Haemoperitoneum in von Willebrand's Disease

Sharp, A. A.; Ellis, H. A.

doi:10.1136/bmj.2.5195.356

Cited by 6 publications

(1 citation statement)

References 7 publications

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“…This suggests the presence of a capillary abnormality as well as thrombocytopenia, and it seems possible that this family may represent another variant of the von Wille brand syndrome. Thrombocytopenia has occasionally been reported in association with this condition (Estren et alii, 1946;Sharp and Ellis, 1960). Hicks and Pitney (1957) found that normal plasmas gave a rather wide range of minimum substrate clotting times in the thromboplastin generation screening test.…”

Section: Discussionmentioning

confidence: 99%

Hereditary Bleeding Disorders in Western Australia

1964

Australasian Annals of Medicine

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Summary The clinical and laboratory findings are reviewed in 147 cases of hereditary bleeding disorders investigated in the years 1956 to 1963. There was an unexpectedly large number of hæmophiliacs (55) in the series, many of whom were very mildly affected. The importance of mild hæmophilia as a cause of unexpected surgical bleeding is noted. The findings in patients with von Willebrand's syndrome were very variable, and about a third had a formal bleeding time when first investigated. The difficulty in diagnosis and distinction from mild hæmophilia is discussed. Menorrhagia was found to be a very frequent presenting symptom in females with this condition. A family affected by hereditary thrombocytopenia is described. This was considered to be a variant of the von Willebrand syndrome. The Hicks‐Pitney test was evaluated and found to be reliable as a screening procedure in patients with less than 30% antihæmophilic globulin.

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Section: Discussionmentioning

confidence: 99%

Hereditary Bleeding Disorders in Western Australia

1964

Australasian Annals of Medicine

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von Willebrand disease associated with familial thrombocytopenia and increased ristocetin‐induced platelet aggregation

et al. 1981

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Two cases of von Willebrand disease (vWD) associated with familial thrombocytopenia were reported. The proband (daughter) and her father showed thrombocytopenia with large platelets and decreased von Willebrand factor activity (VIIIR:WF). Factor VIII procoagulant activity (VIII:C) and factor VIII-related antigen (VIIIR:AG) were normal, but both patients revealed an increased ristocetin-induced platelet aggregation and a qualitative abnormality of the factor VIII protein, which was characterized by fast electrophoretic mobility of VIIIR:AG and an abnormal elution of factor VIII-related activities on Sepharose 2B. DDAVP was hemostatically effective even in this thrombocytopenic patient undergoing a dental extraction.

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von Willebrand's Disease in Gynecologic and Obstetric Practice

Pugh¹

1972

International Journal of Gynecology & Obstetrics

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Haemoperitoneum in von Willebrand's Disease

Cited by 6 publications

References 7 publications

Hereditary Bleeding Disorders in Western Australia

Hereditary Bleeding Disorders in Western Australia

von Willebrand disease associated with familial thrombocytopenia and increased ristocetin‐induced platelet aggregation

von Willebrand's Disease in Gynecologic and Obstetric Practice

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