HAMLET, protein folding, and tumor cell death

Mok, K. Hun; Pettersson, Jenny; Orrenius, Sten; Svanborg, Catharina

doi:10.1016/j.bbrc.2006.12.167

Cited by 70 publications

(54 citation statements)

References 52 publications

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“…HAMLET (human a-lactalbumin made lethal to tumor cells) is a molecular protein-lipid complex with tumoricidal activity (6). HAMLET is formed from human a-lactalbumin, which is the major protein in human milk (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Histone Deacetylase Inhibitors Promote the Tumoricidal Effect of HAMLET

et al. 2007

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Histone deacetylase inhibitors (HDIs) and HAMLET (human Alactalbumin made lethal to tumor cells) interact with histones, modify the structure of chromatin, and trigger tumor cell death. This study investigated how the combination of HDIs and HAMLET influences cell viability, histone acetylation, and DNA integrity. The pretreatment of tumor cells with HDIs was shown to enhance the lethal effect of HAMLET and the histone hyperacetylation response to HDIs increased even further after HAMLET treatment. HDIs and HAMLET were shown to target different histone domains as HAMLET bound tailless core histones, whereas HDIs modify the acetylation of the histone tail. DNA damage in response to HAMLET was increased by HDIs. The DNA repair response (p21WAFI expression) was induced by both agonists but abolished when the two agonists were combined. The results suggest that the synergy of HDIs and HAMLET is based on different but converging death pathways, both involving chromatin alterations. We speculate that HAMLET and HDIs might be combined to promote tumor cell death in vivo.

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Section: Introductionmentioning

confidence: 99%

Histone Deacetylase Inhibitors Promote the Tumoricidal Effect of HAMLET

et al. 2007

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“…Sixty different types of amyloid protein have been identified so far, and thirty-six have been connected with deposition disease. 7,8 For example, AA amyloidosis is caused by the deposition of an acute phase reactant protein in various organs. This acute phase reactant is usually generated in the setting of inflammatory disease (inflammatory bowel disease, rheumatoid arthritis, etc) or chronic infection (tuberculosis, chronic osteomyelitis, etc).…”

Section: Discussionmentioning

confidence: 99%

An Uncommon Presentation of Amyloidosis

Kujawski¹,

Johnson²,

Radadia³

et al. 2015

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“…In the last few years, a remarkable apoptotic-like activity toward cultured cancer cells of a complex between the calcium-free form of human α-LA and oleic acid has been described (Mok et al, 2007). The complex could either be isolated from human milk (Håkansson et al, 1995) or formed on a diethylaminoethyl trisacryl column equilibrated with OA (Svensson et al, 2000).…”

Section: Discussionmentioning

confidence: 99%