Haemostatic Activation before and after Surgery in Patients with and without Gastric Malignancy

Hb, Rahr; Jv, Sørensen; Jf, Larsen; Fs, Jensen; C, Bredahl; Nieuwenhuizen, W.

doi:10.1055/s-0038-1642510

Cited by 20 publications

(9 citation statements)

References 9 publications

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“…A significant increase of all clotting markers during the postoperative period compared with preoperative levels was observed, showing a similar degree of clotting activation in both groups of patients. Our results confirm that a significant activation of the coagulation system takes place after surgery [27]. It has also been suggested that the increase in these clotting markers may be predictive for the development of postoperative thrombosis, thus being useful in the detection of a prethrombotic state after surgery [281.…”

Section: Discussionsupporting

confidence: 76%

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery

López¹,

*²,

Pardo³

et al. 1998

International Journal of Clinical & Laboratory Research

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Without prophylaxis, patients subjected to major abdominal surgery have a risk of deep vein thrombosis of approximately 30%, while the rate varies between 40% and 60% in orthopedic surgery. The reasons for this discrepancy are not completely understood. The present study was designed to compare the pre-and postoperative behavior of different coagulation and fibrinolysis parameters in patients undergoing both types of surgery, receiving low molecular weight heparin prophylaxis. Samples were taken before operation and on postoperative days 1,3, and 7. The following parameters were assessed: prothrombin fragment 1+2, thrombin-antithrombin III complexes, fibrinopeptide A, tissue plasminogen activator, plasminogen activator inhibitor, plasmin-c~__-antiplasmin complexes, and fibrin degradation products. We found a significant increase in the clotting markers postoperatively compared with preoperative values (P<0.05), both in abdominal and orthopedic surgery, indicating a marked hemostatic activation which remained until postoperative day 7. A significant increase in plasminogen activator inhibitor (P<0.01) and a decrease in tissue plasminogen activator and plasmin-%-antiplasmin complexes was also observed early

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Section: Discussionsupporting

confidence: 76%

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery

López¹,

*²,

Pardo³

et al. 1998

International Journal of Clinical & Laboratory Research

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“…Serum peptidome analyses by either matrix‐assisted laser‐desorption ionization or surface‐enhanced laser‐desorption ionization time‐of‐flight mass spectrometry revealed FpA peptide as a m/z peak at around 1469 Da particularly upregulated in metastatic GC or in GC with lymph node metastasis, as well as in patients at high risk for GC . Previous laboratory assays showed that FpA levels increased with the extent of primary tumor in postoperative patients with malignant disease since its early stages …”

Section: Coagulation‐related Proteins and Cancermentioning

confidence: 99%

Coagulation and fibrinolysis in gastric cancer

Repetto

2017

Annals of the New York Academy of Sciences

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Coagulation is a highly conserved process occurring after an injury to a blood vessel and resulting in hemostasis. In the thrombus microenvironment, finely orchestrated events restore vessel integrity through platelet activation, adhesion, and aggregation (primary hemostasis), followed by the coagulation cascades, thrombin generation, and fibrin clot deposition (secondary hemostasis). Several studies on cancer have provided insight into dramatic changes to coagulation-related events (i.e., fibrin clot deposition, fibrinolysis) during tumor pathogenesis, progression, and metastasis, in addition to a tumor-driven systemic activation of hemostasis and thrombosis (Trousseau's syndrome). Diverse molecular and cellular effectors participate in the cross talk between hemostasis and tumors. Here, we focus on some aspects of the interconnection between cancer biology and hemostatic components, with particular attention to some key coagulation-related proteins (e.g., tissue factor, thrombin, fibrinogen, and D-dimers) in the particular case of gastric cancer (GC). Recent advances in deciphering the complex molecular link between GC and the coagulation system are described, showing their important roles in better management of patients affected by GC.

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“…The decrease in inhibitor levels during the postoperative period would seem compatible with the well-known simultaneous increase in markers of hemostatic activation (whether due to consumption or lack of inhibition). We have previously reported levels of such mark ers in the same patients [5]. The cancer pa tients had higher levels of fibrinopeptide A and fibrin degradation products on day 0 and day 7, whereas levels of prothrombin frag ment 1+2, thrombin-AT complex and soluble fibrin did not differ on any of the days.…”

Section: Discussionmentioning

confidence: 88%

“…Two age-matched subgroups of a previously de scribed patient group were investigated [5]. In brief, 4 1 patients undergoing elective gastric surgery for either benign or malignant disorders were included after written informed consent.…”

Section: Patientsmentioning

confidence: 99%

Determination of Coagulation Inhibitor Levels and Resistance to Activated Protein C in Patients Undergoing Gastric Surgery for Benign and Malignant Disorders

Andersen

Rahr

Sørensen³

1997

Pathophysiol Haemos Thromb

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The aim of the present study was to determine plasma levels of protein C antigen (PC:Ag) and activity (PC:Act), tissue factor pathway inhibitor (TFPI), protein S (PS), antithrombin (AT), heparin cofactor II (HCII), and resistance to activated protein C (APCR) before, during and after elective gastric surgery in order to compare patients with and without gastric malignancy. Blood was collected from a forearm vein of two age-matched patient groups undergoing elective gastric surgery, 9 patients with and 9 patients without gastric malignancy. The plasma levels of the parameters were determined preopera-tively, intraoperatively, and on days 1 and 7 postoperatively. On the 1st and 7th postoperative day, plasma levels of HCII were significantly lower in patients operated for gastric malignancy than in those operated for benign disorders, but levels of TFPI, PC:Act, PC:Ag, AT, PS and APCR did not differ in the postoperative period. The day-to-day variation was also rather similar in the two patient groups.

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Haemostatic Activation before and after Surgery in Patients with and without Gastric Malignancy

Cited by 20 publications

References 9 publications

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery

Hemostatic markers in surgery: a different fibrinolytic activity may be of pathophysiological significance in orthopedic versus abdominal surgery

Coagulation and fibrinolysis in gastric cancer

Determination of Coagulation Inhibitor Levels and Resistance to Activated Protein C in Patients Undergoing Gastric Surgery for Benign and Malignant Disorders

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