Half-sandwich Iridium(III) complexes with triphenylamine-substituted dipyridine frameworks and bioactivity applications

He, Xiangdong; Liu, Xicheng; Tang, Yanhua; Du, Jiuyao; Tian, Meng; Xu, Zhishan; Liu, Zhe

doi:10.1016/j.dyepig.2018.08.006

Cited by 30 publications

(21 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this work, a series of half‐sandwich Ru II complexes were obtained in accordance with the methods of literature (Scheme ) . The N^N chelating ligands L1 and L2 were prepared by Suzuki coupling reaction (4‐bromobipyridine and the corresponding TPA boric acids), L3 and L4 were obtained by Wittig reaction (4′‐methyl‐(2,2′‐bipyridine)‐4‐carbaldehyde and the corresponding Wittig reagents).…”

Section: Resultsmentioning

confidence: 99%

“…The study showed that TPA‐appended phenanthroline chelating ligand (N^N) applied to cycloiridium complex and acted as an effective phototherapy drug towards HeLa cells, which can effectively induce the production of singlet oxygen ( 1 O 2 ) after 730 nm laser irradiation and lead to apoptosis . Our group also reported a series of metal iridium complexes with TPA‐substituted dipyridine frameworks, which provides additional stability for complexes, and even adjust the lipid solubility, so as to regulate the anticancer activity . The excellent characteristics of TPA‐appended metal iridium complexes stimulate us to investigate the applications of other transition‐metal complexes .…”

Section: Introductionmentioning

confidence: 99%

“…The excellent characteristics of TPA‐appended metal iridium complexes stimulate us to investigate the applications of other transition‐metal complexes . Above all, four half‐sandwich Ru II complexes (Scheme ) were synthesized by the introduction of TPA and its derivatives to bipyridine chelating ligand through a single or double bond . Anticancer activities of target complexes were obtained by MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide) assay toward A549 (lung cancer), HeLa (cervical cancer) and HepG2 (hepatoma) cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Half‐sandwich Ruthenium (II) complexes with triphenylamine modified dipyridine skeleton and application in biology/luminescence imaging

Ge¹,

Liu²,

Tian³

et al. 2019

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

Four half-sandwich ruthenium II (Ru II ) complexes with triphenylaminemodifed dipyridine frameworks were synthesized and characterized. The cytotoxicity of target complexes toward A549 (lung cancer cells), HeLa (cervical cancer cells) and HepG2 (hepatoma cells) were obtained by the MTT assay, which were superior to cisplatin with the IC 50 values changed from 2.4 ± 0.1 μM to 9.2 ± 2.7 μM. Meanwhile, complexes possess the ability of antimetastasis to cancer cells. Ru II complexes could be transported by serum albumin, catalyze the conversion of NADH (the reduced state of nicotinamide-adenine dinucleotide) to NAD + and induce the accumulation of reactive oxygen species, which confirmed the antineoplastic mechanism of oxidation. Ru II complexes could enter A549 cells followed by a non-energy dependent cellular uptake mechanism, target lysosomes with the Pearson's colocalization coefficient of 0.75, lead to lysosomal damage, disturb the cell cycle (S phase), and eventually induce apoptosis. The results demonstrate that these Ru II complexes are potential anticancer agents with dual functions, including metastasis inhibition and lysosomal damage.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Half‐sandwich Ruthenium (II) complexes with triphenylamine modified dipyridine skeleton and application in biology/luminescence imaging

Ge¹,

Liu²,

Tian³

et al. 2019

Applied Organom Chemis

Self Cite

View full text Add to dashboard Cite

show abstract

“…The most recent works about lysosomal imaging have been reported in the literature by which Ir (III) complexes have been successfully applied for the said purpose …”

Section: Compartmentalization and Staining Of Cellsmentioning

confidence: 99%

Cyclometalated Iridium (III) complexes: Recent advances in phosphorescence bioimaging and sensing applications

Abbas

Din

Raheel

et al. 2019

Applied Organom Chemis

View full text Add to dashboard Cite

The phosphorescence bioimaging and sensing applications of Iridium (III) complexes, in particular to subcellular organelle staining as well as sensing of biologically important analytes, have been reviewed here. The bioimaging applications of the metal complexes provide an attractive alternative to fluorescent organic compounds in the construction of biosensors and biolabels because of having certain advantages.

show abstract

“…The anticancer activity of a simple half-sandwich Ir III complex increases nearly 10 times when the bipyridine chelating ligand (N ∧ N) is replaced by a phenyl pyridine ligand (C ∧ N) (Liu and Sadler, 2014). The IC 50 value (the concentration at which the growth of 50% of the cells is inhibited) of Ir III complex can be reduced by nearly 100 times by controlling the binding mode of bipyridine chelate ligand substituents and the number of triphenylamine (TPA) units (He et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Imidazole and Benzimidazole Modified Half-Sandwich IridiumIIIN-Heterocyclic Carbene Complexes: Synthesis, Anticancer Application, and Organelle Targeting

Liu

Han

et al. 2020

Front. Chem.

Self Cite

View full text Add to dashboard Cite

Herein, we report the synthesis, characterization and anticancer activity of a series of half-sandwich iridium III imidazole and benzimidazole N-heterocyclic carbene (NHC) anticancer complexes, and the general formula of which can be expressed as [(η 5 -Cp x )Ir(C ∧ N)Cl]Cl (Cp x : pentamethylcyclopentadienyl (Cp * ) or biphenyl derivatives (Cp xbiph ); C ∧ N: imidazole and benzimidazole NHC chelating ligands). Compared with cis-platin, these complexes showed interesting antitumor activity against A549 cells. Complexes could bind to bovine serum albumin (BSA) by means of static quenching mode, catalyze the oxidation of nicotinamide adenine dinucleotide (NADH) and increase the levels of reactive oxygen species (ROS). Meanwhile, these complexes could arrest the cell cycles of A549 cells and influence the mitochondrial membrane potential significantly. Due to the inherent luminescence property, laser confocal test show that complexes could enter cells followed an energy-dependent mechanism and effectively accumulate in lysosome (the value of Pearson's co-localization coefficient is 0.70 after 1 h), further destroy lysosome integrity and induce apoptosis.

show abstract

Half-sandwich Iridium(III) complexes with triphenylamine-substituted dipyridine frameworks and bioactivity applications

Cited by 30 publications

References 48 publications

Half‐sandwich Ruthenium (II) complexes with triphenylamine modified dipyridine skeleton and application in biology/luminescence imaging

Half‐sandwich Ruthenium (II) complexes with triphenylamine modified dipyridine skeleton and application in biology/luminescence imaging

Cyclometalated Iridium (III) complexes: Recent advances in phosphorescence bioimaging and sensing applications

Imidazole and Benzimidazole Modified Half-Sandwich IridiumIIIN-Heterocyclic Carbene Complexes: Synthesis, Anticancer Application, and Organelle Targeting

Contact Info

Product

Resources

About