Hand-Held Diode Laser for On-Site Analysis Using Transportable Mass Spectrometry

Arrizabalaga-Larrañaga, Ane; Nielen, Michel W. F.; Blokland, Marco

doi:10.1021/acs.analchem.1c01083

Cited by 10 publications

(10 citation statements)

References 31 publications

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“…It is well known that thermal stress leads to the degradation of the optical power of LEDs, which eventually shortens their lifetime [ 29 ]. At the same time, laser devices are becoming smaller, battery-powered, and have an adjustable spot size [ 30 , 31 , 32 ]. The narrow emission spectrum of laser light enables precise targeting to the maximum absorption spectrum of photoinitiators.…”

Section: Introductionmentioning

confidence: 99%

Blue Laser for Polymerization of Bulk-Fill Composites: Influence on Polymerization Kinetics

et al. 2023

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The objective of this study was to compare the polymerization kinetics of bulk-fill resin composites cured with a LED-curing device and a diode laser (449 nm). Three bulk-fill composites were light-cured with constant radiation exposure at 10 J/cm2 by varying radiant exitance and curing time. The following three light-curing protocols were used: (I) 3300 mW/cm2 for 3 s; (II) 2000 mW/cm2 for 5 s; and (III) 1000 mW/cm2 for 10 s. The degree of conversion (DC) was monitored in real time at a data acquisition rate of 2 spectra/s over a 5-min period and again after seven days using Fourier transform infrared spectroscopy. DC amounted to 30.9–61.7% at 4-mm depth after 5 min. DC values of two sculptable composites were significantly higher with the laser, regardless of the curing protocol used, but not for the flowable composite. The maximum polymerization rate (2.0–22.1%/s) was less affected by the type of curing device for one of the composites, while the other two composites achieved significantly higher values when cured with the laser. Laser curing generally increased the DC and the maximum polymerization rate while it shortened the onset of the maximum reaction rate. New handheld laser devices with adjustable power have the potential to be used as a photopolymerization light source for new generations of bulk-fill composites.

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Section: Introductionmentioning

confidence: 99%

Blue Laser for Polymerization of Bulk-Fill Composites: Influence on Polymerization Kinetics

et al. 2023

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“…Recently, the applications of ambient ionization to drugs analysis have extended beyond the laboratory, with research focusing on the development of hand‐held tools and methods that could be used in the field for the analysis of real‐world samples to truly test the feasibility of such techniques. One recent study developed a hand‐held laser diode thermal DESI MS method for the rapid analysis of solid illegal materials 64 . The ion source consists of a hand‐held diode laser operating at 940 nm for analyte desorption that is positioned directly in front of the MS inlet.…”

Section: Applications Of Ambient Ionization Mass Spectrometrymentioning

confidence: 99%

Applications of ambient ionization mass spectrometry in 2021: An annual review

Rankin‐Turner

Reynolds

Turner

et al. 2022

Analytical Science Advances

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Ambient ionization mass spectrometry (AIMS) has revolutionized the field of analytical chemistry, enabling the rapid, direct analysis of samples in their native state. Since the inception of AIMS almost 20 years ago, the analytical community has driven the further development of this suite of techniques, motivated by the plentiful advantages offered in addition to traditional mass spectrometry. Workflows can be simplified through the elimination of sample preparation, analysis times can be significantly reduced and analysis remote from the traditional laboratory space has become a real possibility. As such, the interest in AIMS has rapidly spread through analytical communities worldwide, and AIMS techniques are increasingly being integrated with standard laboratory operations. This annual review covers applications of AIMS techniques throughout 2021, with a specific focus on AIMS applications in a number of key fields of research including disease diagnostics, forensics and security, food safety testing and environmental sciences. While some new techniques are introduced, the focus in AIMS research is increasingly shifting from the development of novel techniques toward efforts to improve existing AIMS techniques, particularly in terms of reproducibility, quantification and ease-of-use.

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“…Laser diode thermal desorption 21 has also been proposed to desorb samples from surfaces, with the use of a hand-held diode laser as an alternative for eased on-site analysis while maintaining cheap approaches. 22,23 Postionization for laser desorption and MSI helps to ionize the ejected plume of material more efficiently. 20 Different postionization means, such as laser postionization for matrixassisted laser desorption ionization (MALDI-2), 24 ESI postionization (MALDESI, LAESI), 25,26 and photionization, 27 have been proposed.…”

Section: ■ Introductionmentioning

confidence: 99%

Solvent-Assisted Laser Desorption Flexible Microtube Plasma Mass Spectrometry for Direct Analysis of Dried Samples on Paper

Bouza,

Ahlmann,

García-Reyes

et al. 2023

Anal. Chem.

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The present study investigated the potential for solvent-assisted laser desorption coupled with flexible microtube plasma ionization mass spectrometry (SALD-FμTP-MS) as a rapid analytical technique for direct analysis of surface-deposited samples. Paper was used as the demonstrative substrate, and an infrared hand-held laser was employed for sample desorption, aiming to explore cost-effective sampling and analysis methods. SALD-FμTP-MS offers several advantages, particularly for biofluid analysis, including affordability, the ability to analyze low sample volumes (<10 μL), expanded chemical coverage, sample and substrate stability, and in situ analysis and high throughput potential. The optimization process involved exploring the use of viscous solvents with high boiling points as liquid matrices. This approach aimed to enhance desorption and ionization efficiencies. Ethylene glycol (EG) was identified as a suitable solvent, which not only improved sensitivity but also ensured substrate stability during analysis. Furthermore, the addition of cosolvents such as acetonitrile/water (1:1) and ethyl acetate further enhanced sensitivity and reproducibility for a standard solution containing amphetamine, imazalil, and cholesterol. Optimized conditions for reproducible and sensitive analysis were determined as 1000 ms of laser exposure time using a 1 μL solvent mixture of 60% EG and 40% acetonitrile (ACN)/water (1:1). A mixture of 60% EG and 40% ACN/water (1:1) resulted in signal enhancements and relative standard deviations of 12, 20, and 13% for the evaluated standards, respectively. The applicability of SALD-FμTP-MS was further evaluated by successfully analyzing food, water, and biological samples, highlighting the potential of SALD-FμTP-MS analysis, particularly for thermolabile and polarity diverse compounds.

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Hand-Held Diode Laser for On-Site Analysis Using Transportable Mass Spectrometry

Cited by 10 publications

References 31 publications

Blue Laser for Polymerization of Bulk-Fill Composites: Influence on Polymerization Kinetics

Blue Laser for Polymerization of Bulk-Fill Composites: Influence on Polymerization Kinetics

Applications of ambient ionization mass spectrometry in 2021: An annual review

Solvent-Assisted Laser Desorption Flexible Microtube Plasma Mass Spectrometry for Direct Analysis of Dried Samples on Paper

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