Haematological Study on the Effects of Goko Cleanser (Herbal Mixture) on Adult Female Wistar Rats

Onyejike, Darlington Nnamdi; McWilliams, Winifred Chidera; Mmaju, Chidinma Ifeyinwa; Okeke, Somadina Nnamdi; Obiesie, Ifechukwu Justicia; Eze, Chinyere Elizabeth

doi:10.9734/ibrr/2021/v12i130141

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…This may be attributed to the phytochemical constituents of the plant composition of the Dr Iguedo Goko Cleanser®. For instance, Onyejike et al [ 19 ] reported that the herbal mixture contains tannins, saponins and flavonoids, and these plant chemicals are known to impact spermatogenesis. A typical example is tannins extracted from Z. officinale (a plant composition of the product) which have been reported to increase sperm parameters [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Udom,

Ise,

Aziakpono

et al. 2023

BioMedicine

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Introduction Dr Iguedo Goko Cleanser® is a herbal formulation (HF) widely marketed in southern Nigeria and purported to be very efficacious for the management of various diseases including giardiasis, toilet infections, hypertension, diabetes, ulcer, impotence, low libido, low sperm count amongst others. Medicinal plants reportedly produce an array of adverse reactions capable of inducing harmful conditions, including death. Aim This study evaluated the subchronic toxicity concern of HF on testicular function and gonadal histoarchitecture in Wistar rats. Methods Thirty Wistar rats of both sexes were randomly divided into six groups (5/group) and were orally administered HF for 60 days. The control groups received 5 mL/kg of distilled water; the treatment groups were administered 476.24 and 158.75 mg/kg body weight of HF each for both male and female rats. Using standard procedures, semen analysis was done for all male rats. Animals were anaesthetised and sacrificed on the 62nd day; the gonads were eviscerated, weighed and fixed in 10% buffered formalin for histopathological examinations. Results Significant (p < 0.05) increase in sperm count relative to control as well as spermatotoxic effects were observed in male rats. Histologically, the ovary presented some degrees of pathologies: cloggy appearing ovarian cortex with a display of a tumour-like cortical area, scantily displayed primordial follicles, haemorrhagic blood vessels, atretic secondary follicle, and eroding granulosa cells amongst others. Testicular histopathology showed abnormal seminiferous tubules’ histoarchitecture, degenerated spermatids, distorted spermatogenic cells’ orientation, and displaced spermatids into the luminal space. Conclusion Herbal drugs are usually regarded to be completely safe due to their natural sources, however, this study discovered exposure-related toxic effects of Dr Iguedo Goko Cleanser® on testicular function and gonadal histomorphology. The findings recommend extreme caution with chronic use and avoidance whenever possible.

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Section: Discussionmentioning

confidence: 99%

Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Udom,

Ise,

Aziakpono

et al. 2023

BioMedicine

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“…Study of the hematological variables like haemeglobin (Hb) concentration, Pack Cell Volume (PCV), Red Blood Cell (RBC) and White Blood Cell (WBC) count proffer useful information about the haematological toxicities [61]. Yagari at the dose levels of 250 and 500 mg/kg b.w produced no significant changes in the hematological parameters.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the Toxicological Profile of Yagari

Agatemor

Nwodo

2021

APRJ

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Background and Objective: Data from researches have shown a rise in disease, ill health and death linked with the utilization of herbal products, thereby raising global awareness in the last few years. On that account, the safety and toxicity evaluations of herbal products and preparations was essential. This study evaluated the toxicological profile of Yagari – a herbal mixture. Materials and Methods: Acute oral toxicity (LD50) was carried out in Swiss mice according to Lorke’s method while sub-chronic toxicity study was carried out with 20 adult albino rats which were divided into 4 groups of 5 animals each. Group one served as control and received normal saline while Groups 2 to 4 received 250, 500 and 1000 mg/kg yagari respectively for 28 days. The body weights of the rats were monitored while on day 29, the rats were sacrificed and blood samples and organs were collected for biochemical/hematological analysis and histopathological examination respectively. Results: Results showed that Yagari is not noxious up to 5000 mg/kg following acute oral toxicity study. The sub-chronic toxicity test divulged that Yagari had no serious end results on the biochemical, hematological and histopathological parameters, although the body weight of the animals significantly increased. Conclusion: It was concluded that Yagari is not toxic, still further investigations on a large number of animals are essentially needed to denote safety and efficacy of the herbal formulation.

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Haematological Study on the Effects of Goko Cleanser (Herbal Mixture) on Adult Female Wistar Rats

Cited by 2 publications

References 8 publications

Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats

Evaluation of the Toxicological Profile of Yagari

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