dashboard Cite

Covid-19 disease is well documented and often the most common symptoms include myalgia and muscle fatigue. Approximately 10% of those infected complain of persistent fatigue even many months after the end of the acute phase of the disease. This gives rise to a condition different from the previous one and commonly known as 'post-acute COVID-19 syndrome' or simply Long-COVID. Although the origin of muscle fatigue is multifactorial, the state of prolonged fatigue observed in the Long-COVID syndrome suggests the existence of a possible state of atrophy or rather acute sarcopenia. Under these conditions, the use of physical activity programs can effectively counteract the state of atrophy underlying the fatigue phenomena observed. If this is also the situation during the Long-COVID, the muscular symptom should be positively influenced by the administration of programmed physical activity cycles. In fact, in patients with Long-COVID, the few published papers seem to indicate that patients who are physically active and who make an effort to engage in physical activity even during the illness have decreased duration and intensity of the illness. However, analysis of the studies in the literature also suggests that a small percentage of people with Long-COVID do not appear to benefit from the application of physical activity programs, so further studies on homogeneous samples are needed to provide a firm answer to the question: can planned physical activity help patients during the pathological course of Long-COVID?

show abstract

“…It is known that Zn 2+ -associated signalling pathways are involved in the development of diabetic cardiomyopathy and other heart diseases. Mitochondria coordinate [Ca 2+ ] i and [Zn 2+ ] i homeostasis, which affect cellular ROS production, mitochondria ultrastructure and efficiency [106,107]. The role of Zn 2+ homeostasis in DM and obesity-induced cardiac remodelling, inflammation, dysfunction and other cardiovascular diseases and complications was covered in several recent reviews [108][109][110].…”

Section: Zinc Supplementation In Dm Treatment and Cardioprotectionmentioning

confidence: 99%

The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy

Dabravolski

Sadykhov

Kartuesov

et al. 2022

IJMS

View full text Add to dashboard Cite

Diabetic cardiomyopathy (DCM) is defined as the presence in diabetic patients of abnormal cardiac structure and performance (such as left ventricular hypertrophy, fibrosis, and arrhythmia) in the absence of other cardiac risk factors (such as hypertension or coronary artery disease). Although the pathogenesis of DCM remains unclear currently, mitochondrial structural and functional dysfunctions are recognised as a central player in the DCM development. In this review, we focus on the role of mitochondrial dynamics, biogenesis and mitophagy, Ca2+ metabolism and bioenergetics in the DCM development and progression. Based on the crucial role of mitochondria in DCM, application of mitochondria-targeting therapies could be effective strategies to slow down the progression of the disease.

show abstract

H2O2/Ca2+/Zn2+ Complex Can Be Considered a “Collaborative Sensor” of the Mitochondrial Capacity?

Cited by 7 publications

References 74 publications

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Interplay between Zn2+ Homeostasis and Mitochondrial Functions in Cardiovascular Diseases and Heart Ageing

Effect of physical activity on long COVID fatigue: an unsolved enigma

The Role of Mitochondrial Abnormalities in Diabetic Cardiomyopathy

Contact Info

Product

Resources

About