Halogen and hydrogen bonding in the layered crystal structure of 2-iodoanilinium triiodide, C6H7I4N

Reiß, Guido J.

doi:10.1515/ncrs-2019-0127

Cited by 17 publications

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References 39 publications

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“…Iodine is an important microbicide and has many applications in the medical field, as commercial disinfectants, and against biohazards [ 20 , 23 , 24 , 25 , 26 ]. Complexed compounds with iodine are interesting materials and can be designed in the form of different polyiodides [ 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. Halogen bonding within the polyiodide units are “smart” reservoirs of molecular iodine [ 22 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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Antibiotic resistance is an eminent threat for the survival of mankind. Nosocomial infections caused by multidrug resistant microorganisms are a reason for morbidity and mortality worldwide. Plant-based antimicrobial agents are based on synergistic mechanisms which prevent resistance and have been used for centuries against ailments. We suggest the use of cost-effective, eco-friendly Aloe Vera Barbadensis Miller (AV)-iodine biomaterials as a new generation of antimicrobial agents. In a facile, one-pot synthesis, we encapsulated fresh AV gel with polyvinylpyrrolidone (PVP) as a stabilizing agent and incorporated iodine moieties in the form of iodine (I2) and sodium iodide (NaI) into the polymer matrix. Ultraviolet-visible spectroscopy (UV-Vis), Fourier transform infrared spectroscopy (FT-IR), x-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) verified the composition of AV-PVP-I2, AV-PVP-I2-NaI. AV, AV-PVP, AV-PVP-I2, AV-PVP-I2-NaI, and AV-PVP-NaI were tested in-vitro by disc diffusion assay and dip-coated on polyglycolic acid (PGA) sutures against ten microbial reference strains. All the tested pathogens were more susceptible towards AV-PVP-I2 due to the inclusion of “smart” triiodides with halogen bonding in vitro and on dip-coated sutures. The biocomplexes AV-PVP-I2, AV-PVP-I2-NaI showed remarkable antimicrobial properties. “Smart” biohybrids with triiodide inclusions have excellent antifungal and promising antimicrobial activities, with potential use against surgical site infections (SSI) and as disinfecting agents.

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Section: Introductionmentioning

confidence: 99%

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

2020

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“…Polyiodides consist of [I 2k+n ] n− units and are stabilized by donor-acceptor interactions of the combined iodine molecules and iodide ions [33][34][35]. Triiodides are the smallest examples of polyiodides and contain either symmetric or asymmetric [I-I-I] − groups, which are connected to each other by halogen and/or hydrogen bonding [36,37] Triiodides were successfully used in combination with phototherapy in wound healing [38,39]. Ideal, symmetric triiodide units are characterized by pure halogen bonding and can be identified by characteristic Raman stretching Pharmaceutics 2020, 12, 361 3 of 36 vibrations at 108 cm −1 due to the electron density redistribution during the formation of halogen bonds [27,40,41].…”

