Halogenated Gallium Corroles:DNA Interaction and Photodynamic Antitumor Activity

Liu, Ling-Gui; Sun, Yanmei; Liu, Zeyu; Liao, Yuhui; Zeng, Lei; Ye, Yong; Liu, Haiyang

doi:10.1021/acs.inorgchem.0c03016

Cited by 20 publications

(11 citation statements)

References 49 publications

(42 reference statements)

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“…Interactive studies into Human Serum Albumin (HSA), the main carrier protein in the human bloodstream, are important as it is used in preliminary laboratory evaluations of pharmacokinetic parameters (offering interesting information before clinical evaluations) due to its ability to transport endogenous and exogenous compounds [ 11 , 12 , 13 , 14 , 15 ]. In the case of DNA interaction assays, the possible formation of a corrole-DNA adducts through intercalation or by major/minor groove interactions may induce structural changes in DNA and possible cell destruction by apoptosis or necrosis [ 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles

et al. 2023

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The trans-A2B-corrole series was prepared starting with 5-(pentafluorophenyl)dipyrromethene, which was then reacted with respective aryl-substituted aldehyde by Gryko synthesis. It was further characterized by HRMS and electrochemical methods. In addition, we investigated experimental photophysical properties (absorption, emission by steady-state and time-resolved fluorescence) in several solvents and TDDFT calculations, aggregation, photostability and reactive oxygen species generation (ROS), which are relevant when selecting photosensitizers used in photodynamic therapy and many other photo-applications. In addition, we also evaluated the biomolecule-binding properties with CT-DNA and HSA by spectroscopy, viscometry and molecular docking calculations assays.

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Section: Introductionmentioning

confidence: 99%

Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles

et al. 2023

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“… 58 Using labeling with Annexin V-FITC and propidium iodide (PI), apoptosis testing can be performed. 59 As shown in Figure 5 , BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs (10 μM) showed apoptosis-inducing characteristics, the apoptosis ratios were 14.8% and 23.2%, respectively. In contrast, the apoptosis ratio of BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs at the same concentration were higher than that of oxaliplatin (13.5%), and the apoptosis ratio of GO/Ga/HBrQ NPs was higher than that of cisplatin (17.2%) ( Figure 5F ), indicating that the GO/Ga/HBrQ NPs showed higher toxicity than oxaliplatin and cisplatin.…”

Section: Resultsmentioning

confidence: 85%

Gallium Metal−Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells

Wu¹,

Liao²,

Niu³

et al. 2023

IJN

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Background Gallium (III) metal-organic complexes have been shown to have the ability to inhibit tumor growth, but the poor water solubility of many of the complexes precludes further application. The use of materials with high biocompatibility as drug delivery carriers for metal-organic complexes to enhance the bioavailability of the drug is a feasible approach. Methods Here, we modified the ligands of gallium 8-hydroxyquinolinate complex with good clinical anticancer activity by replacing the 8-hydroxyquinoline ligands with 5-bromo-8-hydroxyquinoline (HBrQ), and the resulting Ga(III) + HBrQ complex had poor water solubility. Two biocompatible materials, bovine serum albumin (BSA) and graphene oxide (GO), were used to synthesize the corresponding Ga(III) + HBrQ complex nanoparticles (NPs) BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs in different ways to enhance the drug delivery of the metal complex. Results Both of BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs can maintain stable existence in different solution states. In vitro cytotoxicity test showed that two nanomedicines had excellent anti-proliferation effect on HCT116 cells, which shown higher level of intracellular ROS and apoptosis ratio than that of cisplatin and oxaliplatin. In addition, the superior emissive properties of BSA/Ga/HBrQ NPs and GO/Ga/HBrQ NPs allow their use for in vivo imaging showing highly effective therapy in HCT116 tumor-bearing mouse models. Conclusion The use of biocompatible materials for the preparation of NPs against poorly biocompatible metal-organic complexes to construct drug delivery systems is a promising strategy that can further improve drug delivery and therapeutic efficacy.

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“…Corrole 1 , 1‐Ga , 1‐P were synthesized according to the previous literature with slight modifications on the conditions(Scheme 1). [12,11k,l] 1‐Ga complex was prepared by the reflux of free base corroles and GaCl 3 using pyridine as solvent under a nitrogen atmosphere. 1‐P was obtained by refluxing the mixture of free base corrole 1 and PCl 3 in pyridine under the protection of N 2 .…”

Section: Resultsmentioning

confidence: 99%

Photodynamic Antitumor Activity of 5,15‐Bis(perfluorophenyl)‐10‐(4‐carboxyphenyl)corrole and its Gallium(III) and Phosphorus(V) Complexes

et al. 2022

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This work reports the preparation and characterization of an A 2 B corrole 5,15-bis(perfluorophenyl)-10-(4carboxyphenyl)corrole and its gallium(III) and phosphorus(V) complexes. Their in-vitro photodynamic anticancer activities against A549, MDA-MB-231, B16, HepG2, and Hela cell lines were also investigated. Among three compounds, phosphorus(V) complexexhibits the best photostability, highest fluorescence quantum yields (Φ F = 0.138), and the highest singlet-oxygen quantum yields (Φ Δ = 0.87). Also, the phosphorus(V) complex exhibits the best photodynamic antitumor activity against MDA-MB-231 cells with a low IC 50 (0.08 μM) upon light irradiation at 625 � 2 nm, which is much lower than commercial PDT drug Temoporfin (0.1 μM) at the same conditions. The cellular localization assay confirmed that the phosphorus(V) complexis mainly distributed in the cytoplasm and have a good ability to produce reactive oxygen species (ROS) under light illumination, which would further cause oxidative damage to tumor cells and finally result in the apoptosis. After PDT treatment, phosphorus(V) complex may cause tumor cell arrest at the G2/M stage. The preliminary results showed phosphorus(V) corrole complex is a good candidate for photodynamic therapy (PDT) of tumors.

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Halogenated Gallium Corroles:DNA Interaction and Photodynamic Antitumor Activity

Cited by 20 publications

References 49 publications

Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles

Effects of Substituents on the Photophysical/Photobiological Properties of Mono-Substituted Corroles

Gallium Metal−Organic Nanoparticles with Albumin-Stabilized and Loaded Graphene for Enhanced Delivery to HCT116 Cells

Photodynamic Antitumor Activity of 5,15‐Bis(perfluorophenyl)‐10‐(4‐carboxyphenyl)corrole and its Gallium(III) and Phosphorus(V) Complexes

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