Hantavirus: General Features and Present Situation in Latin America

Delfraro, Adriana; Raboni, Sônia Mara; Santos, Claudia Nunes Duarte dos

doi:10.1007/978-3-319-54567-7_11

Cited by 4 publications

(5 citation statements)

References 111 publications

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“…As described by several authors, habitat fragmentation due to agricultural activities and human disturbance may contribute to changes in rodent population assemblies, thus infuencing hantavirus seroprevalence (reviewed in 5 6.257022 Environment Dist cost (−) 6 3.880827 * Description of the input variables and units: 1, crops (%); 2, length of rivers (km); 3, wetland (%); 4, maximum average precipitation in 24 h (mm); 5, annual precipitation (mm); 6, distance to coast-continentality (km). Predictor variables included in the seropositive O. favescens favorability environmental model ordered by decreasing relative importance according to Wald test values.…”

Section: Discussionmentioning

confidence: 99%

“…Te current distribution of Oligoryzomys favescens [68] in South America encompasses Argentina, Brazil, Paraguay, and Uruguay territories [69][70][71]. Our previous studies indicate that the yellow pygmy rice rat is the main reservoir host for hantavirus in Uruguay [6,22], and, like other generalist rodents, does not require specifc environmental conditions for survival [70,71]. However, hantavirusinfected yellow pygmy rice rats and the vast majority of HPS cases have been recorded in the southern half of the country, along with the infected Azara's grass mouse reported in this work.…”

Section: Discussionmentioning

confidence: 99%

“…Te frst HPS outbreak in South America was reported in 1995 at El Bolsón, Río Negro province, Argentina, caused by a newly found hantavirus, the Andes virus, carried by the long-tailed pygmy rice rat (Oligoryzomys longicaudatus) [5]. Since then, at least 28 hantavirus lineages have been reported in Central and South America, associated with diferent Sigmodontinae rodents (reviewed in [6]). In 2018, infections with Araraquara (ARAV) hantavirus were described in two bat species; however, the role of these mammals as reservoir hosts deserve a further study [7].…”

Section: Introductionmentioning

confidence: 99%

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Deciphering the Hantavirus Host Range Combining Virology and Species Distribution Models with an Emphasis on the Yellow Pygmy Rice Rat (Oligoryzomys flavescens)

Cabrera

Romero

Guerrero

et al. 2023

Transboundary and Emerging Diseases

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Hantaviruses are the causative agents of hantavirus pulmonary syndrome (HPS) in the Americas. In Central and South America, 28 hantavirus lineages were associated with different Sigmodontinae rodents. Of these, Lechiguanas hantavirus was initially described as a lineage associated with HPS cases in the central region of Argentina. Initial studies on the rodent hosts and viral lineages performed between 1999 and 2005 showed that HPS cases in Uruguay were distributed mostly in the southern region of the country, and that the Lechiguanas hantavirus (LECV) and the closely related Andes Central Plata hantaviruses were the viral lineages most frequently associated with HPS cases, both carried by the yellow pygmy rice rat (Oligoryzomys flavescens). Although these rodents are present all across the Uruguayan territory, determining the extent of the risk areas for hantavirus transmission based on the distribution of the infected rodents may be a useful tool for disease control and prevention. Distribution models are positioned as an effective instrument in the prediction of diseases affecting human health. Assessment of the potential distribution of rodent reservoir hosts and analysis of the influence of environmental factors on hantavirus transmission can help to understand the spatial patterns of disease transmission risk. In the present study, virological studies and species distribution models were integrated to understand the hantavirus infection risk pattern in Uruguay. Virological analyses confirmed that in Uruguay, the primary hantavirus reservoir host for both viral lineages is the yellow pygmy rice rat. Additionally, we report an Azara’s grass mouse (Akodon azarae) infected with the Andes Central Plata viral lineage. Based on the seropositive and nonseropositive yellow pygmy rice rats tested, the distribution models emphasized that favorable environmental conditions for the infected rodents are mainly related to the availability of human-disturbed rural environments with high humidity. We conclude that the innovative application of the methodologies reported herein allowed for the assessment of the current risk territory for HPS in Uruguay.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Deciphering the Hantavirus Host Range Combining Virology and Species Distribution Models with an Emphasis on the Yellow Pygmy Rice Rat (Oligoryzomys flavescens)

Cabrera

Romero

Guerrero

et al. 2023

Transboundary and Emerging Diseases

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“…Within ANDV there are three genotypes: Araraquara orthohantavirus (ARQV), Castelo dos Sonhos orthohantavirus (CASV), and Juquitiba orthohantavirus (JUQV). On the other hand, within LNV there are two genotypes: Anajatuba orthohantavirus (ANJV) and Rio Mamore orthohantavirus (RIOMV) (Colombo et al, 2019; Delfraro et al, 2017; Firth et al, 2012; Oliveira, Guterres, et al, 2014). The ARQV genotype is the most virulent hantavirus in the Brazilian Cerrado and possibly in the world, with lethality of approximately 50% (Figueiredo et al, 2009; Oliveira, Gentile, et al, 2014; Raboni et al, 2009; Travassos da Rosa et al, 2012).…”

