2010
DOI: 10.1007/s10528-010-9407-3
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Haplotypes in the Interleukin 8 Gene and Their Association with Chronic Periodontitis Susceptibility

Abstract: Interleukin-8 (IL-8), which is responsible for the migration and activation of neutrophils, is an important inflammatory mediator involved in the initiation and amplification of acute inflammatory reactions and chronic inflammatory processes. IL-8 plays an important role in periodontitis, an inflammatory disease characterized by the loss of connective tissue and alveolar bone. The aim of this study was to investigate whether the SNPs rs2227307 (+396) and rs2227306 (+781), and the haplotypes they formed togethe… Show more

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Cited by 44 publications
(44 citation statements)
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“…The frequency of the ATC haplotype was 20.3% in cases and 15.6% in controls, demonstrating that individuals with ATC were almost 1.5 times more likely to develop chronic periodontitis than individuals carrying other haplotypes. This result was consistent with that reported by Scarel-Caminaga et al [28]. However, a protective haplotype, AGT, which was almost 1.8 times more prevalent in controls than in cases, displayed a significant positive association with chronic periodontitis in our studies.…”
Section: Discussionsupporting
confidence: 94%
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“…The frequency of the ATC haplotype was 20.3% in cases and 15.6% in controls, demonstrating that individuals with ATC were almost 1.5 times more likely to develop chronic periodontitis than individuals carrying other haplotypes. This result was consistent with that reported by Scarel-Caminaga et al [28]. However, a protective haplotype, AGT, which was almost 1.8 times more prevalent in controls than in cases, displayed a significant positive association with chronic periodontitis in our studies.…”
Section: Discussionsupporting
confidence: 94%
“…Second, population stratification is an unlikely explanation because all of our samples are from the same geographical region. Lastly, similar results were obtained from other genetically independent populations in previous studies [25], [26], [28], [47], reaffirming the observed association.…”
Section: Discussionsupporting
confidence: 90%
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“…When different SNPs are located in close physical proximity to each other on the chromosome and are inherited in blocks without recombination between parental chromosomes, they are called haplotypes [35]. The −1026(A>C)(rs2779249) and +2087(A>G)(2297518) SNPs in the NOS2 gene were previously investigated as haplotypes in Brazilian [26] and Finnish populations [32].…”
Section: Introductionmentioning
confidence: 99%