Halothane and Isometric Contractions of Isolated Pregnant Rat Myometrium

Naffalin, Nicholas J.; Phear, W. P. C.; Goldberg, Alan H.

doi:10.1097/00000542-197504000-00016

Cited by 13 publications

(5 citation statements)

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“…This was contradicted by a study [23] reporting that, during 1.0-to 1.5-MAC anesthesia with isofl urane, uterine blood fl ow increased slightly or remained unchanged, until 2.0 MAC of isofl urane was administered. These changes were attributed to the relaxing effect of the anesthetic on the myometrium [24][25][26][27], leading to a reduction in uterine vascular resistance. In the present study, uterine blood fl ow remained essentially unchanged.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep

et al. 2009

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Section: Discussionmentioning

confidence: 99%

Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep

et al. 2009

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“…Halothane 0.25% Halothane 0.5% Enflurane 0.5% Enflurane l'y, n = I6 n = 16 n = 18 n = 18 n;: I3 to produce a dose-related decrease in uterine contractability and tone (16)(17)(18)(19). However, findings from our study as well as other studies have failed to reveal any increased blood loss with the use of low dose halothane (6, 7), or enflurane 0.5-1.5y0 (12).…”

Section: N20mentioning

confidence: 99%

Comparative Maternal and Neonatal Effects of Halothane and Enflurane for Cesarean Section

Abboud

Kim

Henriksen

et al. 1986

Obstetric Anesthesia Digest

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The effects of placental transfer of enflurane and halothane were studied in 81 women undergoing cesarean sections. All patients had rapid sequence induction using thiopental, succinylcholine, and endotracheal intubation. They were then randomly assigned to one of five groups: Group I ( n = 16) received N z 0 and oxygen, Group I1 ( n = 16) N20, oxygen, and 0.25% halothane, Group 111 ( n = 18) NzO, oxygen, and 0.50/, halothane, Group IV ( n = 18) NzO, oxygen, and 0.5% enflurane, Group V ( n = 13) NzO, oxygen, and 1% enflurane. At delivery, blood was drawn from the maternal artery, umbilical vein and artery for measurement of the halogenated agents using gas chromatography. The neonates were evaluated by Apgar scores, umbilical artery and vein acid base status and the Early Neonatal Neurobehavioral Scores (ENNS) at 2 and 24 h of age. Blood loss and the incidence of maternal awareness were also determined. The umbilical vein to maternal vein ratio was approximately 0.5 and 0.6 for enflurane and halothane, respectively. The umbilical artery to umbilical vein ratio was 0.5 with both agents; higher inspired anesthetic concentrations produced higher blood levels. All neonates had Apgar scores of 8 or more at 5 min with the exception of one neonate in the NzO group. Maternal and neonatal acid base status, blood loss, and ENNS were not affected by the addition of the halogenated agents. Of the patients who had N20 alone, 12% had awareness versus none in the other groups. These data demonstrate that low dose halothane or enflurane decreases the incidence of maternal awareness and does not adversely affect the neonate.

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“…Volatile anesthetics have direct dose‐related tocolytic effects on myometrial contractions (1–5). Desflurane was safely used in analgesia for vaginal delivery (6).…”

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confidence: 99%

Inhibitory effects of desflurane and sevoflurane on contractions of isolated gravid rat myometrium under oxytocin stimulation

Doğru

Yildiz²,

Dalgiç

et al. 2003

Acta Anaesthesiol Scand

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Halothane and Isometric Contractions of Isolated Pregnant Rat Myometrium

Cited by 13 publications

References 0 publications

Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep

Comparison of the effects of sevoflurane and isoflurane anesthesia on the maternal-fetal unit in sheep

Comparative Maternal and Neonatal Effects of Halothane and Enflurane for Cesarean Section

Inhibitory effects of desflurane and sevoflurane on contractions of isolated gravid rat myometrium under oxytocin stimulation

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