Haematological, Biochemical and Toxicological Investigations in Spontaneous Cases with Different Frequency of Porcine Nephropathy in Bulgaria

Stoev, Stoycho D.; Stoeva, J. K.; Anguelov, G.; Hald, Birthe; Creppy, E. E.; Radić, Božica

doi:10.1111/j.1439-0442.1998.tb00822.x

Cited by 44 publications

(57 citation statements)

References 13 publications

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“…Keeping in mind the low contamination levels of OTA in serum, tissue and feed of chickens with nephropathy, we can conclude that the chicken nephropathy, similarly to porcine nephropathy in Bulgaria [26,27], may have a multitoxin or multifactor aetiology, because it cannot be explained by the concentration/action of OTA alone. Detailed investigations have to be made to identify the cause of nephropathy in chickens.…”

Section: Discussionmentioning

confidence: 92%

“…While agreeing that the most important toxicological target of OTA in the pig is the kidney, the principal descriptions of the pathology of MNC vary considerably. Moreover, the clinico-morphological picture of spontaneous MNC in Bulgaria differs significantly from the classical description of the nephropathy made in Scandinavia [5] and is also encountered in the same regions of the country where a mycotoxic porcine nephropathy is evident, which supposes the same multicausal nature [26,27]. Therefore, it was necessary to elucidate the aetiology of this nephropathy and to describe in full its clinicomorphological picture.…”

Section: Introductionmentioning

confidence: 93%

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Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

et al. 2002

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-Histopathological, biochemical and toxicological investigations of tissues and blood of normally slaughtered chickens exhibiting different frequencies (1-2%, 40-50% and above 80%) of nephropathy changes (congested or pale and enlarged kidneys) at the slaughtering meat inspection were carried out to elucidate the aetiology of nephropathies of chickens encountered in Bulgaria. A close relationship was observed between the frequency of this nephropathy and the rate of nephrotoxic mycotoxin ochratoxin A in muscles, kidneys and livers of chickens, but the levels of ochratoxin A in corresponding feed samples (0.1-0.3 ppm) were significantly lower than the levels (2-4 ppm) required to reproduce such nephropathy. Clinicomorphological changes such as nervous symptoms, vascular and oedematous changes in various internal organs and the brain, and subcutaneous or liver and kidney haemorrhages in addition to known degenerative changes in the kidneys, liver and lymphoid organs differed from the classical description of the nephropathy made in Scandinavia. The conclusion is that the Bulgarian chicken nephropathy may have a multitoxic aetiology because it cannot be explained by the concentration of ochratoxin A alone. mycotoxic nephropathy / ochratoxicosis / mycotoxin / ochratoxin A / pathology Résumé -Néphropathie mycotoxique spontanée sans étiologie mycotoxique déterminée chez des poulets bulgares. Des études histopathologiques, biochimiques et toxicologiques des tissus et du sang de poulets montrant des fréquences variées (1-2 %, 40-50 % et supérieures à 80 %) de changements néphropathiques (reins congestionnés ou pâles et hypertrophiés) lors de l'inspection des viandes à l'abattoir, ont été entreprises afin de déterminer l'étiologie des néphropathies du poulet en Bulgarie. Une relation étroite a été observée entre la fréquence de cette néphropathie et le taux de la

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 93%

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

et al. 2002

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“…Studies with pigs about blood glucose levels after OTA toxication are contradictory (28)(29)(30)(31). When rabbits fed with 1 and 2 ppm OTA contaminated food, a decrease in blood glucose level observed after 3 weeks and at week 8, blood glucose level was half of the control group (32).…”

Section: Discussionmentioning

confidence: 99%

Diabetogenic Effects of Ochratoxin A in Female Rats

Mor

Sengul

Topsakal

et al. 2017

Preprint

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Abstract:In this study, diabetogenic effects of long term Ochratoxin A (OTA) administration in rats were investigated and its role in the etiology of diabetes mellitus (DM) was examined utilizing 42 female Wistar rats for these purposes. The rats were divided into 3 different study and control groups according to the duration of the OTA administration. Rats received 45 μg OTA daily in their feed for 6, 9 and 24 weeks study groups. Three control groups without any treatment were also used in the same periods. Blood and pancreatic tissue samples were collected during the necropsy at the end of 6, 9 and 24 weeks. Plasma values of insulin, glucagon and glucose in study and control groups were determined. Pancreatic lesions were evaluated by histopathological examination; then insulin and glucagon expression in these lesions were determined by immunohistochemical methods. Statistically significant decrease in insulin levels in contrast to increases in glucagon and glucose levels in blood were observed. Slight to moderate degeneration in Langerhans islet cells were observed at the histopathological examination in all OTA treated groups. Immunohistochemistry of pancreatic tissue revealed decreased insulin and increased glucagon expression. This study demonstrated that OTA may cause pancreatic damage in Langerhans islet and predispose rats to DM.

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“…OTA exhibits nephrotoxic (STOEV et al 1998), teratogenic, hepatotoxic (KUIPER-GOODMAN & SCOTT 1989), genotoxic (CREPPY et al 1985 and immunotoxic (LEA et al 1989) effects which were observed mainly in animals. OTA has been linked also with a human disease -Balkan endemic nephropathy (CASTEGNARO et al 1987).…”

Section: Discussionmentioning

confidence: 99%

Fungal contamination and the levels of mycotoxins (Don and Ota) in cereal samples from poland and east slovakia

Čonková¹,

Laciakova²,

ŠtyriakI³

et al. 2006

Czech J. Food Sci.

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The cereal samples were taken immediately after harvest from the selected localities of Poland (45 samples) and East Slovakia (60 samples). Fungal contamination of these samples was investigated and subsequently the presence of two important mycotoxins, deoxynivalenol (DON) and ochratoxin A (OTA), was quantitatively examined. Concerning mould contamination, no difference was observed between the samples from Poland and East Slovakia. The highest incidence was observed of Fusarium, Aspergillus, and Penicillium genera. However, most of the investigated samples of wheat, rye, and barley contained less than 10 4 cfu/g. The limit 750 ppb for DON in cereals and their products, recommended by the European Mycotoxin Awareness Network (EMAN), was exceeded only by one wheat sample (4.5%) from Poland, but by seven wheat samples (14.6%) from Slovakia. None cereal sample investigated for OTA exceeded the allowed limit -5 µg/kg.

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Haematological, Biochemical and Toxicological Investigations in Spontaneous Cases with Different Frequency of Porcine Nephropathy in Bulgaria

Cited by 44 publications

References 13 publications

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

Spontaneous mycotoxic nephropathy in Bulgarian chickens with unclarified mycotoxin aetiology

Diabetogenic Effects of Ochratoxin A in Female Rats

Fungal contamination and the levels of mycotoxins (Don and Ota) in cereal samples from poland and east slovakia

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