Haloperidol for agitation in dementia

Lonergan, Edmund; Luxenberg, Jay S.; Colford, John M.; Birks, Jacqueline

doi:10.1002/14651858.cd002852

Cited by 143 publications

(96 citation statements)

References 50 publications

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“…Haloperidol wird seit Jahrzehnten zur Behandlung von Agitiertheit, unter der bis zu 70% der Dementen leiden, eingesetzt. Der routinemäßige Einsatz von Haloperidol zur Behandlung von Agitiertheit bei Demenz wurde als Ergebnis eines Cochrane Reviews (Lonergan et al, 2004) insbesondere im Hinblick auf die Nebenwirkungen als nicht gerechtfertigt bewertet.…”

Section: Ergebnisse Aus Den Weiteren Bewohnerinnenbezogenenunclassified

Psychopharmakologische Behandlungspraxis in Münchener Altenpflegeheimen

Molter-Bock

Hasford

Pfundstein³

2006

Z Gerontol Geriatr

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Section: Ergebnisse Aus Den Weiteren Bewohnerinnenbezogenenunclassified

Psychopharmakologische Behandlungspraxis in Münchener Altenpflegeheimen

Molter-Bock

Hasford

Pfundstein³

2006

Z Gerontol Geriatr

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“…Some studies suggest the prevalence of inappropriate sexual behaviours (ISB) amongst residents with dementia is relatively low (Alagiakrishnan et al, 2005;ILCUK, 2011;Series & Degano, 2005), but others claim that their prevalence and impact are substantial (Cubit et al, 2007;Lonergan et al, 2002;Scott et al, 2002). ISB is often seen as a part of the symptom cluster of behavioral and psychiatric disturbances associated with dementia, which is often disruptive and distressing for both patient and their carers (Johnson, Knight & Alderman, 2006).…”

Section: Introductionmentioning

confidence: 99%

“Behind Closed Doors with open minds?”: A qualitative study exploring nursing home staff’s narratives towards their roles and duties within the context of sexuality in dementia

Vandrevala

Chrysanthaki

Ogundipe

2017

International Journal of Nursing Studies

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“…Antipsychotic drugs are often among the medications prescribed to elderly patients to control symptoms of psychosis and the behavioral disturbances associated with dementia. Unfortunately, these medications appear to be less effective and produce more serious side effects in such older individuals (Lonergan et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation

Montalvo-Ortiz

Keegan

Gallardo

et al. 2013

Neuropsychopharmacol

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Antipsychotic drugs are widely prescribed to elderly patients for the treatment of a variety of psychopathological conditions, including psychosis and the behavioral disturbances associated with dementia. However, clinical experience suggests that these drugs may be less efficacious in the elderly individuals than in the young. Recent studies suggest that aging may be associated with epigenetic changes and that valproic acid (VPA), a histone deacetylase inhibitor, may reverse such changes. However, it is not yet known whether HDAC inhibitors can modulate age-related epigenetic changes that may impact antipsychotic drug action. In this study, we analyzed conditioned avoidance response (CAR) and c-Fos expression patterns to elucidate the effect of HDAC inhibitors VPA and entinostat (MS-275) on behavioral and molecular markers of the effects of haloperidol (HAL) in aged mice. Our results showed that HAL administration failed to suppress the avoidance response during the CAR test, suggesting an age-related decrease in drug efficacy. In addition, HAL-induced c-Fos expression in the nucleus accumbens shell and prefrontal cortex was significantly lower in aged mice as compared with young mice. Pretreatment with VPA and MS-275 significantly improved HAL effects on the CAR test in aged mice. Also, VPA and MS-275 pretreatment restored HAL-induced increases in c-Fos expression in the nucleus accumbens shell and prefrontal cortex of aged mice to levels comparable with those observed in young mice. Lastly, but most importantly, increases in c-Fos expression and HAL efficacy in the CAR test of the HAL þ VPA and HAL þ MS-275 groups were correlated with elevated histone acetylation at the c-fos promoter region in aged mice. These findings suggest that pretreatment with VPA or MS-275 increases the behavioral and molecular effects of HAL in aged mice and that these effects occur via modulation of age-related histone hypoacetylation in the nucleus accumbens shell and prefrontal cortex.

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Haloperidol for agitation in dementia

Cited by 143 publications

References 50 publications

Psychopharmakologische Behandlungspraxis in Münchener Altenpflegeheimen

Psychopharmakologische Behandlungspraxis in Münchener Altenpflegeheimen

“Behind Closed Doors with open minds?”: A qualitative study exploring nursing home staff’s narratives towards their roles and duties within the context of sexuality in dementia

HDAC Inhibitors Restore the Capacity of Aged Mice to Respond to Haloperidol through Modulation of Histone Acetylation

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