Haff Disease: From the Baltic Sea to the U.S. Shore

Buchholz, Udo; Mouzin, Eric; Dickey, Robert; Moolenaar, Ron; Sass, Neil; Mascola, Laurene

doi:10.3201/eid0602.000215

Cited by 65 publications

(62 citation statements)

References 6 publications

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“…In this study, the symptoms of five GIG-treated mice were similar to the symptoms in rhabdomyolysis, especially three of them (20110618-G0.5-No.2, 20110618-G0.5-No.6, and 20110618-G4.0-No.4). Research has shown that most patients mainly have diffuse myalgia and chest pain, and those with mild symptoms recovered quickly within 2-3 days [1,2]. This was the same phenomenon that appeared in our experiment.…”

Section: Discussionsupporting

confidence: 88%

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Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

et al. 2015

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Section: Discussionsupporting

confidence: 88%

“…CK is an experimental indicator used for defining rhabdomyolysis when it is 5 times more than the normal value [1]. Numerous reports have described that ALT, AST, and LDH would increase more than fivefold when someone has suffered from rhabdomyolysis [14][15][16].…”

Section: Discussionmentioning

confidence: 99%

Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

et al. 2015

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“…Outbreaks resembling Haff disease were reported in Sweden and Soviet Union from 1934 to 1984 (2). To date only 23 cases have been reported in U.S. literature (2,3). Cases in the U.S. have been associated with consumption of Buffalo fish, crawfish or salmon (3).…”

Section: Introductionmentioning

confidence: 99%

“…Most patients survived without sequelae but a few died quickly. Outbreaks resembling Haff disease were reported in Sweden and Soviet Union from 1934 to 1984 (2). To date only 23 cases have been reported in U.S. literature (2,3).…”

Section: Introductionmentioning

confidence: 99%

Haff Disease after Eating Crayfish in East China

Zhang

Yang

et al. 2012

Intern. Med.

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Haff disease, first identified in Europe, is unexplained rhabdomyolysis in a person who ingested fish within the 24 hours before onset of illness. Cases of Haff disease after the consumption of fresh water fish have never been reported in China but have been frequently reported from the Baltic region. We first describe five cases of muscle weakness and rhabdomyolysis that occurred after eating crayfish in China and discuss the different epidemiologic and etiologic aspects of this disease.

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“…In the disease, no nervous abnormality, fever, megalosplenia, and hepatomegalia were observed in the patients, many of whom stayed alive with no aftereffect, but some were dead. Cases of Haff disease have been known in Sweden, Russia (former Soviet Union), USA, and Brazil since it was first recognized at Haff beach on the coast of the Baltic Sea in 1924 (Buchholz et al 2000;dos Santos et al 2009;Lahgley and Bobbitt 2007;Zu jeddeloh 1939). Although Haff disease is similar to PLTX-like toxin poisoning in terms that it is caused by ingesting specific fish, and that the main symptom is rhabdomyolysis, the relationship between both diseases remains to be elucidated.…”

Section: -4 Haff Diseasementioning

confidence: 99%

Toxins of Pufferfish—Distribution, Accumulation　Mechanism, and Physiologic Functions

Arakawa¹,

Takatani²,

Taniyama³

et al. 2017

Aqua-BioSci. Monogr. (ABSM)

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Keywordsunit) is defined as the amount of toxin required to kill a 20-g male mouse within 30 min after intraperitoneal administration], and the minimum lethal dose (MLD) for humans is estimated to be approximately 10000 MU (ª2 mg) (Noguchi and Ebesu 2001).The main symptoms of human intoxication include numbness of lips, tongue and the limbs, paresthesia, dysarthria, respiratory distress, and death is caused by respiratory failure in the most critical cases (Noguchi and Ebesu 2001). According to Toda et al. (2012), 651 incidents of TTX poisoning due to pufferfish have occurred in Japan, involving 976 patients and 56 deaths during the 22 years from 1989 to 2010. Many cases occurred during the winter season in coastal prefectures of the Seto Inland Sea, with "komonfugu" Takifugu poecilonotus, "mafugu" Takifugu porphyreus, "higanfugu" Takifugu pardalis, "shosaifugu" Takifugu Abstract Our many years of studies have provided a lot of information regarding distribution, accumulation mechanism, and physiologic functions of the natural toxins harbored by pufferfish. We detected tetrodotoxin (TTX) and/or its derivatives in several species of aquatic organisms including marine bacteria. This, along with the fact that pufferfish became non-toxic when they were reared with non-toxic feed, indicated that the toxification of pufferfish is of exogenous origin. Subsequently, we revealed by various TTX administration experiments using non-toxic cultured pufferfish that the TTX administered into the muscle or digestive tract rapidly transferred to the liver and skin, and that the toxin transfer to the gonads was largely different between male and female, suggesting the involvement of maturation in the internal kinetics of TTX. On the other hand, we visualized micro-distribution of TTX in the tissues of various TTX-bearing organisms using an immunohistochemical technique, giving a crucial insight to elucidate physiologic functions of TTX including the function as a defensive or offensive agent. Furthermore, we found that Southeast Asian freshwater pufferfish possess paralytic shellfish poison (PSP) as a main toxin, and that boxfish and Bangladeshi freshwater pufferfish bear a palytoxin (PLTX)-like toxin, and cause a rhabdomyolysis, which overturned the common sense that pufferfish toxin equals TTX.

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Haff Disease: From the Baltic Sea to the U.S. Shore

Cited by 65 publications

References 6 publications

Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

Haff Disease after Eating Crayfish in East China

Toxins of Pufferfish—Distribution, Accumulation　Mechanism, and Physiologic Functions

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Haff Disease: From the Baltic Sea to the U.S. Shore

Cited by 65 publications

References 6 publications

Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

Investigation of the hazardous substance causing crayfish-induced rhabdomyolysis via a mouse model, a hemolysis assay, and a cytotoxicity assay

Haff Disease after Eating Crayfish in East China

Toxins of Pufferfish—Distribution, Accumulation Mechanism, and Physiologic Functions

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Product

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Toxins of Pufferfish—Distribution, Accumulation　Mechanism, and Physiologic Functions