Haematological variations in visually anaemic sheep naturally infected with Haemonchus contortus in farm conditions at arid Rajasthan

Swarnkar, C.P.; Singh, D.

doi:10.56093/ijans.v88i1.79421

Cited by 5 publications

(2 citation statements)

References 23 publications

(17 reference statements)

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“…In the current investigation, a diseased sheep’s hemoglobin level was significantly lower than that of a healthy sheep (p ≤0.05). The current finding was consistent with previously reported results (Ved Prakash et al, 2010; Shekh I. J et al, 2017; Tiwari A.N. et al, 2017) .…”

Section: Resultssupporting

confidence: 94%

Role of IL-6 and IL10 immune response genes against nematodeHaemonchus contortusin ovis aries- a novel report

Rawat,

Pal,

Banerjee

et al. 2023

Preprint

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Haemonchus contortus is one of the most deadly parasites affecting sheep industry causing heavy economic loss. In our earlier study, we have reported RIGI, an earlier established antiviral molecule and CD14 (an earlier established antibacterial molecule) to have potential role in antiparasitic immunity for the first time. In this current study, we aim to clone and sequence the IL-6 and IL10 genes in sheep (Ovis aries) and utilized bioinformatics methods to analyze and compare the functional and structural domains of peptides produced from IL6 and IL10. Furthermore, the study explored these domains in three-dimensional structures. The findings of this study provide molecular characterization of IL-6 and IL10 in sheep, which is essential for advancing our understanding of functional immune responses in this animal. We report IL6 and IL10 to have potential antiparasitic role against H. contortus for first time. The production of these molecules opens up possibilities for its potential use as recombinant proteins to manipulate the immune response. Evaluating its value in vaccine research and gaining a broader understanding of its role in immune responses becomes feasible with the availability of IL-6 and IL10. Moreover, the differential mRNA expression levels of IL-6, IL10 between healthy and diseased sheep indicate its crucial role in maintaining homeostasis and mounting immune responses. IL10 acts as receptor for H. contortus. The identification of this immune-responsive gene also offers new avenues for investigating long-term resistance to H. contortus infection in sheep.

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Section: Resultssupporting

confidence: 94%

Role of IL-6 and IL10 immune response genes against nematodeHaemonchus contortusin ovis aries- a novel report

Rawat,

Pal,

Banerjee

et al. 2023

Preprint

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“…The sheep were treated several times with different classes of anthelmintics, but problem of haemonchosis remained uncontrolled. Study on anthelmintic resistance in H. contortus exhibited 0% and 25% efficacy for fenbendazole (FBZ) and levamisole (LEV), respectively on FECRT (Swarnkar et al 1999b).…”

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confidence: 99%

Worm control approaches and their impact on status of anthelmintic resistance at an organized sheep farm

Singh

Swarnkar

2017

Indian J of Anim Sci

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The aim of study was to ascertain efficiency of different worm management strategies in reversion to susceptibility to anthelmintics in sheep maintained at Sheep Breeding Farm, Fatehpur (Rajasthan). An increase in efficacy of benzimidazole (BZ) from nil to 14 and 75% was observed after 6 and 8 years of withdrawal, respectively. The restricted use of imidothiazoles enhanced efficacy from 25% in 1998 to 92% in 2007. From 2010, community dilution strategies through introduction of newly purchased sheep were implemented and evaluated for their impact on reversion to susceptibility after 5 years. A marginal increase in BZ efficacy (up to 43%) was observed after introduction of new animals possessing anthelmintic resistant/susceptible worms and rotational use of anthelmintic types. A moderate rise in BZ efficacy (up to 56%) was observed on community dilution through introduction of Nali sheep possessing susceptible Haemonchus contortus and use of BZs and closantel in rotation. A significant increase in BZ efficacy (up to 88%) was noticed on community dilution through introduction of Marwari sheep possessing susceptible H. contortus and application of targeted selective treatment (TST) using closantel. The efficacy of tetramisole (TEM) increased from 25% (1998) to 92% (2007) after 8 years of withdrawal TEM which further increases to 99% (2015) after introduction of TEM susceptible H. contortus through newer sheep coupled with rotation of anthelmintic classes. The results indicated that just withdrawal of ineffective anthelmintic is not sufficient enough to cause evident reversion to susceptibility. However, community dilution coupled with TST with newer class of anthelmintic will help in reversion to susceptibility in gastrointestinal nematodes at faster rate in sheep.

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Ovine haemonchosis: a review

Naeem

Zahid²,

Roohi

2020

Trop Anim Health Prod

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Sheep farming is the backbone of a rural economy in developing countries, and haemonchosis is a major impediment in the way of its progress. Haemonchus contortus (H. contortus) infection persists all over the world particularly in the tropical and subtropical regions. Various review articles have been published to substantially cover one or more aspects of its morphology, prevalence, pathogenesis, symptoms, diagnosis, immune response, drug resistance, treatment, and control measure. The objective of this paper is to briefly review past and present information available in the aforementioned areas in one place to enable the readers to fully understand the problem from a broader perspective. H. contortus parasite harbours in abomasum of affected animal and feeds on its blood, producing mild to severe symptoms and even death in acute form. The parasite thus inflicts heavy production losses and is of economic importance. H. contortus has developed diverse characters over the years leading to limited success in the production of vaccines. Indiscriminate use of the anthelmintics has produced drug resistance against almost all conventional products. Efficacy of medicinal plants and non-conventional chemicals has been reported under controlled experiments; however, research on their adverse effects on growth and fertility is yet to be studied. Research on molecular tools for identification and introduction of resistant genes into the flock is also underway but still a long journey to find its field application. Crossbreeding may compromise the production traits of the existing flock. In given circumstances, a targeted selective treatment approach along with selective breeding, culling of more susceptible animals, and maintaining a good body condition score through the provision of a balanced diet remains a workable strategy to control haemonchosis in sheep.

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Haematological variations in visually anaemic sheep naturally infected with Haemonchus contortus in farm conditions at arid Rajasthan

Cited by 5 publications

References 23 publications

Role of IL-6 and IL10 immune response genes against nematodeHaemonchus contortusin ovis aries- a novel report

Role of IL-6 and IL10 immune response genes against nematodeHaemonchus contortusin ovis aries- a novel report

Worm control approaches and their impact on status of anthelmintic resistance at an organized sheep farm

Ovine haemonchosis: a review

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