Haloperidol and chlorpheniramine interaction in inhibitory avoidance in goldfish

Chlorpheniramine facilitates inhibitory avoidance in teleosts submitted to telencephalic ablation

“…These data suggest both the effectiveness of the model proposed and the adequacy of the aversive stimulus used. Moreover, we have published data on unoperated groups that indicated that the inhibitory avoidance model used in the present study affects learning and memory and has also been sensitive to histaminergic drugs (7,8).…”

“…Previous studies suggested an innate preference of teleost fish for dark environments (9). In studies in which the same model of inhibitory avoidance task was used, fish took longer to leave the white compartment of the aquarium after experiencing aversive stimulus immediately after crossing to the dark compartment (7,8,11). These data suggest both the effectiveness of the model proposed and the adequacy of the aversive stimulus used.…”

“…On training days, the fish were placed individually in the white compartment and after 30 s the door was opened and the time spent for crossing into the black compartment was recorded (latency). When the fish crossed to the black compartment, a 45-g weight (aversive stimulus) was dropped in front of it (7,8). Thereafter, the fish crossed back or was immediately returned to the start compartment and the procedure was repeated twice.…”

L-histidine reduces inhibitory avoidance in Carassius auratus submitted to cerebellar ablation

“…A previous study has also shown that goldfish submitted to cerebellar ablation were able to acquire a conditioned bradycardia response (emotional conditioning) (19). In addition, goldfish submitted to telencephalic ablation have been shown to acquire inhibitory avoidance (17). In contrast, other studies have shown that complete removal of the cerebellum affected the learning of classical conditioning by goldfish (20,21).…”

“…In this procedure, learning is inferred when the animal reduces its preference for dark places, which is an innate behavior of the species (16), associating the black compartment with an aversive experience. Several studies have used this model to investigate the action of different drugs on learning and memory processes and on processes of functional recovery in goldfish, indicating that the model is appropriate for this purpose (11,17,18).…”