Halotolerant Bacillus Sp. As a Source of Antifungal Agents Against Major Mushroom Pathogens

Fernandes, Michelle S.; Kerkar, Savita

doi:10.15414/jmbfs.2019.8.5.1125-1129

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…These microorganisms have proved to be a valuable source of biomolecules that find their applications in various fields such as the environment, industry and medicine. Despite recent advances, the use of extremophilic metabolites is very limited, especially in medical applications (Fernandes & Kerkar, 2021; Torres et al, 2019). In this context, Bacillus spp.…”

Section: Introductionmentioning

confidence: 99%

Quorum quenching and anti-biofilm activities of halotolerant Bacillus strains isolated in different environments in Algeria

Aichar

Muras

Parga

et al. 2022

Journal of Applied Microbiology

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Aims The current study aimed to screen Bacillus strains with wide‐spectrum quorum quenching (QQ) activity against N‐acyl‐l‐homoserine lactones (AHLs), helpful in controlling virulence traits in Gram‐negatives, including biofilm formation and also with anti‐biofilm activity against Gram‐positives. Methods and Results A total of 94 halotolerant strains of Bacillus isolated from soil and salt‐lake sediment samples in Algeria were examined for the presence of QQ activity against AHLs, the presence of the aiiA gene, encoding an AHL lactonase enzyme typical of Bacillus spp., antimicrobial and anti‐biofilm activities against Pseudomonas aeruginosa and Streptococcus mutans. Of all strains of Bacillus spp. isolated, 48.9% showed antibacterial activity. In addition, 40% of these isolates showed a positive QQ activity against long‐chain AHLs, of which seven strains presented the aiiA gene. Among the species with broad‐spectrum QQ activity, the cell extract of Bacillus thuringiensis DZ16 showed antibiofilm activity against P. aeruginosa PAO1, reducing 60% using the Amsterdam active attachment (AAA) biofilm cultivation model. In addition, the cell extract of B. subtilis DZ17, also presenting a broad‐spectrum QQ activity, significantly reduced Strep. mutans ATCC 25175 biofilm formations by 63% and 53% in the xCELLigence and the AAA model, respectively, without affecting growth. Strain DZ17 is of particular interest due to its explicit halophilic nature because it can thrive at salinities in the range of 6%–30%. Conclusions B. thuringiensis DZ16 and B. subtilis DZ17 strains have interesting antibacterial, QQ, and anti‐biofilm activities. The high range of salinities accepted by these strains increases their biotechnological potential. This may open up their use as probiotics, the treatment and prevention of conventional and emerging infectious diseases. Significance and Impact of Study The use of safe, economical and effective probiotics is limited to control the infections related to multi‐resistant bacteria. In our study, we provide two promising agents with QQ, anti‐biofilm and antibacterial activities.

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Section: Introductionmentioning

confidence: 99%

Quorum quenching and anti-biofilm activities of halotolerant Bacillus strains isolated in different environments in Algeria

Aichar

Muras

Parga

et al. 2022

Journal of Applied Microbiology

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High-Yield-Related Genes Participate in Mushroom Production

Wang,

Li,

Han

et al. 2024

JoF

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In recent years, the increasing global demand for mushrooms has made the enhancement of mushroom yield a focal point of research. Currently, the primary methods for developing high-yield mushroom varieties include mutation- and hybridization-based breeding. However, due to the long breeding cycles and low predictability associated with these approaches, they no longer meet the demands for high-yield and high-quality varieties in the expansive mushroom market. Modern molecular biology technologies such as RNA interference (RNAi) and gene editing, including via CRISPR-Cas9, can be used to precisely modify target genes, providing a new solution for mushroom breeding. The high-yield genes of mushrooms can be divided into four categories based on existing research results: the genes controlling mycelial growth are very suitable for genetic modification; the genes controlling primordium formation are directly or indirectly regulated by the genes controlling mycelial growth; the genes controlling button germination are more difficult to modify; and the genes controlling fruiting body development can be regulated during the mycelial stage. This article reviews the current research status for the four major categories of high-yield-related genes across the different stages of mushroom growth stages, providing a foundation and scientific basis for using molecular biology to improve mushroom yield and promote the economic development of the global edible-mushroom industry.

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The input of microorganisms to the cultivation of mushrooms on lignocellulosic waste

Saubenova¹,

ОЛЕЙНИКОВА²,

Sadanov³

et al. 2023

AIMSAGRI

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<abstract> <p>Lignocellulosic crop waste is the world's most abundant renewable raw material. Its burning leads to the loss of an energy valuable resource and causes enormous environmental damage. An environmentally friendly and promising biotechnological process for such waste utilization is the production of mushrooms for food and medicine. However, the energy intensity of substrate preparation hinders the development of work in this direction. Another significant challenge in this field is to increase the biological efficiency of substrate processing. The purpose of our investigation was to reveal the contribution of microorganisms to solving this and other problems of mushroom cultivation based on a review of the latest scientific research on the topic. The literature from databases of Google Scholar, Scopus, and Web of Science was selected by various combinations of search queries concerning mushrooms, substrates, microbial communities, and their effects. The current state of the issue of mushrooms and microorganisms' interactions is presented. The review considers in detail the contribution of microorganisms to the substrate preparation, describes microbial communities in various phases of the mushroom cultivation process, and identifies the main groups of microorganisms associated with lignocellulose degradation, mushroom growth promotion, and protection against pathogens. The significant contribution of bacteria to mushroom cultivation is shown. The review demonstrates that the contribution of bacteria to lignin degradation in lignocellulosic substrates during mushroom cultivation is largely underestimated. In this process, various genera of the bacterial phyla <italic>Bacillota</italic>, <italic>Pseudomonadota</italic>, and <italic>Actinomycetota</italic> are involved. The correct combinations of microorganisms can provide controllability of the entire cultivation process and increase required indicators. However, expanding research in this direction is necessary to remove gaps in understanding the relationship between microorganisms and mushrooms.</p> </abstract>

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Halotolerant Bacillus Sp. As a Source of Antifungal Agents Against Major Mushroom Pathogens

Cited by 3 publications

References 29 publications

Quorum quenching and anti-biofilm activities of halotolerant Bacillus strains isolated in different environments in Algeria

Quorum quenching and anti-biofilm activities of halotolerant Bacillus strains isolated in different environments in Algeria

High-Yield-Related Genes Participate in Mushroom Production

The input of microorganisms to the cultivation of mushrooms on lignocellulosic waste

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