Habituation measured by pattern reversal visual evoked potentials depends more on check size than reversal rate

Omland, Petter Moe; Nilsen, Kristian Bernhard; Sand, Trond

doi:10.1016/j.clinph.2011.02.025

Cited by 16 publications

(26 citation statements)

References 67 publications

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“…This decrement is often referred to as habituation (Bednar et al, 2014). This interpretation is also used in the present study, although there are other possible explanations for the amplitude decrement (Omland et al, 2011). Some groups have reported that VEP amplitudes do not decline in migraineurs in the period between attacks (interictally) (Bednar et al, 2014;Coppola et al, 2009;Ozkul and Bozlar, 2002).…”

Section: Introductionmentioning

confidence: 63%

“…8' and 16' checks) than larger check sizes (e.g. 65') in both controls and migraineurs (Omland et al, 2011;Omland et al, 2013), whereas very small check sizes (e.g. 8') may result in a low signal to noise ratio in some subjects (Sand and Vingen, 2000).…”

Section: Introductionmentioning

confidence: 89%

“…VEP amplitude declines during repeated stimulation in controls (Omland et al, 2011;Omland et al, 2013). This decrement is often referred to as habituation (Bednar et al, 2014).…”

Section: Introductionmentioning

confidence: 92%

“…For instance, in some studies the amplitude reduction is considered a result of sensory adaptation (Heinrich and Bach, 2001;Heinrich and Bach, 2002). The relative effect of sensory adaptation and habituation cannot be separated with the methods commonly applied in migraine habituation studies (Omland et al, 2011). It is also likely that changes in concentration could influence VEP amplitudes, although VEP amplitude decrement during stimulation unrelated to lack of attention and alertness have been reported (Skuse and Burke, 1992).…”

Section: Progressive Amplitude Changes During Recoding Of Vepmentioning

confidence: 99%

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Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Omland

Uglem

Hagen

et al. 2016

Clinical Neurophysiology

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Please cite this article as: Omland, P.M., Uglem, M., Hagen, K., Linde, M., Tronvik, E., Sand, T., Visual evoked potentials in migraine: Is the "neurophysiological hallmark" concept still valid ?, Clinical Neurophysiology (2015), doi: http://dx.doi.org/10. 1016/j.clinph.2014.12.035 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. • Lack of VEP habituation is not a reliable "neurophysiological hallmark" in interictal migraine• Strict focus on methodology, including blinding during the recording and assessment of VEP, is important to avoid overestimation of effect sizes in future studies.2 Abstract Objective Lack of habituation is considered a neurophysiological hallmark of migraine. However, the results of visual evoked potential (VEP) studies have been discrepant, possibly because of different stimulation parameters and lack of blinding. Hence, there is a need for independent confirmation of lack of VEP habituation in migraine. In this blinded study we applied 16' checks to supplement our previous findings with 8', 31', 62' and 65' checks. MethodsVEPs in 41 interictal migraineurs and 30 controls were compared. VEPs were recorded in six blocks of 100 single responses. Linear N70-P100 amplitude change over blocks (habituation slope) was compared with an independent samples Student's t-test. ResultsAmplitude decline over blocks was observed in both groups. Habituation slope was not significantly different between controls (-0.43 ± 0.54 μV/block) and migraineurs (-0.29 ± 0.35 μV/block) (p = 0.33). ConclusionVEP habituation with 16' checks did not differ in migraineurs and controls. This is in agreement with previous findings with other stimulation parameters. It is therefore unlikely that use of different stimulation parameters could explain the discrepant results of previous studies. No studies that applied blinding during recording of VEP have found lack of habituation in migraineurs. SignificanceLack of VEP habituation cannot be considered a reliable neurophysiological hallmark in migraine.

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Section: Introductionmentioning

confidence: 63%

Section: Introductionmentioning

confidence: 89%

“…VEP amplitude declines during repeated stimulation in controls (Omland et al, 2011;Omland et al, 2013). This decrement is often referred to as habituation (Bednar et al, 2014).…”

Section: Introductionmentioning

confidence: 92%

Section: Progressive Amplitude Changes During Recoding Of Vepmentioning

confidence: 99%

See 2 more Smart Citations

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Omland

Uglem

Hagen

et al. 2016

Clinical Neurophysiology

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“…16 Such disseminated lesions may disrupt multiple brain areas responsible for normal habituation phenomena. It has been suggested that different properties such as check size and reversal rate of the magnocellular and parvocellular systems may be important for PR-VEP habituation 17 but in our study, we used the same laboratory and electrophysiological procedures for both patient and control groups.…”

Section: Visual Habituation In Msmentioning

confidence: 99%

Lack of Visual Habituation in Multiple Sclerosis: An Electrophysiological Study

Bir

Değirmenci

Erdoǧan

2013

Neuro-Ophthalmology

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In this study, we aimed to investigate habituation of pattern-reversal visually evoked potentials (VEPs) in patients with relapsing remitting (RR) multiple sclerosis (MS). Twenty-one patients with this diagnosis and with a history of optic neuritis (ON), 29 such patients without a history of ON, and 25 normal controls were enrolled to study. One eye of each patient in the group with a history of ON and one eye of each subject in the control group was randomly selected. In the group with a past history of ON, the affected eye of the patients was selected in unilateral cases and the eye in which showed the greater latency delay of the P100 component in bilateral cases. P100 amplitudes were determined by visual inspection in 10 blocks of 512 responses and habituation was analysed as the percentage amplitude change between the 1st and 2nd-10th blocks. Amplitude of the P100 component of the VEP showed a significant clear-cut habituation after the first block in the control group but neither patient group showed a significant decrease in P100 amplitude. We conclude that our electrophysiological study has shown a lack of habituation in patients suffering from RR MS. This result could be important for the evaluation of visual system involvement in patients with MS, with or without a previous history of ON.

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Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

et al. 2011

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A lack of habituation in visual-evoked potentials (VEPs) is the main abnormality observed in migraineurs. However, no study of steady-state VEPs has yet evaluated pattern-reversal stimuli with respect to habituation behavior or spatial frequency. The aim of this study was to clarify habituation behavior in migraineurs between attacks and to establish characteristics of VEPs in these patients. Steady-state VEPs were sequentially recorded as checkerboard patterns in four consecutive blocks from 12 patients with migraine without aura (MO), 12 patients with migraine with aura (MA), and 12 healthy controls (HC) at four spatial frequencies of 0.5, 1.0, 2.0, and 4.0 cycles per degree (cpd) with a stimulus rate of 7.5 Hz (15 reversal/s). VEP amplitudes were consistently higher in migraineurs. However, habituation was not demonstrated in HCs, and migraineurs did not reveal a clear lack of habituation. MAs exhibited high-amplitude VEPs, depending on spatial frequency. In the MA patients, amplitude differences reached statistical significance at 2.0 cpd. The sequential amplitude changes at 0.5 cpd were significantly different in MAs compared with HCs. Migraine patients exhibited high-amplitude VEPs, which were dependent on spatial frequency, and may be related to altered excitability in pre-cortical and cortical visual processing.

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Habituation measured by pattern reversal visual evoked potentials depends more on check size than reversal rate

Cited by 16 publications

References 67 publications

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Visual evoked potentials in migraine: Is the “neurophysiological hallmark” concept still valid?

Lack of Visual Habituation in Multiple Sclerosis: An Electrophysiological Study

Spatial frequency differentially affects habituation in migraineurs: a steady-state visual-evoked potential study

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