Halogenated polycyclic aromatic hydrocarbons in edible aquatic species of two Asian countries: Congener profiles, biomagnification, and human risk assessment

Wickrama-Arachchige, Anura Upasanta-Kumara; Guruge, Keerthi S.; Inagaki, Yuriko; Tani, Hinako; Dharmaratne, Tilak Siri; Niizuma, Yasuaki; Ohura, Takeshi

doi:10.1016/j.foodchem.2021.130072

Cited by 19 publications

(23 citation statements)

References 37 publications

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“…These results are similar to the reported abundances of major Cl-PAH congeners in fly ash from coal-fired power plants, stack gas from copper smelters, stack gas from iron ore sintering plant, air (gas phase) from industrial parks in Korea, and air (gas phase) in Japan . The relative abundances of HPAHs in particulate matters − and some edible species , appear to differ from that observed in the serum of this work, suggesting that inhalation could be the most relevant exposure pathway of serum unmetabolized PAHs and HPAHs in our sampled population, although the possibility of exposure via other pathways cannot be ruled out.…”

Section: Resultssupporting

confidence: 86%

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Parent and Halogenated Polycyclic Aromatic Hydrocarbons in the Serum of Coal-Fired Power Plant Workers: Levels, Sex Differences, Accumulation Trends, and Risks

Zhao

Zhang

et al. 2022

Environ. Sci. Technol.

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Workers in coal-fired power plants are at a high risk of exposure to polycyclic aromatic hydrocarbons (PAHs) and their halogenated derivatives (HPAHs), yet no studies have investigated such exposure of HPAHs. In this study, 12 PAHs and 8 chlorinated PAHs, but no brominated PAHs, were detected in >80% of serum samples from workers of a coal-fired power plant in eastern China. Serum HPAH concentrations were higher in plant workers (16–273 ng/g lipid) than in people without occupational exposure (12–51 ng/g lipid), and serum PAH and HPAH concentrations both in male and female workers were positively correlated with the occupational exposure duration, with an estimated doubling time of 11–17 years. Correlations were found between concentrations of ∑8HPAHs and ∑12PAHs but not between 7-chlorobenz[a]anthracene (7-ClBaA) and 1-chloropyrene (1-ClPyr) and their respective parent PAHs. In males, total concentrations of PAHs and HPAHs were positively correlated with pulmonary hypofunction and hypertension but not with abnormal electrocardiogram. The benzo[a]pyrene equivalents ratio of ∑8HPAHs/∑12PAHs was 0.3 ± 0.1. Among the HPAHs in the serum, 9-chlorophenanthrene, 7-ClBaA, and 1-ClPyr showed high health risks. This study is the first report on HPAH exposure in coal-fired power plant workers and provides new evidence on the health risks of PAHs and HPAHs in humans.

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Section: Resultssupporting

confidence: 86%

“…have been detected in food (fish, pork, etc.) and the fly ash of coal-fired power plants, ,, almost no Br-PAHs were detected in the serum of this study. Exposure to Br-PAHs through inhalation of gas is low as few Br-PAHs distribute in the gas phase .…”

Section: Resultscontrasting

confidence: 49%

Parent and Halogenated Polycyclic Aromatic Hydrocarbons in the Serum of Coal-Fired Power Plant Workers: Levels, Sex Differences, Accumulation Trends, and Risks

Zhao

Zhang

et al. 2022

Environ. Sci. Technol.

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“…Therefore, HPAHs will also accumulate in the lipids of organisms through the food chain. At present, a large amount of HPAH accumulation has been found in organisms of high nutritional grade, 11 and 6-ClBaP has been detected in a variety of milk powder samples. 12 This leads researchers to think about the level of exposure to HPAHs in humans.…”

Section: Introductionmentioning

confidence: 99%

Ultrasensitive determination of 39 parent and emerging halogenated polycyclic aromatic hydrocarbons in human serum

Zhao

Wang

et al. 2022

Anal. Methods

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“…PCNs and Cl-PAHs are ubiquitous in multiple environmental matrices, including atmosphere, airborne particulate matter, soil, water, and sediments. − These compounds have been shown to be potentially immunotoxic and carcinogenic by binding to the aryl hydrocarbon receptor . Exposure to PCNs and Cl-PAHs occurs by inhalation, ingestion of contaminated food and water, and dermal contact. , These lipophilic compounds can accumulate and transfer through the food chain . PCNs have been found in human serum, adipose tissue, and liver, but Cl-PAHs have not been studied in human-derived specimens. , PCNs emitted from industrial thermal processes have been detected in breast milk, indicating potential health risks to infants .…”

Section: Introductionmentioning

confidence: 99%

“…6 Exposure to PCNs and Cl-PAHs occurs by inhalation, ingestion of contaminated food and water, and dermal contact. 6,7 These lipophilic compounds can accumulate and transfer through the food chain. 6 PCNs have been found in human serum, adipose tissue, and liver, but Cl-PAHs have not been studied in humanderived specimens.…”

Section: ■ Introductionmentioning

confidence: 99%

Insights into the Formation and Profile of Chlorinated Polycyclic Aromatic Hydrocarbons during Chlorobenzene and Chloroethylene Manufacturing Processes

Liu

Yang

Wang

et al. 2021

Environ. Sci. Technol.

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Chlorinated polycyclic aromatic hydrocarbons including chlorinated naphthalenes and congeners with three to five rings are ubiquitous atmospheric pollutants. Congener profiles and formation mechanisms from typical chemical manufacturing have not been researched extensively. We measured the concentrations of 75 chlorinated naphthalenes and 18 chlorinated polycyclic aromatic hydrocarbons in raw materials, intermediates, products, and bottom residues from chemical plants producing monochlorobenzene and chloroethylene by different techniques. The findings confirmed that these chemical manufacturing processes are newly identified sources of atmospheric emissions of these compounds. More-chlorinated naphthalenes were formed from chloroethylene production than from monochlorobenzene production, which could be explained by the higher temperatures in the former process. Successive chlorination appeared to be an important formation pathway of polychlorinated naphthalenes according to their congener profiles and was supported by quantum chemical calculations of electrophilic chlorination on various positions of naphthalene. Chlorinated polycyclic aromatic hydrocarbons were more likely to be formed during the production of monochlorobenzene than chloroethylene. Moreover, we suggested that ring rearrangement and ring coupling are important transformation reactions between polychlorinated naphthalenes and chlorinated polycyclic aromatic hydrocarbons.

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Halogenated polycyclic aromatic hydrocarbons in edible aquatic species of two Asian countries: Congener profiles, biomagnification, and human risk assessment

Cited by 19 publications

References 37 publications

Parent and Halogenated Polycyclic Aromatic Hydrocarbons in the Serum of Coal-Fired Power Plant Workers: Levels, Sex Differences, Accumulation Trends, and Risks

Parent and Halogenated Polycyclic Aromatic Hydrocarbons in the Serum of Coal-Fired Power Plant Workers: Levels, Sex Differences, Accumulation Trends, and Risks

Ultrasensitive determination of 39 parent and emerging halogenated polycyclic aromatic hydrocarbons in human serum

Insights into the Formation and Profile of Chlorinated Polycyclic Aromatic Hydrocarbons during Chlorobenzene and Chloroethylene Manufacturing Processes

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