Handgrip strength measurement as a predictor of hospitalization costs

Guerra, Rita S.; Amaral, Teresa; Sousa, Ana; Pichel, Fernando; Restivo, Maria Teresa; Ferreira, Sofia; Fonseca, Isabel

doi:10.1038/ejcn.2014.242

Cited by 21 publications

(10 citation statements)

References 42 publications

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“…[ 12 ] Further studies are needed to clarify these results, given the importance of handgrip strength as a reliable parameter of several negative outcomes in the elderly. [ 35 , 36 ]…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial

et al. 2015

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Although older people are particularly liable to sarcopenia, limited research is available on beta-hydroxy-beta-methylbutyrate (HMB) supplementation in this population, particularly in healthy subjects. In this parallel-group, randomized, controlled, open-label trial, we aimed to evaluate whether an oral supplement containing 1.5 g of calcium HMB for 8 weeks could improve physical performance and muscle strength parameters in a group of community-dwelling healthy older women. Eighty healthy women attending a twice-weekly mild fitness program were divided into two equal groups of 40, and 32 of the treated women and 33 control completed the study. We considered a change in the Short Physical Performance Battery (SPPB) score as the primary outcome and changes in the peak torque (PT) isometric and isokinetic strength of the lower limbs, 6-minute walking test (6MWT), handgrip strength and endurance as secondary outcomes. Body composition was assessed with dual-energy X-ray absorptiometry (DXA) and peripheral quantitative computerized tomography (pQCT). The mean difference between the two groups on pre-post change were finally calculated (delta) for each outcome. After 8 weeks, there were no significant differences between the groups’ SPPB, handgrip strength or DXA parameters. The group treated with HMB scored significantly better than the control group for PT isokinetic flexion (delta = 1.56±1.56 Nm; p = 0.03) and extension (delta = 3.32±2.61 Nm; p = 0.03), PT isometric strength (delta = 9.74±3.90 Nm; p = 0.02), 6MWT (delta = 7.67±8.29 m; p = 0.04), handgrip endurance (delta = 21.41±16.28 s; p = 0.02), and muscle density assessed with pQCT. No serious adverse effects were reported in either group. In conclusion, a nutritional supplement containing 1.5 g of calcium HMB for 8 weeks in healthy elderly women had no significant effects on SPPB, but did significantly improve several muscle strength and physical performance parameters.Trial RegistrationClinicalTrials.gov NCT02118181

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“…[ 12 ] Further studies are needed to clarify these results, given the importance of handgrip strength as a reliable parameter of several negative outcomes in the elderly. [ 35 , 36 ]…”

Section: Discussionmentioning

confidence: 99%

Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial

et al. 2015

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“…The Asian Working Group on Sarcopenia has recommended that sarcopenia should be assessed using both skeletal muscle mass and muscle strength, as well as physical function, such as handgrip strength [8]. Previous studies have reported that decreased muscular strength, such as handgrip strength, may be more associated with increased mortality, late-life disability, hospital admissions, cognitive decline, and poor quality of life in older adults [9][10][11][12][13] than skeletal muscle mass. However, current evidence focuses on skeletal muscle mass, with only a few studies demonstrating the association between muscular strength and cardiometabolic health in the US and Taiwan [14,15].…”

Section: Introductionmentioning

confidence: 99%

Associations between Handgrip Strength with Adverse Cardiometabolic Health among Representative Korean Adults

Kim

2019

IJERPH

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Reduced muscle mass and strength are notable features of aging. Loss of muscle mass contributes to cardiometabolic health. Although many studies have focused on skeletal muscle mass, it remains unclear whether muscle strength is beneficial for cardiometabolic health. We aimed to investigate the association between handgrip strength and the risk of adverse cardiometabolic health in middle-aged and older adults in the Korean general population. The study participants included 7602 adults from the Korea National Health and Nutritional Examination Survey (KNHANES). The odds ratio for adverse cardiometabolic health significantly and linearly decreased according to the category of handgrip strength adjusted for potential confounding factors (p-Value < 0.05). In the stratified models by sex we also observed significant associations between handgrip strength and cardiometabolic health in men (p-Value < 0.001), but not in women. Our findings suggest that maintaining higher handgrip strength may contribute to improved cardiometabolic health.

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“…This is advantageous because it is easily and safely assessed in older people (Roberts et al 2011). Previous studies in older people have shown that decreased handgrip strength can predict adverse healthrelated events such as falls, disability, frailty, hospitalization costs, and mortality (Sallinen et al 2010;Xue et al 2011;Chen et al 2012;Guerra et al 2015), and it is commonly used as an objective measure of muscle strength in epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

Jeong

Kim

2018

Tohoku J. Exp. Med.

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Dementia is one of the priority public health problems in the older population, and the number of people with dementia is steadily increasing. The longitudinal association of muscle strength with risk of new-onset cognitive dysfunction in a general population including middle and older adults remains unknown. The purpose of this study was to investigate the effects of low muscle strength on risk for new-onset cognitive dysfunction over 6 years using a large nationwide sample of cognitively healthy adults. Study participants included 6,435 middle and older adults (33,554 person-years of follow-up), using data from the Korean Longitudinal Study of Ageing 2006-2012. Muscular strength was measured using the maximum handgrip strength of each participant as an index of muscle quality. Low muscle strength was defined as one standard deviation below the mean using the handgrip strength index based on the study population. Cognitive function was evaluated using the Mini-Mental Status Evaluation. The hazard ratio (HR) for cognitive dysfunction significantly and linearly increased according to muscle strength status independent of potential confounding factors (HR: 1.36, 95% confidence interval [CI]: 1.18-1.56 for low vs. normal-high group). Using stratified analyses, a significant association between muscle strength status and risk of cognitive impairment was observed in those with low physical activity, but not those with high physical activity. We show that handgrip strength is associated with increased risk of new-onset cognitive dysfunction over 6 years of follow-up in cognitively healthy middle aged and older adults at baseline.

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Handgrip strength measurement as a predictor of hospitalization costs

Cited by 21 publications

References 42 publications

Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial

Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Randomized Controlled Trial

Associations between Handgrip Strength with Adverse Cardiometabolic Health among Representative Korean Adults

Prospective Association of Handgrip Strength with Risk of New-Onset Cognitive Dysfunction in Korean Adults: A 6-Year National Cohort Study

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