2024
DOI: 10.1002/advs.202405147
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HADHA Regulates Respiratory Complex Assembly and Couples FAO and OXPHOS

Chaoying Qin,
Shasha Gong,
Ting Liang
et al.

Abstract: Oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) are key bioenergetics pathways. The machineries for both processes are localized in mitochondria. Secondary OXPHOS defects have been documented in patients with primary FAO deficiencies, and vice versa. However, the underlying mechanisms remain unclear. Intrigued by the observations that regulation of supercomplexes (SCs) assembly in a mouse OXPHOS deficient cell line and its derivatives is associated with the changes in lipid metabolism, a prot… Show more

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