Haemolytic disease of the newborn due to anti‐Ce

Abstract

A baby was readmitted to the hospital 3 days after delivery when she developed jaundice. At admission, the direct antiglobulin test was also found to be positive. The baby required emergency exchange transfusion. A strongly reacting IgG anti-Ce (Rh7) was found in the serum of the mother. Severe haemolytic disease of the newborn due to anti-Ce is very rare. The mother's serum had been screened and found negative for red cell antibodies at 16 weeks gestation but the test was not repeated later in pregnancy when this antibody might have been detected.

Alloimmunisation during pregnancy in Greece: need for nationwide HDFN prevention programme

“…Fortunately, in our case there were no signs of HDFN in none of the two neonates delivered by Caesarean section at 36 weeks of gestation. It is worth mentioning that anti‐Ce cases could be misidentified as anti‐C and hence underreported (Malde et al ., ; Ranasinghe et al ., ).…”

Anti‐Ce complicating two consecutive pregnancies with increasing severity of haemolytic disease of the newborn

“…Although the Ce antigen (RH7) is absent in 32% of white Caucasians (Reid & Lomas‐Francis, 1997), HDN because of anti‐Ce is rare. Only two cases of severe HDN requiring exchange transfusions have been reported previously (Malde et al ., 2000; Wagner et al ., 2000). We have described a woman with anti‐Ce who had two consecutive pregnancies with increasing severity of haemolytic disease (HD).…”

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The Ce antigen is expressed on red cells of individuals with Rh haplotypes, R 1 or CDe and r H or Cde. However, anti-Ce is rare, and only two cases of severe haemolytic disease of the newborn (HDN) caused by this antibody have been described (Malde et al, 2000;Wagner et al, 2000). We describe a woman who was found to have anti-Ce in her second pregnancy, resulting in a neonate with HDN that required exchange transfusion.

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