Haemangioma at the Optic Disc

Oosterhuis, J. A.; Rubinstein, K

doi:10.1159/000306773

Cited by 32 publications

(4 citation statements)

References 3 publications

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“…RCHs commonly occur as peripheral tumors in the retina, most frequently in the superotemporal or inferotemporal quadrants and are associated with prominent feeder vessels. In 11–15% of cases they occur in a juxtapapillary location 5 . Complications of RCHs are commonly macular or extramacular fluid and lipid exudation, epimacular membrane formation, exudative retinal detachment, tractional retinal detachment, vitreous hemorrhage and neovascular glaucoma.…”

Section: Discussionmentioning

confidence: 99%

Retinal capillary hemangioblastoma and hemiretinal vein occlusion in a patient with primary congenital glaucoma: A case report

AlBloushi

Taşkintuna

Nowilaty

2019

Saudi Journal of Ophthalmology

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The presence of retinal capillary hemangioblastoma and cerebellar hemangioblastoma in the context of Von Hippel-Lindau syndrome (VHL) is not characteristically associated with other ophthalmologic conditions. Here, we report the case of a 22-yearold female with a history of bilateral primary congenital glaucoma who presented with a right juxtapapillary retinal capillary hemangioblastoma and an old hemiretinal vein occlusion in which the retinal capillary hemangioblastoma was likely the contributing factor. Her systemic work up was positive for VHL syndrome and revealed the presence of a fatal large brainstem hemangioblastoma. To our knowledge, the association of VHL and congenital glaucoma and/or retinal venous occlusion has not been reported.

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Section: Discussionmentioning

confidence: 99%

Retinal capillary hemangioblastoma and hemiretinal vein occlusion in a patient with primary congenital glaucoma: A case report

AlBloushi

Taşkintuna

Nowilaty

2019

Saudi Journal of Ophthalmology

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“…Abnormal blood vessels were not visible on the disc, although intravenously administered fluorescein showed immediate leakage at the disc. MacMichael (1970) and Oosterhuis and Rubinstein (1972) have provided excellent reviews of yon Hippel lesions of the disc, the former including another bilateral case. Disc involvement usually does not coexist with peripheral retinal lesions.…”

Section: Angiomatous Tumors and Malformationsmentioning

confidence: 99%

Tumors of the optic nerve

1976

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This is a review of primary and secondary tumors of the optic nerve. The emphasis is an optic nerve gliomas and meningiomas. Optic nerve gliomas are slowly growing astrocytic neoplasms of the anterior visual pathways, the majority of which occur within the first two decades of life, with equal sex incidence in about 1 of 200,000 patients presenting with eye complaints. The incidence is greater in neurofibromatosis. The typical presentation is visual impairment in a verbal pre-school child with optic canal enlargement and optic atrophy. An intraorbital location of the tumor leads to axial, irreducible, non-pulsatile proptosis. An intracranial location may disturb hypothalamic and pituitary function and produce hydrocephalus. Ocular findings may also include limited motility on a mechanical-restrictive basis, a pupillary relative afferent defect, nystagmus, and variable, non-specific visual field defects. Roentgenographic studies may show concentric unilateral enlargement of the optic canal with preservation of a well corticated margin, a fossa under the anterior clinoid process in continuity with the optic canal ('J'-shaped sella), and findings of increased intracranial pressure. On pathologic examination the tumor is a smooth, fusiform, intradural enlargement of the optic nerve. Histologically there is proliferation of elongated (pilocytic) astrocytes in reticulated patterns with intervening microcystic spaces containing mucosubstance and surrounding reactive hyperplasia of the arachnoid. Mitoses are not found. The diagnosis is clinical X-ray studies and brain scan should be performed. The differential diagnosis is that of unilateral proptosis in a child and includes acute ethmoiditis, hyperthyrobidism, craniostenosis, other neoplasms, Hand-Schuller-Christian disease, and orbital hemorrhage due to trauma. Surgical resection is performed in cases with unilateral optic nerve involvement, the surgical approach being determined by tumor location. Bilateral or chiasmal cases are treated with radiotherapy when progression occurs. Malignant optic nerve gliomas and optic nerve hyperplasia are also discussed. Optic nerve meningiomas arise from the nerve sheath and are to be distinguished from orbital meningiomas arising from ectopic arachnoidal cells or those secondarily involving the orbit by extension from adjacent sites. Up to 80% of orbital meningiomas occur in females, in two age peaks, 25% in the first decade, and the rest in the 5th decade. Meningiomas present with visual loss and may produce proptosis, papilledema and/or optic atrophy, retinal striae, opticociliary shunts, limitation of extra-ocular movements, and lid edema, Signs of von Recklinghausen's disease should be sought. X-rays are the mainstay of diagnosis. Orbital meningiomas are composed of cells in sheets or in whorls with some spindle shaped cells. Calcifications are typical. Usually the dura is penetrated and the orbit invaded. Primary orbital meningiomas are locally infiltrating but do not metastasize. Complete local excision en bloc is recommended...

