Halo balloon cell nevus

Côté, Jean; Ak, Watters; Ea, O'Brien

doi:10.1111/j.1600-0560.1986.tb01512.x

Cited by 15 publications

(6 citation statements)

References 22 publications

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“…Halo nevus is a phenomenon involving several related conditions, including congenital melanocytic nevi, 7,8 Spitz nevi, 9,10 congenital giant nevocellular nevi, 7 balloon cell nevi, 11 and atypical nevi 12 among others. Histologically, there is progressive degeneration of nevus cells surrounded by an inflammatory infiltrate.…”

Section: Introductionmentioning

confidence: 99%

The Immunopathology of Regression in Benign Lichenoid Keratosis, Keratoacanthoma and Halo Nevus

Bayer‐Garner¹,

Ivan²,

Schwartz³

et al. 2004

Clinical Medicine & Research

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Cytotoxic T-cells may be the final common denominator of regression in benign lichenoid keratosis, keratoacanthoma, and halo nevus. In halo nevus, cytotoxic T-cells may play the predominant role in regression. In keratoacanthoma and benign lichenoid keratosis, cytotoxic T-cells play a pivotal role, but additional mechanisms may also be involved in the phenomenon of regression. Benign lichenoid keratoses progress through stages of regression accompanied by varying proportions of inflammatory cells, including CD3, CD4, and CD8 positive T-lymphocytes, natural killer cells, macrophages and Langerhans cells.

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Section: Introductionmentioning

confidence: 99%

The Immunopathology of Regression in Benign Lichenoid Keratosis, Keratoacanthoma and Halo Nevus

Bayer‐Garner¹,

Ivan²,

Schwartz³

et al. 2004

Clinical Medicine & Research

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“…Recent reports have identified the BCN as a variant of the nevocellular nevus 5–7 . Balloon‐cell change in association with other types of melanocytic proliferations has also been reported 8–10 . In the following report, we present a patient with balloon‐cell change occurring within a confirmed congenital melanocytic nevus.…”

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confidence: 73%

Proliferative nodules with balloon‐cell change in a large congenital melanocytic nevus

et al. 2006

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The balloon-cell nevus was first described over 100 years ago. Since then, balloon-cell changes of melanocytes have been noted in numerous tumors, including melanoma, blue nevus, and Spitz nevus. Whether these changes reflect cellular deterioration or proliferative changes is a matter of debate. We report a case in which balloon-cell changes were found within proliferative nodules occurring in a large congenital melanocytic nevus.

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“…Ballooning cell changes would be caused by an arrest of biosynthesis of melanin and would reflect an intrinsic cellular degenerative process, resulting in less pigmented than typical melanocytes. These kinds of cells are described not only in benign nevi including Spitz, combined halo, dysplastic, nodal, and blue nevi, 12–16 but also in malignant lesions, such as in melanoma of the skin, choroid, or conjunctiva 3,17–19 …”

Section: Discussionmentioning

confidence: 99%

Dermoscopy and reflectance confocal microscopy of balloon cell nevi: a series of 10 cases

Fusano¹,

Soglia

Gianotti

et al. 2021

Int J Dermatology

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Background Balloon cell nevus (BCN) is a rare histopathological entity. It is usually represented by an asymptomatic brown smooth or polypoid lesion, but no clinical features allow differentiation from other melanocytic nevi. Moreover, dermoscopy and reflectance confocal microscopy (RCM) aspects of BCN have been described in a few single cases. This study aims to describe a wider BCN series with dermoscopic and RCM features to assess the most frequent patterns. Methods Ten patients who underwent a BCN surgical excision with histological diagnosis were included in this study. Dermatoscopy and RCM were performed for each lesion, searching for the features described in literature. Results Each nevus presented as an asymptomatic, smooth brownish lesion. Regarding dermoscopy, four balloon cell nevi showed yellow globules, eight white globules, eight a light‐brown network at the periphery, and eight a structureless central area; moreover, we found a hyperpigmented central blotch in four cases. RCM examination highlighted aggregates of dense nests at superficial dermis level in all BCNs, characterized by the presence of a dark nucleus surrounded by vacuolized cytoplasm. Moreover, multiple melanophages were seen at the dermal–epidermal junction in one case and superficial epidermal dendritic cells in one case. Conclusions This series of 10 BCNs improves the dermoscopic and confocal microscopic knowledge of this rare entity. We also reported a new dermoscopic aspect represented by central hyperpigmented blotch. A correct identification of BCN with noninvasive techniques allows to avoid unnecessary surgical excision.

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Halo balloon cell nevus

Abstract: We report an unusual case occurring in a 25-year-old male of a balloon cell nevus which also showed clinical and pathological features of a halo nevus.

Cited by 15 publications

References 22 publications

The Immunopathology of Regression in Benign Lichenoid Keratosis, Keratoacanthoma and Halo Nevus

The Immunopathology of Regression in Benign Lichenoid Keratosis, Keratoacanthoma and Halo Nevus

Proliferative nodules with balloon‐cell change in a large congenital melanocytic nevus

Dermoscopy and reflectance confocal microscopy of balloon cell nevi: a series of 10 cases

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