“…Electrolyte transport across human airway epithelium, followed by water movement is essential for normal mucociliary clearance and allows the maintenance of the aseptic condition of the respiratory tract [4][5]7,14,21,24,41,43]. The function of epithelial cells is to control and regulate ionic composition and the volume of fluids in the airways [2,4,6,21,24,28,33,36,41,[44][45][46]. Therefore, continuous local fluid absorption and secretion following the cephalal ASL motion is necessary to maintain the proper thickness of the fluid lining throughout the entire airway space [2,[6][7]9,14,26,41,43,48].…”