Hand functions in systemic lupus erythematosus: a comparative study with rheumatoid  arthritis patients and healthy subjects

Yentür, Songül Bağlan; Tunà, Zeynep; Mete, Oğuzhan; Gokkurt, A.; Töre, Nurten Gizem; Küçük, Hamit; Göker, Berna; Oskay, Deran

doi:10.3906/sag-1803-183

Cited by 6 publications

(6 citation statements)

References 12 publications

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“…Balsamo et al [ 17 ] demonstrated lower dynamic muscle strength along with increased fatigue, reduced functional performance and poorer quality of life in 25 premenopausal SLE patients with low disease activity vs 25 controls matched for age, physical characteristics and the level of physical activity. Bağlan Yentür et al [ 14 ] showed worse hand function in 46 SLE patients (all female) vs 46 healthy controls, but better in comparison to 51 RA patients. All these studies had a smaller sample size than the present study, and none evaluated any potential associations between hand function parameters and disease-related characteristics.…”

Section: Discussionmentioning

confidence: 99%

“…To date, a limited number of studies have assessed the hand function and performance of daily activities in SLE patients compared with healthy controls [ 13 , 14 ], and only sporadic studies [ 15–17 ] have examined the impact of demographic and disease-related characteristics on hand function abnormalities. We hypothesized that SLE patients present impaired hand function and difficulties in performance of ADLs, even those with low disease activity.…”

Section: Introductionmentioning

confidence: 99%

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Impaired hand function and performance in activities of daily living in systemic lupus erythematosus, even in patients achieving lupus low disease activity state (LLDAS)

Keramiotou

Anagnostou

Konstantonis

et al. 2021

Rheumatology Advances in Practice

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Objective To examine hand function and performance in activities of daily living (ADL) in patients with systemic lupus erythematosus (SLE) vs healthy controls, and any associations with demographic and disease–related characteristics. Methods Hand function (grip strength, pinch strength, dexterity) and ADL performance were evaluated in 240 patients with SLE and 122 age- and gender-matched healthy controls. Grip strength, pinch strength, and dexterity were measured by Jamar dynamometer, pinch gauge, and Purdue pegboard test, respectively. Self-reported ADL performance was assessed by Disabilities of the Arm, Shoulder and Hand (DASH) and Health Assessment Questionnaire (HAQ). Regression analysis was performed to assess the determinants of hand dysfunction. Results All hand function and ADL performance variables were significantly impaired in the entire SLE cohort and the subgroup of patients achieving lupus low disease activity state (LLDAS) (n = 157) compared to healthy subjects (p < 0.05). Joint pain, often underestimated in SLE, was the major determinant of hand function and ADL performance in multiple regression models. In addition, age was correlated with grip strength and Purdue scores, gender with grip strength, arthritis with DASH and HAQ and immunosuppressives use with DASH, HAQ and grip strength. Similarly, in patients in LLDAS, painful joints correlated with DASH and HAQ, age with grip strength and Purdue (p < 0.001), gender with grip strength and immunosuppressives with HAQ and grip strength. Conclusion Hand function and daily activities performance are significantly impaired in SLE, even in patients who achieved LLDAS, suggesting the need for their evaluation and management in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impaired hand function and performance in activities of daily living in systemic lupus erythematosus, even in patients achieving lupus low disease activity state (LLDAS)

Keramiotou

Anagnostou

Konstantonis

et al. 2021

Rheumatology Advances in Practice

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“…Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a significant impact on function, activities of daily living, work ability and patients’ quality of life 1–5. It has been well documented that upper limb exercise is beneficial to patients with rheumatic disorders such as rheumatoid arthritis,6 7 psoriatic arthritis8 and osteoarthritis 9.…”

Section: Introductionmentioning

confidence: 99%

The impact of upper limb exercise on function, daily activities and quality of life in systemic lupus erythematosus: a pilot randomised controlled trial