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confidence: 99%

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

et al. 2020

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The emergence of resistant pathogens is a burden on mankind and threatens the existence of our species. Natural and plant-derived antimicrobial agents need to be developed in the race against antibiotic resistance. Nanotechnology is a promising approach with a variety of products. Biosynthesized silver nanoparticles (AgNP) have good antimicrobial activity. We prepared AgNPs with trans-cinnamic acid (TCA) and povidone-iodine (PI) with increased antimicrobial activity. We synthesized also AgNPs with natural cinnamon bark extract (Cinn) in combination with PI and coated biodegradable Polyglycolic Acid (PGA) sutures with the new materials separately. These compounds (TCA-AgNP, TCA-AgNP-PI, Cinn-AgNP, and Cinn-AgNP-PI) and their dip-coated PGA sutures were tested against 10 reference strains of microorganisms and five antibiotics by zone inhibition with disc-and agar-well-diffusion methods. The new compounds TCA-AgNP-PI and Cinn-AgNP-PI are broad spectrum microbicidal agents and therefore potential coating materials for sutures to prevent Surgical Site Infections (SSI). TCA-AgNP-PI inhibits the studied pathogens stronger than Cinn-AgNP-PI in-vitro and on coated sutures. Dynamic light scattering (DLS), ultraviolet-visible spectroscopy (UV-Vis), Fourier Transform infrared spectroscopy (FT-IR), Raman, X-ray diffraction (XRD), microstructural analysis by scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) confirmed the composition of TCA-AgNP-PI and Cinn-AgNP-PI. Smart solutions involving hybrid materials based on synergistic antimicrobial action have promising future perspectives to combat resistant microorganisms.Pharmaceutics 2020, 12, 361 2 of 36 20,000 related deaths in the United States in 2017 only and remains to be one of the important infection-associated mortality reasons [11,12]. The formation of biofilms on biotic and abiotic surfaces [13] paved the way for biofilm antibiotic tolerance as another major health threat [14,15]. This additional problem hampers the treatment of infections, most often gives rise to chronic infections, in the worst case to therapeutic failure, severe morbidity, and mortality [4]. More than 80% of microbial infections are caused by microbial biofilm formation and pose a severe health risk because treatment with antibiotics remains ineffective [16]. The incidence of chronic wound infections is increasing globally to alarming levels [17]. Chronic wounds are marked by high bacterial colonization and infection rates, which can be treated only by novel therapeutic approaches other than the use of conventional antibiotics [18,19]. Chronic wound tissues can contain microbiomes of complex communities with coexisting fungal and bacterial colonies of different strains within biofilms [20]. According to this inter-kingdom model, fungi like Candida albicans can offer structures for other bacteria (S. aureus, P. aeruginosa, Streptococcus spp., E. faecalis, E. coli, and Acinetobacter baumannii etc.) to attach, form intricate biofilms, and increase the resistance against any ...

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“…The aminium group N1 forms weak hydrogen bonds with iodine atoms only, whereas the aminium group N2 forms normal to weak hydrogen bonds with two water molecules and one iodine (see the left part of the figure). [16,27,32,33] the asymmetry is dependent on the intermolecular interactions in the solid state, which are mainly hydrogen bonds in this case. The formal I4 2− anion is characterised by a I5-I6 single bond 2.7762(13) Å for the I 2 molecule [34] and two different medium strong halogen bonds [I4-I5 = 3.2538(10) Å, I6-I4′ = 3.3816(10) Å, ′ = 1−x, −1 + y, 1.5 − z].…”

Section: Commentmentioning

confidence: 93%

Crystal structure of bis(1,3-phenylenedimethanaminium) bis(triiodide) tetraiodide – water (1/2) , C₈H₁₆I₅N₂O

Reiß

2020

Zeitschrift Für Kristallographie - New Crystal Structures

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Halogen and hydrogen bonding in the layered crystal structure of 2-iodoanilinium triiodide, C₆H₇I₄N

Abstract: C6H7I4N, monoclinic, P21/m (no. 11), a = 9.2818(2) Å, b = 6.55289(16) Å, c = 11.0561(3) Å, β = 114.051(3)°, V = 614.08(3) Å3, Z = 2, Rgt(F) = 0.0180, wRref(F2) = 0.0367, T = 109(2) K.

Cited by 17 publications

References 39 publications

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Crystal structure of bis(1,3-phenylenedimethanaminium) bis(triiodide) tetraiodide – water (1/2) , C₈H₁₆I₅N₂O

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Halogen and hydrogen bonding in the layered crystal structure of 2-iodoanilinium triiodide, C6H7I4N

Abstract: C6H7I4N, monoclinic, P21/m (no. 11), a = 9.2818(2) Å, b = 6.55289(16) Å, c = 11.0561(3) Å, β = 114.051(3)°, V = 614.08(3) Å3, Z = 2, Rgt(F) = 0.0180, wRref(F2) = 0.0367, T = 109(2) K.

Cited by 17 publications

References 39 publications

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

Facile Synthesis of Antimicrobial Aloe Vera-“Smart” Triiodide-PVP Biomaterials

“Smart” Antimicrobial Nanocomplexes with Potential to Decrease Surgical Site Infections (SSI)

Crystal structure of bis(1,3-phenylenedimethanaminium) bis(triiodide) tetraiodide – water (1/2) , C8H16I5N2O

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Halogen and hydrogen bonding in the layered crystal structure of 2-iodoanilinium triiodide, C₆H₇I₄N

Crystal structure of bis(1,3-phenylenedimethanaminium) bis(triiodide) tetraiodide – water (1/2) , C₈H₁₆I₅N₂O