Haemorheological, platelet and endothelial factors in essential hypertension

Lee, A J

doi:10.1038/sj.jhh.1001456

Cited by 12 publications

(8 citation statements)

References 5 publications

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“…Association with hypertension was also studied in 547 hypertensives enrolled in a clinical trial and in 624 normotensives drawn from the Stanislas Cohort. In the "blood pressure study," parents with the 353Gln or Ϫ323Ins allele had lower blood pressures than did noncarriers at each examination, independent of covariates (0 [1][2][3][4] and blood pressure (BP) and/or hypertension have been described. Association studies cannot establish whether abnormalities of rheology and coagulation occur as a consequence of the higher BP or whether these could be factors that contribute to high BP.…”

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confidence: 99%

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Association Between Factor VII Polymorphisms and Blood Pressure

Sass

Blanquart²,

Morange³

et al. 2004

Hypertension

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Abstract-The purpose this study was to determine whether Arg353Gln and Ϫ323Del/Ins polymorphisms of factor VII (FVII) are related to blood pressure levels and hypertension. Subjects were drawn from the Stanislas Cohort, a longitudinal, familial French cohort examined twice since 1994. The "blood pressure study" included 1342 subjects free of medication use that could affect blood pressure. The "hypertension study" included 645 normotensive and 77 hypertensive adult subjects. Association with hypertension was also studied in 547 hypertensives enrolled in a clinical trial and in 624 normotensives drawn from the Stanislas Cohort. In the "blood pressure study," parents with the 353Gln or Ϫ323Ins allele had lower blood pressures than did noncarriers at each examination, independent of covariates (0 [1][2][3][4] and blood pressure (BP) and/or hypertension have been described. Association studies cannot establish whether abnormalities of rheology and coagulation occur as a consequence of the higher BP or whether these could be factors that contribute to high BP. However, data suggest that hemorheologic factors may be implicated in BP homeostasis. Thrombin, in addition to converting fibrinogen to fibrin, can interact with cell-surface receptors and induce several intracellular pathways. 5,6 Proangiogenic activities of thrombin have been described, 5 and thrombin can also modulate vascular tone 7 and have proinflammatory properties. 8 All of these factors can play a role in initiating and maintaining an elevation in BP.Factor VII (FVII) is a key factor in the coagulation cascade leading to the production of thrombin. FVII also elicits several cellular responses, such as angiogenesis 9 -11 and inflammation, 12,13 that may be related to hypertension, and associations between FVII and BP have been found. 14 -16 Genetic variations in the FVII gene, the Arg353Gln and the Ϫ323Del/Ins polymorphisms, have been related to FVII levels and coagulant activity. [17][18][19][20] An association between BP and the Arg353Gln polymorphism was described in a genetic isolate. 21 Therefore, the purpose of this study was to investigate the association of these 2 polymorphisms with BP levels and hypertension in a large, family-based population. Methods BP StudyThe study population was selected from the Stanislas Cohort 22 For the present study, 1342 individuals (657 men and 686 women from 424 families) were selected on the basis of the following criteria: (1) subjects were present at both the first (T0) and second (Tϩ5) examinations; (2) data from both examinations and information on FVII Arg353Gln and Ϫ323Del/Ins genotypes were available; and (3) at each visit, there was no indication of antihypertensive, lipidlowering, or anti-inflammatory drug use. Hypertension Studies Sample Group 1The normotensive subjects were drawn from the "blood pressure levels study" sample population. There were 295 fathers and 350 mothers with a systolic blood pressure (SBP)/diastolic blood pres-

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confidence: 99%

“…A ssociations between rheologic and hemostatic factors [1][2][3][4] and blood pressure (BP) and/or hypertension have been described. Association studies cannot establish whether abnormalities of rheology and coagulation occur as a consequence of the higher BP or whether these could be factors that contribute to high BP.…”

mentioning

confidence: 99%

Association Between Factor VII Polymorphisms and Blood Pressure

Sass

Blanquart²,

Morange³

et al. 2004

Hypertension

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“…A final point leading to difficulty is that hypertension can be associated with an increased risk of thrombosis independently of the endothelium, i.e. raised fibrinogen, a molecule produced mainly by the liver, and abnormalities in blood platelets [22][23]. This illustrates the complexity of vascular biology and medicine.…”

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confidence: 99%

How a Damaged Blood Vessel Wall Contibutes to Thrombosis and Hypertenasion

Blann¹

2003

Pathophysiol Haemos Thromb

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“…▂ Ferner kann es zur Interaktion zwischen koronarer Makro-und Mikrostrombahn beim Hypertoniker kommen [33]. ▂ Diese vaskulären Veränderungen können durch Störungen der Hämos-tase aggraviert werden [38,44].…”

Section: Pathophysiologieunclassified

Hochdruckherz und hypertensive Mikroangiopathie

Kelm

Strauer

2003

Der Internist

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Cardiac alterations in patients with arterial hypertension comprise the manifestation of stenosis in epicardial arteries, disease of coronary resistive vessels, prothrombotic changes and endothelial dysfunction, pronounced perivascular and interstitial fibrosis, left ventricular hypertrophy, dilatation of the left atrium, increased sympathetic drive and degeneration of aortic valve. These alterations leads to the major clinical manifestations of hypertensive heart disease, that are symptoms of reduced coronary conductance, left ventricular hypertrophy, diastolic and systolic dysfunction with or without left ventricular enlargement and arrhythmia. Different non-invasive and invase procedures are available for screening and follow up of patients with hypertensive heart disease. The primary therapeutic target is, apart from lowering blood pressure, to reverse cardiac manifestations of arterial hypertension using specific therapeutic algorithms.

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Haemorheological, platelet and endothelial factors in essential hypertension

Cited by 12 publications

References 5 publications

Association Between Factor VII Polymorphisms and Blood Pressure

Association Between Factor VII Polymorphisms and Blood Pressure

How a Damaged Blood Vessel Wall Contibutes to Thrombosis and Hypertenasion

Hochdruckherz und hypertensive Mikroangiopathie

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