Section: Methodsmentioning

confidence: 99%

The influence of sugarcane pre‐harvest fire on hantavirus prevalence in Neotropical small mammals

et al. 2022

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The use of pre-harvest fire in sugarcane fields surprisingly results in an increase in the abundance of Neotropical Sigmodontinae rodents, which might carry hantavirus. By contrast, fire suspension induces a decline in rodents in the first 5 years. The present study aimed to evaluate the effect of sugarcane harvest regimes on hantavirus prevalence in wild rodents. Field collections were carried out on a sugarcane production area in Northeast São Paulo, which is responsible for 30% of the ethanol production in Brazil. A few years after pre-harvest fire suspension, a high prevalence of hantavirus was found in small rodents at lower population density, but apparently higher population growth rate. Differences in life cycle between the rodents and their predators may explain such density patterns, as small rodents can breed twice or even three times each year, whereas their predators usually breed only once a year. Similarly, the temporal dynamics of the predator-prey relationship suggests that hantavirus prevalence is related to small rodent's population growth and not density. Only Akodon montensis, Calomys tener, and Necromys lasiurus contained immunoglobulin G antibodies

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“…It is caused by New World orthohantaviruses (family Hantaviridae , Subfamily Mammantavinirae , Genus Orthohantavirus ; Laenen et al, 2019) which are hosted by rodents of the family Cricetidae. More than 30 Orthohantavirus variants have been described so far in the Americas, most of them in Central and South America (Delfraro et al, 2017; Milholland et al, 2018). Andes orthohantavirus (ANDV) is responsible for most HPS cases in the southern cone of South America, and two variants, ANDV‐ South and ANDV‐ BsAs, are capable of human‐to‐human transmission (Alonso et al, 2020; Ferres et al, 2007; Iglesias et al, 2016; Padula et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

Modelling relative abundance of Oligoryzomys flavescens, an Orthohantavirus reservoir, in an endemic hantavirus pulmonary syndrome zone

Vadell

Fischer

Codesido

et al. 2022

Zoonoses and Public Health

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Hantavirus pulmonary syndrome (HPS) is a zoonotic emerging infectious disease caused by New World orthohantaviruses (family Hantaviridae) hosted by rodents of the family Cricetidae. In Argentina, one of its main hosts is the sigmodontine rodent Oligoryzomys flavescens, a widely distributed mouse of the Pampas, Delta and Espinal ecoregions of central‐east Argentina. Because the abundance of the reservoir and its proportion in the rodent community affects both virus prevalence and human exposure risk, its estimation throughout its known geographical distribution is of key importance for the design of public health strategies to prevent HPS. The aim of this study was therefore to model the relative abundance of O. flavescens in most of the Pampas ecoregion within Buenos Aires Province, Argentina, where hantavirus pulmonary syndrome is endemic. To do this we used owl‐pellet samples collected between 2006 and 2008 from 51 sites distributed throughout most of Buenos Aires province. Mammalian prey in each pellet was identified to the lowest possible taxonomic level by examination of the skulls, dentaries and molars. We modelled the frequency of O. flavescens found in each sample as a function of climatic, environmental, and topographic data of each site. The two best models were applied to a Geo referential Information System to build maps of estimated frequency (as a proxy of relative abundance) within Buenos Aires province. Estimated relative abundance of O. flavescens in Buenos Aires province was significantly associated with annual mean temperature, annual precipitation and presence of freshwater bodies, and varied among sub‐regions, with the Inland and Rolling Pampas being the regions with highest frequencies. Knowing in which areas O. flavescens abundance is expected to be higher can be used to concentrate limited sanitary efforts in those areas that are most needed in order to reduce transmission and increase detection.

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Hantavirus: General Features and Present Situation in Latin America

Cited by 4 publications

References 111 publications

Deciphering the Hantavirus Host Range Combining Virology and Species Distribution Models with an Emphasis on the Yellow Pygmy Rice Rat (Oligoryzomys flavescens)

Deciphering the Hantavirus Host Range Combining Virology and Species Distribution Models with an Emphasis on the Yellow Pygmy Rice Rat (Oligoryzomys flavescens)

The influence of sugarcane pre‐harvest fire on hantavirus prevalence in Neotropical small mammals

Modelling relative abundance of Oligoryzomys flavescens, an Orthohantavirus reservoir, in an endemic hantavirus pulmonary syndrome zone

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