Hailey–Hailey disease with a novel variant, c.1978dupG, in the
            <i>ATP2C1</i>
            gene

Itsukage, Shizu; Kambe, Naotomo; Ueki, Yoko; Sato, Chika; Nakano, Hajime

doi:10.1111/ced.14306

Clin Exp Dermatol

2020

DOI: 10.1111/ced.14306

|View full text |Cite

Hailey–Hailey disease with a novel variant, c.1978dupG, in the ATP2C1 gene

Shizu Itsukage

Naotomo Kambe

Yoko Ueki

et al.

Abstract: Gold L et al. Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: two phase 3 randomized clinical trials.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Other1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Inherited Acantholytic Disorders

Zamiri

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

Darier disease (DD) and Hailey–Hailey disease (HHD) are autosomal dominant disorders characterised by epidermal acantholysis. They have a similar molecular pathogenesis, with mutations in intracellular calcium pumps of the endoplasmic reticulum ( SERCA2 ) and Golgi ( SPCA1 ), respectively. DD presents with persistent, hyperkeratotic papules in a seborrhoeic distribution, associated with nail changes and palmar pitting. HHD presents with painful, mainly flexural, erosions. In both, secondary infection is common and hypertrophic flexural disease can be disabling. Histologically, both are characterised by loss of epidermal intercellular adhesion (acantholysis). DD may be accompanied by neuropsychiatric symptoms such as depression, epilepsy, learning disabilities or bipolar disease. First line topical treatment is with emollients, antimicrobials and corticosteroids. Oral antibiotics are often necessary for exacerbations; other systemic options include retinoids and ciclosporin. Physical measures such as laser resurfacing, photodynamic therapy, botulinum toxin and surgical interventions can be considered in refractory cases.

show abstract

Inherited Acantholytic Disorders

Zamiri

2024

Rook's Textbook of Dermatology

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Hailey–Hailey disease with a novel variant, c.1978dupG, in the ATP2C1 gene

Abstract: Gold L et al. Efficacy and safety of topical clascoterone cream, 1%, for treatment in patients with facial acne: two phase 3 randomized clinical trials.

Cited by 1 publication

References 5 publications

Inherited Acantholytic Disorders

Inherited Acantholytic Disorders

Contact Info

Product

Resources

About