Handheld optical coherence tomography angiography

Abstract

Abstract:We developed a handheld optical coherence tomography angiography (OCTA) system using a 100-kHz swept-source laser. The handheld probe weighs 0.4 kg and measures 20.6 × 12.8 × 4.6 cm 3 . The system has dedicated features for handheld operation. The probe is equipped with a mini iris camera for easy alignment. Real-time display of the en face OCT and cross-sectional OCT images in the system allows accurately locating the imaging target. Fast automatic focusing was achieved by an electrically tunable lens controlled by a goldensection search algorithm. An extended axial imaging range of 6 mm allows easy alignment. A registration algorithm using cross-correlation to register adjacent OCT B-frames with propagation from the central frame was used to effectively minimize motion artifacts in volumetric OCTA images captured in relatively short durations of 1 and 2.1 seconds. 2.5 × 2.5 mm (200 × 200 pixels) and 3.5 × 3.5 mm (300 × 300 pixels) retinal angiograms were demonstrated on two awake adult human subjects without the use of any mydriatic eye drops. Opt. Express 4(10), 1890-1908 (2013). 40. I. Grulkowski, J. J. Liu, B. Potsaid, V. Jayaraman, C. D. Lu, J. Jiang, A. E. Cable, J. S. Duker, and J. G.Fujimoto, "Retinal, anterior segment and full eye imaging using ultrahigh speed swept source OCT with verticalcavity surface emitting lasers," Biomed.

Optical coherence tomography angiography as a novel approach to contactless evaluation of sublingual microcirculation: A proof of principle study

“…In this context, a OCTA device has been introduced, which enables imaging in recumbent patients (Flex-Modul for SPECTRALIS ® , Heidelberg Engineering GmbH, Heidelberg, Germany) 25 . In addition, hand-held OCTA devices have been presented 40,41 .…”

Optical coherence tomography in the diagnosis and follow-up of eye diseases in childhood - a review

“…In the last few years angio-OCT technology has gained popularity in the pediatric population and publications associated with amblyopia (16), myopic choroidal neovascular membrane (17) and others could be seen. In 2017 Yang et al developed a prototype of a handheld probe for angio-OCT with good quality of the exported images (18).…”

“…В последните няколко години, с навлизането на ангио-ОСТ технологията в клиничната практика, се появиха публикации при деца, асоциирани със състояния като амблиопия (16), миопична хориоидална неоваскуларна мембрана (17) и др. През 2017 г. Yang и съавтори разработват прототип на портативна сонда за ангио-ОСТ апарат с добро качество на получените образи (18).…”

Development of a clinical prototype of a miniature hand-held optical coherence tomography probe for prematurity and pediatric ophthalmic imaging

“…There are a few research groups who have attempted the development of highperformance hand-held OCT/OCTA probe using high-speed (over 100kHz) swept-source laser for ROP screening. Yang and Campbell et al reported their light weight, 100 kHz Aline-rate handheld probe for OCTA applications and demonstrated high-quality OCTA images in awake adults and anesthetized infants [21,28]. Christian et al reported their 200 kHz A-line-rate handheld OCTA probe designed on an innovative '5F' (focus) optical system, demonstrating OCTA image of foveal area and optical nerve head [29].…”