Haptoglobin Function and Regulation in Autoimmune Diseases

Galicia, Georgina; Ceuppens, Jan

doi:10.5772/22483

Cited by 14 publications

(11 citation statements)

References 79 publications

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“…It is also an acute phase protein with antioxidant and immunomodulatory properties. Hp expression was associated with inflammatory autoimmune diseases, including arthritis and SLE, and as a marker of disease activity . Plasma levels of Hp were associated with disease severity in patients with SLE .…”

Section: Discussionmentioning

confidence: 99%

Biomarkers of systemic lupus erythematosus identified using mass spectrometry‐based proteomics: a systematic review

Nicolaou

Kousios

Hadjisavvas

et al. 2016

J Cellular Molecular Medi

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Advances in mass spectrometry technologies have created new opportunities for discovering novel protein biomarkers in systemic lupus erythematosus (SLE). We performed a systematic review of published reports on proteomic biomarkers identified in SLE patients using mass spectrometry‐based proteomics and highlight their potential disease association and clinical utility. Two electronic databases, MEDLINE and EMBASE, were systematically searched up to July 2015. The methodological quality of studies included in the review was performed according to Preferred Reporting Items for Systematic Reviews and Meta‐analyses guidelines. Twenty‐five studies were included in the review, identifying 241 SLE candidate proteomic biomarkers related to various aspects of the disease including disease diagnosis and activity or pinpointing specific organ involvement. Furthermore, 13 of the 25 studies validated their results for a selected number of biomarkers in an independent cohort, resulting in the validation of 28 candidate biomarkers. It is noteworthy that 11 candidate biomarkers were identified in more than one study. A significant number of potential proteomic biomarkers that are related to a number of aspects of SLE have been identified using mass spectrometry proteomic approaches. However, further studies are required to assess the utility of these biomarkers in routine clinical practice.

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Section: Discussionmentioning

confidence: 99%

Biomarkers of systemic lupus erythematosus identified using mass spectrometry‐based proteomics: a systematic review

Nicolaou

Kousios

Hadjisavvas

et al. 2016

J Cellular Molecular Medi

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“…In the present study, the global colon gene expression and RT-PCR validation revealed a tendency of downregulation of Il6, and its downstream factors, Mmp10 and Hp, were reduced significantly by WOL intervention. The expression of Hp has been associated with inflammation is also significantly reduced in inflammatory conditions 64 . The downregulation of proteins related to inflammation and tissue injury (Ceru and Shps1) and the genes Hp, Mmp10, Timp1 in our DSSWOL group suggests that the WOL intervention lowered the extent of inflammation in the colon induced by DSS.…”

Section: Discussionmentioning

confidence: 99%

Integrated omics profiling of dextran sodium sulfate-induced colitic mice supplemented with Wolfberry (Lycium barbarum)

Jia

Lyu

et al. 2020

npj Sci Food

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We used a multi-omics profiling approach to investigate the suppressive effects of 2% Wolfberry (WOL)-enriched diets on dextran sodium sulfate (DSS)-induced colitis in mice. It was observed that in mice fed the WOL diet, the disease activity index, colon shortening, plasma concentrations of matrix metalloproteinase-3 and relative mesenteric fat weight were significantly improved as compared to the DSS group. Results from colon transcriptome and proteome profiles showed that WOL supplementation significantly ameliorated the expression of genes and proteins associated with the integrity of the colonic mucosal wall and colonic inflammation. Based on the hepatic transcriptome, proteome and metabolome data, genes involved in fatty acid metabolism, proteins involved in inflammation and metabolites related to glycolysis were downregulated in WOL mice, leading to lowered inflammation and changes in these molecules may have led to improvement in body weight loss. The integrated nutrigenomic approach thus revealed the molecular mechanisms underlying the ameliorative effect of whole WOL fruit consumption on inflammatory bowel disease.

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“…Previous studies mostly focused on the serum level of Hp expression, which is in contrast to our observation on tissue levels of Hp expression. Since Hp is a secreted acute phase protein that can also be slightly secreted by other organs[ 1 ], except for liver, under inflammation responses, serum Hp expression may gathered from other places instead of originating from the cancer tissues. Furthermore, chronic inflammation in tumor microenvironment reduced the expression level of pro-inflammatory cytokines thereby affecting Hp expression in HCC tumor tissue, since the expressional alteration of Hp expression in hepatocyte in regulated by pro-inflammatory cytokines including IL-6, IL-1β, and TNF-α[ 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Haptoglobin (Hp) is a secreted acute phase protein that is mainly produced in liver[ 1 ]. Elevated levels of Hp in plasma and locally in tumor tissue is closely associated with different clinical conditions, especially in various types of cancers such as ovarian cancer, colorectal cancer, pancreatic cancer, breast, and lung cancer[ 2 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Haptoglobin expression correlates with tumor differentiation and five-year overall survival rate in hepatocellular carcinoma

et al. 2017

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Elevated serum haptoglobin (Hp) is identified as a prognostic marker in multiple types of solid tumors, which is correlated with poor prognosis. HCC is one of the major causes of cancer deaths in worldwide, which remains poor prognosis and is clinically urgent for discovering early diagnostic markers. However, except for serum Hp, the correlation of tumor Hp expression with hepatocellular carcinoma (HCC) progression is still unclear. In this study, we evaluated and identified the tissue Hp expression as a prognostic marker to predict the survival rate of HCC patients. To evaluate the prognostic value of Hp expression for HCC, two cohorts were enrolled in our study, including total 130 matched pair tissue sections (both adjacent non-tumorous and tumor tissue derived from same patient) of HCC patients from Changhua Christian Hospital (CCH) and total 316 RNA-seq data with clinical information of HCC patients from The Cancer Genome Atlas (TCGA) database. In contrast to other types of cancers, HCC tumor tissues have lower Hp protein expression in CCH cohort and have lower Hp mRNA expression in TCGA cohort as compared with adjacent non-tumorous tissues (p < 0.001). Moreover, lower Hp expression is significantly correlated with different stages of HCC cancer differentiation in CCH cohort (one-way ANOVA, p < 0.001). Most importantly, lower Hp expression is highly correlated with poor five-year overall survival rate in TCGA cohort (p < 0.01). Based on our data, we conclude that tissue Hp expression positively correlates with better HCC tumor differentiation and increased five-year overall survival rate of HCC patients. The results indicated that tissue Hp is potentially a prognostic marker for HCC patients. Our findings may further provide a new insight of effective treatments along with biopsy diagnosis of HCC patients.

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Haptoglobin Function and Regulation in Autoimmune Diseases

Cited by 14 publications

References 79 publications

Biomarkers of systemic lupus erythematosus identified using mass spectrometry‐based proteomics: a systematic review

Biomarkers of systemic lupus erythematosus identified using mass spectrometry‐based proteomics: a systematic review

Integrated omics profiling of dextran sodium sulfate-induced colitic mice supplemented with Wolfberry (Lycium barbarum)

Haptoglobin expression correlates with tumor differentiation and five-year overall survival rate in hepatocellular carcinoma

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