Hallucination Research: Into the Future, and Beyond

Jardri, Renaud; Larøi, Frank; Waters, Flavie

doi:10.1093/schbul/sby170

Cited by 11 publications

(12 citation statements)

References 11 publications

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“…To conclude, in line with the recommendations of the 2017 International Consortium on Hallucination Research, 101 this review shows the need to carry out a systematic investigation of MMHs. Overall, the evidence of the high prevalence and adverse prognostic outcomes of MMHs across disorders highlights the need to develop better assessment tools and theoretical models to systematically investigate these experiences and inform treatment strategies alongside the help of service users who experience MMHs and unimodal hallucinations.…”

Section: Unanswered Questions and Recommendationssupporting

confidence: 66%

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Montagnese

Leptourgos

Fernyhough

et al. 2020

Schizophrenia Bulletin

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Hallucinations can occur in different sensory modalities, both simultaneously and serially in time. They have typically been studied in clinical populations as phenomena occurring in a single sensory modality. Hallucinatory experiences occurring in multiple sensory systems—multimodal hallucinations (MMHs)—are more prevalent than previously thought and may have greater adverse impact than unimodal ones, but they remain relatively underresearched. Here, we review and discuss: (1) the definition and categorization of both serial and simultaneous MMHs, (2) available assessment tools and how they can be improved, and (3) the explanatory power that current hallucination theories have for MMHs. Overall, we suggest that current models need to be updated or developed to account for MMHs and to inform research into the underlying processes of such hallucinatory phenomena. We make recommendations for future research and for clinical practice, including the need for service user involvement and for better assessment tools that can reliably measure MMHs and distinguish them from other related phenomena.

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Section: Unanswered Questions and Recommendationssupporting

confidence: 66%

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Montagnese

Leptourgos

Fernyhough

et al. 2020

Schizophrenia Bulletin

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“…At the 2018 annual ICHR meeting, it was proposed that the pathological characteristics of and potential treatments for AVHs should be explored at molecular, synaptic, and neurotransmitter levels. 6 Accordingly, the pursuits of 'Understanding AVHs in healthy and psychotic individuals: Features, imaging, and interventions' (see Figure 1), 9 and 'Auditory verbal hallucinations and the auditory network: from molecules to connectivity' (see Figure 2), 10 have emerged as urgent problems to be solved going forward. Empirical clarification of pathological AVH subtypes may help prevent misdiagnosis and improper treatment planning in patients with AVHs, and thus, ultimately, may help clinicians to target treatment according to AVH subtype.…”

Section: Introductionmentioning

confidence: 99%

“… 6 Meanwhile, the application of linear support vector machines to functional magnetic resonance imaging (fMRI) data has enabled researchers to commence delineating AVH characteristics, including white matter connectivity alterations, in patients with schizophrenia, and neuroimaging studies of AVHs have since expanded rapidly worldwide. 6 – 8 …”

Section: Introductionmentioning

confidence: 99%

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Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review

Yu¹,

Wang

et al. 2020

J Int Med Res

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Objective To explore concomitant neuroimaging and genetic alterations in patients with schizophrenia with or without auditory verbal hallucinations (AVHs), and to discuss the use of pattern recognition techniques in the development of an objective index that may improve diagnostic accuracy and treatment outcomes for schizophrenia. Methods The pilot study included patients with schizophrenia with AVHs (SCH-AVH group) and without AVHs (SCH-no AVH group). High throughput sequencing (HTS) was performed to explore RNA networks. Global functional connectivity density (gFCD) analysis was performed to assess functional connectivity (FC) alterations of the default mode network (DMN). Quantitative long noncoding (lnc) RNA and mRNA expression data were related to peak T values of gFCDs using Pearson’s correlation coefficient analysis. Results Compared with the SCH-no AVH group ( n = 5), patients in the SCH-AVH group ( n = 5) exhibited differences in RNA expression in RNA networks that were related to AVH severity, and displayed alterations in FC (reflected by gFCD differences) within the DMN (posterior cingulate and dorsal-medial prefrontal cortex), and in the right parietal lobe, left occipital lobe, and left temporal lobe. Peak lncRNA expression values were significantly related to peak gFCD T values within the DMN. Conclusion Among patients with schizophrenia, there are concomitant FC and genetic expression alterations associated with AVHs. Data from pattern recognition studies may inform the development of an objective index aimed at improving early diagnostic accuracy and treatment planning for patients with schizophrenia with and without AVHs.

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“…Consideration of this literature was combined with discussion among the working group via video conferencing, email discussion, and at the fourth meeting of the ICHR in Lille, November 2017. 44 This article presents a narrative review which synthesizes the existing literature with themes from working group discussion of future developments.…”

mentioning

confidence: 99%

Potential Applications of Digital Technology in Assessment, Treatment, and Self-help for Hallucinations

Thomas

Bless

Alderson-Day

et al. 2019

Schizophrenia Bulletin

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The field of digital mental health is rapidly expanding with digital tools being used in assessment, intervention, and supporting self-help. The application of digital mental health to hallucinations is, however, at a very early stage. This report from a working group of the International Consortium on Hallucinations Research considers particular synergies between the phenomenon of hallucinations and digital tools that are being developed. Highlighted uses include monitoring and managing intermittently occurring hallucinations in daily life; therapeutic applications of audio and video media including virtual and augmented reality; targeting verbal aspects of hallucinations; and using avatars to represent hallucinatory voices. Although there is a well-established Internet-based peer support network, digital resources for hallucinations have yet to be implemented in routine practice. Implementation may benefit from identifying how to market resources to the broad range of populations who experience hallucinations and identifying sustainable funding models. It is envisaged that digital tools will contribute to improved self-management and service provision for people experiencing hallucinations.

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Hallucination Research: Into the Future, and Beyond

Cited by 11 publications

References 11 publications

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

A Review of Multimodal Hallucinations: Categorization, Assessment, Theoretical Perspectives, and Clinical Recommendations

Exploring concomitant neuroimaging and genetic alterations in patients with and patients without auditory verbal hallucinations: A pilot study and mini review

Potential Applications of Digital Technology in Assessment, Treatment, and Self-help for Hallucinations

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