Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease

Strandhave, Charlotte; Svensson, My; Krarup, Henrik; Christensen, Jeppe Hagstrup

doi:10.1155/2013/650847

Cited by 7 publications

(4 citation statements)

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“…21 In patients with end-stage renal disease, Hp 2-2 genotype was associated with higher high-sensitive C-reactive protein levels, indicating a relationship between Hp genotype and inflammation. 22 We found no association between Hp 2-2 genotype and overall or death-censored graft loss. Although most of the Hp proteins are synthesized in the liver, where the recipient genotype determines the Hp protein product, there is some production of Hp proteins in the kidney, which for renal recipients will be determined by the donor Hp genotype.…”

Section: Discussioncontrasting

confidence: 57%

Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients

et al. 2017

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Background. Cardiovascular disease is the leading cause of death in renal transplant recipients (RTRs). An association between haptoglobin genotype 2-2 and cardiovascular disease has been found in patients with diabetes mellitus and liver transplant recipients. To date, the role of haptoglobin genotype after renal transplantation has not been studied. Methods.In this single centre retrospective cohort study of 1975 adult Norwegian RTRs, transplanted between 1999 and 2011, we estimated the risk of all-cause and cardiovascular mortality and overall and death censored graft loss for patients with haptoglobin genotype 2-2 compared with genotype 2-1 or 1-1, after adjustment for confounders and competing risks. Results.We found no associations between haptoglobin genotype 2-2 and cardiovascular mortality (subdistributional hazard ratio [SHR] 1.08, 95% confidence interval [CI] 0.78-1.49, p=0.63). We also failed to detect any association between haptoglobin 2-2 genotype and all-cause mortality, overall graft loss and death censored graft loss. Similar results were found in the subpopulation of diabetic RTRs. Conclusion.In this large cohort of kidney transplant recipients, we could not demonstrate any association between haptoglobin 2-2 genotype and patient or graft survival after renal transplantation.

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Section: Discussioncontrasting

confidence: 57%

Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients

et al. 2017

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“…According to MacKellar and Vigerust, people with the Hp2-2 genotype have a much higher risk of being exposed to neurological, infectious and renal pathologies [24], diabetes and also cardiovascular complications such as myocardial infarction and stroke [25]. Hp2-2 has been implicated in the development of diabetes, with a risk of increased inflammation, oxidative stress and atherosclerotic plaque instability [26].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Haptoglobin Gene Polymorphism in cryptogenic Ischemic Stroke in West African Patients

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Cisse,

Barry

et al. 2023

AJBGMB

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Introduction: For a long time, it was assumed that stroke only affected people aged over 60, but recent studies have shown that it can occur in younger people. In the latter group, molecular factors and inter-individual differences in susceptibility are being increasingly incriminated. The aim of our study was therefore to evaluate the haptoglobin gene polymorphism in subjects with cryptogenic ischemic stroke. Methodology: This was a prospective case-control study and included subjects with cryptogenic ischemic stroke followed at the neurology department of FANN hospital in Senegal. Healthy controls were recruited and matched with the cases according to sex and age ±2 years. The Hp gene polymorphism was determined using conventional PCR without enzymatic digestion and biochemical parameters were assayed using the Architect ci4100 system (Abott, USA). Results: Our study included 35 patients with cryptogenic stroke. The mean age of the patients was 45±11 years and the sex ratio was 1:1. Assessment of cardiovascular risk factors showed a high frequency of hypertension (46.57%) followed by dyslipidemia (21.42%) and diabetes (10.71%). Drug use was found in 7.14% of subjects. With regard to haptoglobin genotypes, Hp2-2 was much more prevalent in stroke patients (21.42%) than in control subjects (14.28%). In contrast, the Hp1-1 genotype was more prevalent in control subjects, with a rate of 57.14%, compared with 39.28% for cryptogenic strokes. Conclusion: Our results seem to show that the Hp2-2 genotype is involved in the occurrence of cryptogenic ischemic stroke. However, the impact of these parameters must be assessed in conjunction with other associated cardiovascular risk factors.

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“…However, data are controversial with some studies showing that patients with chronic kidney disease [19] and those with essential hypertension [18] with phenotype Hp 2-2 have significantly higher levels of hsCRP than individuals with phenotypes Hp 1-1 and Hp 2-1. These inconsistencies have been explained based on genetic variations of C-reactive protein (CRP) gene, low levels of physical activity, and gradual increase of CRP with aging [14, 20].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, in our study, hsCRP levels were similar in the different groups included, findings in accordance with previous reports showing that there are no significant statistical differences in the hsCRP levels of apparently healthy individuals [ 17 ], patients with type 2 diabetes [ 14 ], and patients with peripheral occlusive disease [ 18 ], who exhibit phenotype Hp 2-2 compared with individuals exhibiting phenotypes Hp 1-1 and Hp 2-1. However, data are controversial with some studies showing that patients with chronic kidney disease [ 19 ] and those with essential hypertension [ 18 ] with phenotype Hp 2-2 have significantly higher levels of hsCRP than individuals with phenotypes Hp 1-1 and Hp 2-1. These inconsistencies have been explained based on genetic variations of C-reactive protein (CRP) gene, low levels of physical activity, and gradual increase of CRP with aging [ 14 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

et al. 2014

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Objective. To evaluate the association between Haptoglobin (HP) gene polymorphisms with inflammatory status in obese subjects. Materials and Methods. A cross-sectional study was carried out. A total of 276 apparently healthy men and nonpregnant obese women were enrolled and allocated according to the HP genotype into the HP 1/HP 1, HP 2/HP 1, and HP 2/HP 2 groups. Distribution of HP genotypes was 49, 87, and 140 for the HP 1/HP 1, HP 2/HP 1, and HP 2/HP 2, respectively. The HP genotype was determined using the polymerase chain reaction method. A multiple linear regression analysis adjusted by age, sex, waist circumference, and total body fat was used to determine the association between HP genotypes with TNF-α, IL-6, and high-sensitivity C-reactive protein (hsCRP) levels. Results. A multiple linear regression analysis adjusted by sex, waist circumference, and total body fat was performed showing a significant association between the HP 2/HP 2 genotype and TNF-α (β = 0.180; 95% CI 14.41–159.64, P = 0.01) and IL-6 (β = 0.188; 95% CI 1.53–12.72, P = 0.01) levels, but not with hsCRP (β = −0.008; 95% CI −1.64–1.47, P = 0.914) levels, whereas the HP 2/HP 1 genotype showed no association compared with the HP 1/HP 1 genotype (control group). Conclusion. Results of our study show that the HP 2/HP 2 genotype is associated with elevated TNF-α and IL-6, but not with hsCRP, levels in obese subjects.

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Haptoglobin Genotype and Risk Markers of Cardiovascular Disease in Patients with Chronic Kidney Disease

Cited by 7 publications

References 50 publications

Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients

Haptoglobin 2-2 Genotype, Patient, and Graft Survival in Renal Transplant Recipients

Assessment of Haptoglobin Gene Polymorphism in cryptogenic Ischemic Stroke in West African Patients

Haptoglobin 2-2 Genotype Is Associated with TNF-αand IL-6 Levels in Subjects with Obesity

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