Halonium Catalysis: An Underutilized and Underexplored Catalytic Concept in Olefin Functionalizations

Abstract

Iodonium catalysis is described here to accomplish an intermolecular olefin oxyamination reaction. Urea is used as the O- and N-source to add across both activated and un-activated alkenes in a regioselective manner. Mechanistic studies confirm the presence of an iodonium intermediate.

I2/DTBP Promoted Synthesis of C3-Carbonylated Imidazopyridines from Chromones and 2-Aminopyridines via (3+2) Cycloaddition

“…Thus, the solvent effect was further considered, and the slight increasing yield of 3a was observed under toluene as the solvent (entries [6][7][8][9][10][11]. Basing on the known literatures, 14 the addition of I2 might play a crucial role in this transformation via the coordination of iodine with the double bond. Indeed, no desired product 3a was detected in the absence of I2 (entry 12).…”