2015
DOI: 10.1002/ange.201508155
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Halogenated Phenazines that Potently Eradicate Biofilms, MRSA Persister Cells in Non‐Biofilm Cultures, and Mycobacterium tuberculosis

Abstract: Conventional antibiotics are ineffective against nonreplicating bacteria (for example,bacteria within biofilms). We report as eries of halogenated phenazines (HP), inspired by marine antibiotic 1,t hat targets persistent bacteria. HP 14 demonstrated the most potent biofilm eradication activities to date against MRSA, MRSE, and VRE biofilms (MBEC = 0.2-12.5 mM), as well as the effective killing of MRSA persister cells in non-biofilm cultures.F rontline MRSA treatments,v ancomycin and daptomycin, were unable to … Show more

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Cited by 24 publications
(47 citation statements)
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“…In addition, 2,4‐diBr‐1‐OHPhz demonstrates no hemolysis activity at 200 μ m (highest test concentration), confirming that this HP was not eradicating biofilms through a membrane‐lysis mechanism, similar to QAC compounds . Positive biofilm eradication without hemolytic, or membrane‐lysing, activities provides some initial mechanistic insights and is ideal for the development of new therapeutic agents …”
Section: Phenazine Antibiotics: Inspiration For the Discovery Of New mentioning
confidence: 81%
See 4 more Smart Citations
“…In addition, 2,4‐diBr‐1‐OHPhz demonstrates no hemolysis activity at 200 μ m (highest test concentration), confirming that this HP was not eradicating biofilms through a membrane‐lysis mechanism, similar to QAC compounds . Positive biofilm eradication without hemolytic, or membrane‐lysing, activities provides some initial mechanistic insights and is ideal for the development of new therapeutic agents …”
Section: Phenazine Antibiotics: Inspiration For the Discovery Of New mentioning
confidence: 81%
“…We termed this focused series of compounds “halogenated phenazines” (HPs). In addition, 2,4‐diBr‐1‐OHPhz was found to have no cytotoxicity against HeLa cells at 100 μ m , demonstrating efficient bacterial targeting by this HP …”
Section: Phenazine Antibiotics: Inspiration For the Discovery Of New mentioning
confidence: 93%
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