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“…The multifocal and bilateral involvement of RCH in VHL disease poses a therapeutic challenge. Various treatment modalities have been reported including observation, laser photocoagulation, cryotherapy, plaque radiotherapy, trans‐scleral penetrating diathermy, and vitreoretinal surgery, with varying and limited success depending on tumour characteristics (Welch 1970; Oosterhuis & Rubinstein 1972; Cardoso & Brockhurst 1976; Gass & Braunstein 1980; Lane et al. 1989; Blodi et al.…”

Section: Introductionmentioning

confidence: 99%

Verteporfin photodynamic therapy of six eyes with retinal capillary haemangioma

Sachdeva

Dadgostar

Kaiser

et al. 2010

Acta Ophthalmologica

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Acta Ophthalmol. 2010: 88: e334–e340 Abstract. Purpose: Single‐centre consecutive interventional case series by retrospective chart review to evaluate the efficacy of verteporfin (Visudyne™) photodynamic therapy (PDT) of retinal capillary haemangioma (RCH). Methods: Following an initial period of observation, six eyes of five patients with RCH (juxtapapillary 3 and extrapapillary (EP) 3) received 1–3 sessions of standard verteporfin PDT upon the development of progressive vision‐threatening complications. Four of the five patients had von Hippel‐Lindau (VHL) disease. Follow‐up included documentation of best‐corrected Snellen visual acuity (BCVA), tumour regression, and presence or absence of subretinal fluid (SRF) and/or lipid exudation as assessed by dilated fundus examination (DFE), fundus photos, and optical coherence tomography (OCT). These parameters were documented at 1 week, 1 month, and 3 months following each PDT session and up to 32 months following the first PDT. Results: All eyes showed favourable response to PDT as defined by tumour regression or stabilization as well as improvement of SRF and lipid exudation. BCVA improved or stabilized in three eyes. Three eyes required PDT retreatment for recurrent SRF. Epiretinal membrane (ERM) worsened in three eyes, requiring vitreoretinal surgery at a median of 6 months following PDT. Conclusions: PDT is a moderately effective treatment for juxtapapillary and EP RCH. In this series, PDT resulted in tumour regression or stabilization as well as in the improvement of SRF and lipid exudation in all cases. However, stabilization or improvement of visual acuity was observed in only 50 per cent of the cases. The treatment benefits may be limited by pre‐existing macular changes and worsening of ERM. A larger prospective study is necessary to validate these findings.

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Haemangioma at the Optic Disc

Cited by 32 publications

References 3 publications

Retinal capillary hemangioblastoma and hemiretinal vein occlusion in a patient with primary congenital glaucoma: A case report

Retinal capillary hemangioblastoma and hemiretinal vein occlusion in a patient with primary congenital glaucoma: A case report

Tumors of the optic nerve

Verteporfin photodynamic therapy of six eyes with retinal capillary haemangioma

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