Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography

Malone, Joseph D.; El‐Haddad, Mohamed T.; Yerramreddy, Suhaas S.; Oguz, Ipek; Tao, Yuankai K.

doi:10.1117/1.nph.6.4.041102

Cited by 30 publications

(49 citation statements)

References 54 publications

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“…The OCT volumes were acquired with 2560 × 500 × 400 × 4 pix. (spectral × lines × frames × repeated frames) [23,6]. OCT-A is performed on motion-corrected [11] OCT volumes using singular value decomposition.…”

Section: Methodsmentioning

confidence: 99%

LIFE: A Generalizable Autodidactic Pipeline for 3D OCT-A Vessel Segmentation

Cui

et al. 2021

Preprint

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Optical coherence tomography (OCT) is a non-invasive imaging technique widely used for ophthalmology. It can be extended to OCT angiography (OCT-A), which reveals the retinal vasculature with improved contrast. Recent deep learning algorithms produced promising vascular segmentation results; however, 3D retinal vessel segmentation remains difficult due to the lack of manually annotated training data. We propose a learning-based method that is only supervised by a self-synthesized modality named local intensity fusion (LIF). LIF is a capillary-enhanced volume computed directly from the input OCT-A. We then construct the local intensity fusion encoder (LIFE) to map a given OCT-A volume and its LIF counterpart to a shared latent space. The latent space of LIFE has the same dimensions as the input data and it contains features common to both modalities. By binarizing this latent space, we obtain a volumetric vessel segmentation. Our method is evaluated in a human fovea OCT-A and three zebrafish OCT-A volumes with manual labels. It yields a Dice score of 0.7736 on human data and 0.8594 ± 0.0275 on zebrafish data, a dramatic improvement over existing unsupervised algorithms.

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Section: Methodsmentioning

confidence: 99%

LIFE: A Generalizable Autodidactic Pipeline for 3D OCT-A Vessel Segmentation

Cui

et al. 2021

Preprint

Self Cite

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“…Demonstrations of (partly) miniaturized OCT systems in research have been accomplished in ophthalmic care using handheld probes, 330,[334][335][336][337][338][339][340][341][342][343] off-the-shelf micro-optical components 52,334,344 or PICs 329,345,346 for dermatologic care using handheld probes, [347][348][349][350][351][352][353] compact packaging of offthe-shelf components, 354 PICs, 353,[355][356][357] and handheld probes for oral 358 and for inner ear [359][360][361][362] imaging. The usage of off-the-shelf microcomponents seems to be the most mature technique for miniaturized OCT at the moment.…”

Section: Oct and Deep Learning Neural Network And Artificial Intelligencementioning

confidence: 99%

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

et al. 2021

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Significance: After three decades, more than 75,000 publications, tens of companies being involved in its commercialization, and a global market perspective of about USD 1.5 billion in 2023, optical coherence tomography (OCT) has become one of the fastest successfully translated imaging techniques with substantial clinical and economic impacts and acceptance.Aim: Our perspective focuses on disruptive forward-looking innovations and key technologies to further boost OCT performance and therefore enable significantly enhanced medical diagnosis.Approach: A comprehensive review of state-of-the-art accomplishments in OCT has been performed. Results:The most disruptive future OCT innovations include imaging resolution and speed (single-beam raster scanning versus parallelization) improvement, new implementations for dual modality or even multimodality systems, and using endogenous or exogenous contrast in these hybrid OCT systems targeting molecular and metabolic imaging. Aside from OCT angiography, no other functional or contrast enhancing OCT extension has accomplished comparable clinical and commercial impacts. Some more recently developed extensions, e.g., optical coherence elastography, dynamic contrast OCT, optoretinography, and artificial intelligence enhanced OCT are also considered with high potential for the future. In addition, OCT miniaturization for portable, compact, handheld, and/or cost-effective capsule-based OCT applications, home-OCT, and self-OCT systems based on micro-optic assemblies or photonic integrated circuits will revolutionize new applications and availability in the near future. Finally, clinical translation of OCT including medical device regulatory challenges will continue to be absolutely essential.Conclusions: With its exquisite non-invasive, micrometer resolution depth sectioning capability, OCT has especially revolutionized ophthalmic diagnosis and hence is the fastest adopted imaging technology in the history of ophthalmology. Nonetheless, OCT has not been completely exploited and has substantial growth potential-in academics as well as in industry. This applies not only to the ophthalmic application field, but also especially to the original motivation of OCT to enable optical biopsy, i.e., the in situ imaging of tissue microstructure with a resolution approaching that of histology but without the need for tissue excision.

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“…For instance, fundus examination with an ophthalmoscope is required after pupil dilation to confirm myopia and determine the stage. Furthermore, handheld spectroscopically coded coherence tomography and reflection (SECTR) systems are commonly used for eye inspection 33 . The handheld probe uses a custom dual-pass scanning lens for full telecentric optical coherence tomography (OCT) scanning.…”

Section: Existing Challenges Of Common Devicesmentioning

confidence: 99%

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

et al. 2021

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Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years. This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology. We first summarize the recent progress in this field by examining the available materials and fabrication techniques, device design principles, mechanisms, and biosafety aspects of micro/nanodevices. Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment, we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions, including oral cancer, eye wrinkles, keratitis, and infections. Along with the identified key challenges, this review concludes with future directions as a small fraction of vast opportunities, calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.

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Handheld spectrally encoded coherence tomography and reflectometry for motion-corrected ophthalmic optical coherence tomography and optical coherence tomography angiography

Cited by 30 publications

References 54 publications

LIFE: A Generalizable Autodidactic Pipeline for 3D OCT-A Vessel Segmentation

LIFE: A Generalizable Autodidactic Pipeline for 3D OCT-A Vessel Segmentation

Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography

Micro/nanodevices for assessment and treatment in stomatology and ophthalmology

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