et al. 2020

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ObjectiveTo assess the effect of upper limb exercise on hand function, daily activities performance and quality of life of patients with systemic lupus erythematosus (SLE).MethodsWe performed a pilot randomised, 24-week follow-up, unmasked controlled trial. Inclusion criteria were upper limb arthralgias, a Disabilities of Arm, Shoulder and Hand (DASH) questionnaire score >10 and a stable treatment over the past 3 months. Patients were randomly allocated in the routine care (control) or exercise group that received an individually tailored 30-min daily upper-limb exercise programme by a hand therapist for 12 weeks. We evaluated at 0, 6, 12 and 24 weeks the performance of daily activities for both groups with DASH questionnaire and Health Assessment Questionnaire (HAQ), the grip and pinch strength with Jamar dynamometer and pinch gauge tool, respectively, the dexterity with Purdue pegboard test, the quality of life with Lupus Quality of Life (LupusQoL) Questionnaire and the pain level by Visual Analogue Scale (VAS) score.ResultsFrom 293 consecutive SLE patients, data from 32 patients allocated to the exercise group and 30 to the control group were analysed. There was a significant difference between the two groups in percentage changes of DASH, HAQ, grip strength, pinch strength, LupusQoL-physical health and fatigue, and VAS scores from baseline to 6, 12 and 24 weeks, and from baseline to 12 weeks for dexterity test (p<0.001). No interaction was observed between exercise and disease activity or medication use at baseline and during the observation period.ConclusionUpper-limb exercise significantly improves hand function, pain, daily activity performance and quality of life in SLE.Trial registration numberNCT03802578.

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“…Systemic lupus erythematosus, a rheumatic disease, frequently affects the small joints of the wrist and hands. 1,2 Arthropathy of the hands in systemic lupus erythematosus reduces the ability of twothirds of individuals to perform daily activities periodically or permanently [1][2][3][4] and makes it difficult for them to return to their occupation. 5,6 The musculoskeletal manifestations of arthropathy of the hands in patients with systemic lupus erythematosus include persistent pain, swelling, stiffness, decreases handgrip strength, and disability.…”

Section: Introductionmentioning

confidence: 99%

“…5,6 The musculoskeletal manifestations of arthropathy of the hands in patients with systemic lupus erythematosus include persistent pain, swelling, stiffness, decreases handgrip strength, and disability. 1,3,7 Restoration of normal hand function in patients with arthropathy of the hands is a goal that is necessarily subordinate to sustain life. Grasping and transporting objects are the frequently encountered tasks in the activities of daily livings, and its dysfunctions have a severe impact on the patient's normal life.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of high-intensity laser therapy on arthropathy of the hands in patients with systemic lupus erythematosus: a double-blinded, randomized controlled trial

2020

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Objective: To determine the efficacy of high-intensity laser therapy (HILT) on arthropathy of the hands in patients with systemic lupus erythematosus. Design: A double-blinded randomized, controlled study. Setting: Outpatient setting Participants: Fifty patients, 30–50-years-old, suffering from arthropathy of the hands were randomly assigned either into the experimental group, received HILT plus the routine physical therapy program or the control group, received sham HILT plus the same routine physical therapy program. Intervention: All treatment interventions were applied at a frequency of three sessions per week for eight weeks. Outcome measures: Handgrip strength, joints swelling counts, joints tenderness counts, visual analog scale (VAS) were measured before and after eight-weeks of interventions. Results: There were statistically significant differences in handgrip strength, joint swelling count, joint tenderness count and VAS in favor of the study group ( P < 0.05). After eight-weeks of intervention, the mean (SD) for handgrip strength, joint swelling counts, joint tenderness count, and pain score was 28.34 ± 8.3 kg, 4.4 ± 2.18, 5 ± 2.1, and 35.6 ± 13.87 mm in the study group, and 22.96 ± 8.76 kg, 7.36 ± 2.14, 9.08 ± 1.63, and 58.8 ± 10.54 mm in the control group, respectively. The MD (95%CI) for handgrip strength, joint swelling counts, joint tenderness count, and pain score was 5.38(0.53,10.23) kg, −2.96(−4.19, −1.73), −4.08(−5.15, −3.01), and −23.2(−30.2, −16.2) mm between groups, respectively. Conclusions: Adding HILT to the routine physical therapy program might be more effective than routine physical therapy program alone in improving handgrip strength, decreasing joint swelling counts, joint tenderness counts, and pain in patients with arthropathy of the hands.

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Hand functions in systemic lupus erythematosus: a comparative study with rheumatoid arthritis patients and healthy subjects

Abstract: Similar to patients with RA, hand functions are significantly impaired in patients with SLE in daily activities.

Cited by 6 publications

References 12 publications

Impaired hand function and performance in activities of daily living in systemic lupus erythematosus, even in patients achieving lupus low disease activity state (LLDAS)

Impaired hand function and performance in activities of daily living in systemic lupus erythematosus, even in patients achieving lupus low disease activity state (LLDAS)

The impact of upper limb exercise on function, daily activities and quality of life in systemic lupus erythematosus: a pilot randomised controlled trial

Efficacy of high-intensity laser therapy on arthropathy of the hands in patients with systemic lupus erythematosus: a double-blinded, randomized controlled trial

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